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Exploring the Molecular Basis of Anticancer Activity in Various Mushroom Species Against Colorectal Cancer Cells

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dc.contributor.authorCeylan, Ipek
dc.contributor.authorOzerkan, Dilsad
dc.contributor.authorEmin, Nuray
dc.contributor.authorAkata, Ilgaz
dc.contributor.authorAltuner, Ergin Murat
dc.date.accessioned2026-01-04T21:07:30Z
dc.date.issued2024-12-01
dc.description.abstractBackground: Mushrooms are shown to protect against the side effects of cancer. Therefore, mushrooms with proven anticancer properties and active ingredients are fascinating in the search for new cancer drugs. Objective: In this study, the effects of extracts from Hericium coralloides (M1), Lactarius deliciosus (M2), Lepista nuda (M3), Pleurotus ostreatus (M4), and Suillus collinitus (M5) together on HCT116 were investigated. Mesenchymal stem cells (MSCs) were used to study the effect on healthy cells. Methods: MTT was used to determine cell viability. Dose-response curves were generated, the IC50 values of the compounds were calculated, and the effect of the extracts was compared using it. The FTIR was used to analyze the quantitative changes of the cellular components. Results and Discussion: The evaluation of the IC50 values of all fungal species showed that they reduced the cell viability of HCT116 cells. In contrast, no significant reduction in cell viability was observed in MSCs. Changes in the ratio of cell membrane lipids, proteins, and cell nucleic acids between control and fungal-treated HCT116 cells were detected by FTIR. Conclusion: Many of the chemotherapeutic agents are of plant origin, and many resources should still be explored to inhibit the side effects of cancer therapy. The data obtained through this experiment will serve as a reference for studies to be a new source of anticancer drugs in modern pharmacology.
dc.description.urihttps://doi.org/10.2174/0115701808324049241108063414
dc.identifier.doi10.2174/0115701808324049241108063414
dc.identifier.endpage4388
dc.identifier.issn1570-1808
dc.identifier.openairedoi_________::fda17be5386e64eaa6b8ed36ebdf74c4
dc.identifier.orcid0000-0002-7738-1214
dc.identifier.orcid0000-0002-0556-3879
dc.identifier.orcid0000-0002-0859-2536
dc.identifier.orcid0000-0002-1731-1302
dc.identifier.orcid0000-0001-5351-8071
dc.identifier.scopus2-s2.0-105004042099
dc.identifier.startpage4378
dc.identifier.urihttps://hdl.handle.net/20.500.12597/42262
dc.identifier.volume21
dc.language.isoeng
dc.publisherElsevier BV
dc.relation.ispartofLetters in Drug Design & Discovery
dc.titleExploring the Molecular Basis of Anticancer Activity in Various Mushroom Species Against Colorectal Cancer Cells
dc.typeArticle
dspace.entity.typePublication
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