Browsing by Author "Zurnaci M."

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Antiproliferative properties and structural analysis of newly synthesized Schiff bases bearing pyrazole derivatives and molecular docking studies
(2021-10-05) Şener N.; Özkinali S.; Altunoglu Y.C.; Yerlikaya S.; Gökçe H.; Zurnaci M.; Gür M.; Baloglu M.C.; Şener İ.
New pyrazole Schiff bases containing azo groups were synthesized using the condensation reaction between p-nitrobenzaldehyde and (E)-4-(phenyl)-1-H-pyrazole-3,5-diamine in the molar ratio of 1:2. Characterization of the compounds was performed by spectroscopic techniques, including IR, UV-Vis, 1H-NMR and 13C-NMR. Biological activity of the compounds was evaluated by analyzing DNA protection, antimicrobial and anticancer properties. Compound 4 was effective for Salmonella typhimurium with the MIC concentration of 62.5 µg/mL. Moreover, this compound had the highest protection activity on DNA. Cytotoxic activity of compound 4 was determined on the HeLa cancer cell line with the IC50 concentration of 976.6 µM. The anti-cancer characteristic of compounds 4 and 5 for HeLa cancer was theoretically analyzed by molecular docking study as well. Among the tested compounds, compound 4 possessed significant results due to its in vitro cytotoxic properties. Therefore, it may be considered as a potential bioactive agent for cancer treatment studies. In addition, further in vivo analysis can be performed to indicate its anticancer property.
Synthesis of a new 1,3,4-thiadiazole-substituted phenanthroimidazole derivative, its growth on glass/ITO as a thin film and analysis of some surface and optoelectronic properties
(2021-12-28) Zurnaci M.; Ünal F.; Demir S.; Gür M.; Şener N.; Şener İ.
A new phenanthroimidazole derivative (PMItz) bearing a 1,3,4-thiadiazole moiety was prepared and deposited as a thin film on a previously prepared glass/ITO substrate via the physical vapor deposition (PVD) method. The optical and surface morphological properties of the fabricated thin film, glass/ITO/PMItz, were investigated via UV-Vis spectroscopy, atomic force microscopy (AFM) and scanning electron microscopy (SEM). Subsequently, metal/ITO/PMItz/metal (metal: In and Ag) devices were fabricated and their electrical properties were investigated. The optical measurements revealed the reasonably high optical conductivities of the thin films. The energy band gap was calculated to be 2.96 eV, the absorption coefficient was calculated to be 1.3 × 106 m-1 and the optical conductivity was calculated to be 3.14 × 1014. The typical diode characteristics of the devices were demonstrated by electrical measurements. The current-voltage (I-V) measurements revealed that the devices exhibited photo-sensitivity, the photovoltaic effect and strong negative differential resistance (NDR) effect at certain voltage values. The ideality factors in the dark were calculated to be 2.4 and 2.54 for the In/ITO/PMItz/In and Ag/ITO/PMItz/Ag devices, respectively. According to the Hall effect measurements, the conductivity of PMItz was found to be p-type with high carrier mobility and concentration and low specific resistance. This journal is
Synthesis, Characterization, and Theoretical Calculation of New Azo Dyes Derived from [1,5-a]Pyrimidine-5-one Having Solvatochromic Properties
(2019-03-01) Şener N.; Gür M.; Çavuş M.S.; Zurnaci M.; Şener İ.
7-Amino-3-phenylazo-2-methyl-4H-pyrazolo[1,5-a]pyrimidine-5-one (3) was synthesized by the reaction of 5-amino-3-methyl-4-phenylazo-1H-pyrazole and 2-aminobenzothiazole with ethyl cyanoacetate in acetic acid at 150°C. Four novel heterocyclic azo disperse dyes were obtained by the coupling of heterocyclic amines-based diazonium chloride with compound 3. They were purified and characterized by elemental analysis, FTIR, and 1 H NMR. Furthermore, solvatochromic behaviors of related dyes were studied in detail by using ultraviolet–visible absorption spectrometer. The experimental data were supported by density functional theory using b3lyp/cc-pvtz level calculations, and a detailed analysis of predicted tautomeric structures was made.