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Methoxy‐activated indole‐7‐carbohydrazides; synthesis, antioxidant, and anticancer properties

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dc.contributor.authorKandemir, Hakan
dc.contributor.authorİzgi, Samet
dc.contributor.authorCınar, Irfan
dc.contributor.authorCebeci, Fatma
dc.contributor.authorDirican, Ebubekir
dc.contributor.authorSaglam, Mehmet F.
dc.contributor.authorSengul, Ibrahim F.
dc.date.accessioned2026-01-04T17:12:49Z
dc.date.issued2022-09-07
dc.description.abstractAbstractIndole has been known as a key heterocyclic motif in the development of new structures for both chemical and biological properties. In this current study, a new range of indole‐7‐carbohydrazides has been successfully synthesized starting from the readily available 3‐phenyl and 2,3‐diphenyl 4,6‐dimethoxyindoles. The structures of the novel compounds were confirmed by utilizing1H NMR,13C NMR, FT‐IR, high‐resolution mass spectrometry, and single crystal X‐ ray diffraction techniques. In addition, the indole‐7‐carbohydrazides showed promising antioxidant results in preliminary screens. Some of the new compounds generated from dimethoxy indoles were also screened for their anticancer activity against SH‐SHY5Y (human neuroblastoma), AGS (human gastric adenocarcinoma), and MDA‐MB‐231 (human breast adenocarcinoma) cell lines. The results revealed that the compound12was the promising candidate, showing cytotoxic effects on both neuroblastoma, stomach, and breast cancer cells.
dc.description.urihttps://doi.org/10.1002/jhet.4562
dc.description.urihttps://hdl.handle.net/20.500.12403/3485
dc.description.urihttps://aperta.ulakbim.gov.tr/record/262387
dc.identifier.doi10.1002/jhet.4562
dc.identifier.eissn1943-5193
dc.identifier.endpage85
dc.identifier.issn0022-152X
dc.identifier.openairedoi_dedup___::a6d4b2b316475c7390cd44ce772f287b
dc.identifier.orcid0000-0001-7145-4470
dc.identifier.orcid0000-0001-9260-5223
dc.identifier.orcid0000-0003-4292-6023
dc.identifier.scopus2-s2.0-85137568357
dc.identifier.startpage74
dc.identifier.urihttps://hdl.handle.net/20.500.12597/39972
dc.identifier.volume60
dc.identifier.wos000852569600001
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofJournal of Heterocyclic Chemistry
dc.rightsOPEN
dc.subjectInhibitors
dc.subjectAntiinflammatory Activity
dc.subjectDerivatives
dc.subjectIndole Alkaloids
dc.subject.sdg3. Good health
dc.titleMethoxy‐activated indole‐7‐carbohydrazides; synthesis, antioxidant, and anticancer properties
dc.typeArticle
dspace.entity.typePublication
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