Yayın:
Anticancer, antimicrobial, and DNA protection analysis of novel 2,4-dihydroxyquinoline dyes

Basit Görünüm
dc.contributor.authorŞener, Nesrin
dc.contributor.authorMohammed, Hassan Jaballah Abdullah
dc.contributor.authorYerlikaya, Serife
dc.contributor.authorCelik Altunoglu, Yasemin
dc.contributor.authorGür, Mahmut
dc.contributor.authorBaloglu, Mehmet Cengiz
dc.contributor.authorŞener, İzzet
dc.date.accessioned2026-01-04T12:21:26Z
dc.date.issued2018-10-01
dc.description.abstractAbstract A new series of 2,4-dihydroxyquinoline derived disazo dyes has been synthesized by the reaction of 5-amino-4-phenylazo-3-methyl-1H-pyrazole derivatives with 2,4-dihydroxyquinoline. The structures of the obtained dyes were identified by various spectrophotometric methods such as FT-IR, 1H-NMR, and elemental analysis. The synthesized compounds were also examined for different biological activities, including DNA protection, antimicrobial, and anticancer activities. Compound 3b was found most effective on Gram-positive bacteria. A DNA protection assay was applied to all compounds, and it was found that compounds 3h and 3j had a high capacity for binding to DNA. Besides, compounds 3h and 3j showed cytotoxicity against HeLa and PC3 cancer cell lines. These compounds could potentially be used as drugs or drug additives based on their effects on bacterial and cancer cell lines.
dc.description.urihttps://doi.org/10.1016/j.dyepig.2018.04.040
dc.description.urihttps://dx.doi.org/10.1016/j.dyepig.2018.04.040
dc.identifier.doi10.1016/j.dyepig.2018.04.040
dc.identifier.endpage19
dc.identifier.issn0143-7208
dc.identifier.openairedoi_dedup___::b6e40a5ed28adf35ddc54872b7529504
dc.identifier.orcid0000-0001-5370-6048
dc.identifier.orcid0000-0002-2146-9495
dc.identifier.orcid0000-0001-9942-6324
dc.identifier.orcid0000-0003-0540-7523
dc.identifier.scopus2-s2.0-85046089323
dc.identifier.startpage11
dc.identifier.urihttps://hdl.handle.net/20.500.12597/36992
dc.identifier.volume157
dc.identifier.wos000437813700002
dc.language.isoeng
dc.publisherElsevier BV
dc.relation.ispartofDyes and Pigments
dc.rightsCLOSED
dc.subject.sdg3. Good health
dc.titleAnticancer, antimicrobial, and DNA protection analysis of novel 2,4-dihydroxyquinoline dyes
dc.typeArticle
dspace.entity.typePublication
local.api.response{"authors":[{"fullName":"Nesrin Şener","name":"Nesrin","surname":"Şener","rank":1,"pid":{"id":{"scheme":"orcid_pending","value":"0000-0001-5370-6048"},"provenance":null}},{"fullName":"Hassan Jaballah Abdullah Mohammed","name":"Hassan Jaballah Abdullah","surname":"Mohammed","rank":2,"pid":null},{"fullName":"Serife Yerlikaya","name":"Serife","surname":"Yerlikaya","rank":3,"pid":{"id":{"scheme":"orcid","value":"0000-0002-2146-9495"},"provenance":null}},{"fullName":"Yasemin Celik Altunoglu","name":"Yasemin","surname":"Celik Altunoglu","rank":4,"pid":null},{"fullName":"Mahmut Gür","name":"Mahmut","surname":"Gür","rank":5,"pid":{"id":{"scheme":"orcid","value":"0000-0001-9942-6324"},"provenance":null}},{"fullName":"Mehmet Cengiz Baloglu","name":"Mehmet Cengiz","surname":"Baloglu","rank":6,"pid":null},{"fullName":"İzzet Şener","name":"İzzet","surname":"Şener","rank":7,"pid":{"id":{"scheme":"orcid","value":"0000-0003-0540-7523"},"provenance":null}}],"openAccessColor":null,"publiclyFunded":false,"type":"publication","language":{"code":"eng","label":"English"},"countries":null,"subjects":[{"subject":{"scheme":"FOS","value":"0301 basic medicine"},"provenance":null},{"subject":{"scheme":"FOS","value":"0303 health sciences"},"provenance":null},{"subject":{"scheme":"FOS","value":"03 medical and health sciences"},"provenance":null},{"subject":{"scheme":"SDG","value":"3. Good health"},"provenance":null}],"mainTitle":"Anticancer, antimicrobial, and DNA protection analysis of novel 2,4-dihydroxyquinoline dyes","subTitle":null,"descriptions":["Abstract A new series of 2,4-dihydroxyquinoline derived disazo dyes has been synthesized by the reaction of 5-amino-4-phenylazo-3-methyl-1H-pyrazole derivatives with 2,4-dihydroxyquinoline. The structures of the obtained dyes were identified by various spectrophotometric methods such as FT-IR, 1H-NMR, and elemental analysis. The synthesized compounds were also examined for different biological activities, including DNA protection, antimicrobial, and anticancer activities. Compound 3b was found most effective on Gram-positive bacteria. A DNA protection assay was applied to all compounds, and it was found that compounds 3h and 3j had a high capacity for binding to DNA. Besides, compounds 3h and 3j showed cytotoxicity against HeLa and PC3 cancer cell lines. These compounds could potentially be used as drugs or drug additives based on their effects on bacterial and cancer cell lines."],"publicationDate":"2018-10-01","publisher":"Elsevier BV","embargoEndDate":null,"sources":["Crossref"],"formats":null,"contributors":null,"coverages":null,"bestAccessRight":{"code":"c_14cb","label":"CLOSED","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/"},"container":{"name":"Dyes and Pigments","issnPrinted":"0143-7208","issnOnline":null,"issnLinking":null,"ep":"19","iss":null,"sp":"11","vol":"157","edition":null,"conferencePlace":null,"conferenceDate":null},"documentationUrls":null,"codeRepositoryUrl":null,"programmingLanguage":null,"contactPeople":null,"contactGroups":null,"tools":null,"size":null,"version":null,"geoLocations":null,"id":"doi_dedup___::b6e40a5ed28adf35ddc54872b7529504","originalIds":["S0143720818308726","10.1016/j.dyepig.2018.04.040","50|doiboost____|b6e40a5ed28adf35ddc54872b7529504","2802355176"],"pids":[{"scheme":"doi","value":"10.1016/j.dyepig.2018.04.040"}],"dateOfCollection":null,"lastUpdateTimeStamp":null,"indicators":{"citationImpact":{"citationCount":14,"influence":2.8769789e-9,"popularity":9.381129e-9,"impulse":9,"citationClass":"C4","influenceClass":"C5","impulseClass":"C4","popularityClass":"C4"}},"instances":[{"pids":[{"scheme":"doi","value":"10.1016/j.dyepig.2018.04.040"}],"license":"Elsevier TDM","type":"Article","urls":["https://doi.org/10.1016/j.dyepig.2018.04.040"],"publicationDate":"2018-10-01","refereed":"peerReviewed"},{"alternateIdentifiers":[{"scheme":"mag_id","value":"2802355176"},{"scheme":"doi","value":"10.1016/j.dyepig.2018.04.040"}],"type":"Article","urls":["https://dx.doi.org/10.1016/j.dyepig.2018.04.040"],"refereed":"nonPeerReviewed"}],"isGreen":false,"isInDiamondJournal":false}
local.import.sourceOpenAire
local.indexed.atWOS
local.indexed.atScopus

Dosyalar

Koleksiyonlar

Publications