Browsing by Author "Zeybek, Umit"

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    A Study of Short- and Long-term mRNA Levels of the , and Genes in Obese Mice Induced with High-fat Diet.
    (2018-07-08) Timirci-Kahraman, Ozlem; Yilmaz, Umit; Yilmaz, Nesibe; Cevik, Aydin; Horozoglu, Cem; Celik, Faruk; Gokce, Muhammed Oguz; Ergen, Arzu; Melekoglu, Abdullah; Zeybek, Umit
    Adipocyte gene expression is altered in obese individuals through multiple metabolic and biochemical pathways. In this study, we aimed to examine the expression of resistin (Retn), amylin (Iapp), and dopamine receptor domain 5 (Drd5) genes previously suggested to contribute to the pathogenesis of obesity, albeit controversially. We also aimed to determine the effects on short and long-term mRNA levels of these genes in obese mice, induced with high-fat diet (HFD).
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    Pubmed
    Individual and Combined Effects of CTLA4-CD28 Variants and Oxidant-Antioxidant Status on the Development of Colorectal Cancer.
    (2015-10-01T00:00:00Z) Kucukhuseyin, Ozlem; Turan, Saime; Yanar, Karolin; Arikan, Soykan; Duzkoylu, Yigit; Aydin, Seval; Cakatay, Ufuk; Mezani, Brunilda; Farooqi, Ammad Ahmad; Isitmangil, Gulbu Aydinoğlu; Kiran, Bayram; Cacina, Canan; Yenilmez, Ezgi Nurdan; Ergen, Arzu; Zeybek, Umit; Yaylim, Ilhan
    Colorectal cancer (CRC) is the third most frequent cancer worldwide. Research has revealed the contributions of the immune system and anti-inflammatory pathways in the development of cancer. The balance between cluster of differentiation 28 (CD28) and cytotoxic T-lymphocyte-associated protein 4 (CTLA4) signaling is important for the regulation of immune responses. The oxidant-antioxidant balance by sustaining redox control via several defense mechanisms is also an important factor for the progression of cancer. The aim of the present study was to determine the distribution of CTLA4/CD28 variants and oxidant-antioxidant status in patients with CRC.