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Does daily fasting shielding kidney on hyperglycemia-related inflammatory cytokine via TNF-α, NLRP3, TGF-β1 and VCAM-1 mRNA expression

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dc.contributor.authorCalik, Ilknur
dc.contributor.authorCinar, Irfan
dc.contributor.authorDincer, Busra
dc.contributor.authorYayla, Muhammed
dc.contributor.authorTavaci, Taha
dc.contributor.authorCadirci, Elif
dc.contributor.authorBilen, Habib
dc.contributor.authorHalici, Zekai
dc.contributor.authorBilen, Arzu
dc.contributor.authorMercantepe, Filiz
dc.date.accessioned2026-01-04T15:54:43Z
dc.date.issued2021-11-01
dc.description.abstractThis study aimed to investigate the effects of blood glucose control and the kidneys' functions, depending on fasting, in the streptozotocin-induced diabetes model in rats via TNF-α, NLRP-3, TGF-β1 and VCAM-1 mRNA expression in the present study. 32 Wistar albino rats were allocated randomly into four main groups; H (Healthy, n = 6), HF (Healthy fasting, n = 6), D (Diabetes, n = 10), DF (Diabetes and fasting, n = 10). Blood glucose and HbA1c levels significantly increased in the D group compared to the healthy ones (p < 0.05). However, the fasting period significantly improved blood glucose and HbA1c levels 14 days after STZ induced diabetes in rats compared to the D group. Similar findings we obtained for serum (BUN-creatinine) and urine samples (creatinine and urea levels). STZ induced high glucose levels significantly up-regulated TNF-α, NLRP-3, TGF-β1 and VCAM-1 mRNA expression and fasting significantly decreased these parameters when compared to diabetic rats. Histopathological staining also demonstrated the protective effects of fasting on diabetic kidney tissue. In conclusion, intermittent fasting regulated blood glucose level as well as decreasing harmful effects of diabetes on kidney tissue. The fasting period significantly decreased the hyperglycemia-related inflammatory cytokine damage on kidneys and also reduced apoptosis in favor of living organisms.
dc.description.urihttps://doi.org/10.1016/j.ijbiomac.2021.08.216
dc.description.urihttps://pubmed.ncbi.nlm.nih.gov/34492249
dc.description.urihttps://dx.doi.org/10.1016/j.ijbiomac.2021.08.216
dc.description.urihttps://avesis.atauni.edu.tr/publication/details/6d0a5270-0e56-487d-832c-4b2e60e5f246/oai
dc.identifier.doi10.1016/j.ijbiomac.2021.08.216
dc.identifier.endpage918
dc.identifier.issn0141-8130
dc.identifier.openairedoi_dedup___::c9732580c1829672752ed378e6d8722c
dc.identifier.orcid0000-0002-3365-7741
dc.identifier.orcid0000-0002-8284-8317
dc.identifier.orcid0000-0003-4150-6262
dc.identifier.orcid0000-0002-4325-1534
dc.identifier.pubmed34492249
dc.identifier.scopus2-s2.0-85114951808
dc.identifier.startpage911
dc.identifier.urihttps://hdl.handle.net/20.500.12597/39146
dc.identifier.volume190
dc.identifier.wos000710167500003
dc.language.isoeng
dc.publisherElsevier BV
dc.relation.ispartofInternational Journal of Biological Macromolecules
dc.rightsCLOSED
dc.subjectBlood Glucose
dc.subjectGlycated Hemoglobin
dc.subjectInflammation
dc.subjectTumor Necrosis Factor-alpha
dc.subjectVascular Cell Adhesion Molecule-1
dc.subjectApoptosis
dc.subjectFasting
dc.subjectKidney
dc.subjectCaspase 9
dc.subjectBlood Urea Nitrogen
dc.subjectDiabetes Mellitus, Experimental
dc.subjectRats
dc.subjectTransforming Growth Factor beta1
dc.subjectCreatinine
dc.subjectHyperglycemia
dc.subjectNLR Family, Pyrin Domain-Containing 3 Protein
dc.subjectAnimals
dc.subjectUrea
dc.subjectRNA, Messenger
dc.subjectRats, Wistar
dc.titleDoes daily fasting shielding kidney on hyperglycemia-related inflammatory cytokine via TNF-α, NLRP3, TGF-β1 and VCAM-1 mRNA expression
dc.typeArticle
dspace.entity.typePublication
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