Browsing by Author "Yilmaz A."
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Scopus Effect of COVID-19 pandemic on the working of blood transfusion center: A cross-sectional study(2021-06-01) Yilmaz A.; Zerde H.C.; Alay B.; Ergul Z.Aim: Coronavirus disease-2019 (COVID-19) disease which is unknown how much it will affect the work of hospitals, has caused a pandemic all over world. The decrease in donations due to pandemic required regulation of blood supply in hospitals. In our study, we aimed to evaluate the blood center of our hospital during the pandemic period. Methods: Patients’ records of our hospital blood transfusion center were reviewed retrospectively before and during the pandemic. The patients were divided into two groups as pre-pandemic (11 March-30 June 2019) and pandemic period (11 March-30 June 2020). The groups were compared in terms of age range, gender, blood type, blood type of products, diseases causing transfusion, blood/ blood products transfusion/counts, transfusions performed to COVID-19 patients. Results: Four thousand two hundred seventy-one blood product transfusions were performed on 1, 290 patients. Evaluation of diseases that cause transfusion among statistically significant groups in some diseases such as gastrointestinal diseases, genitourinary system diseases, infectious diseases and other diseases was determined. Conclusion: While a decrease in our transfusion rates was observed during the pandemic period, the increase in gastrointestinal system diseases is a striking result. The modern world will encounter these and similar pandemics in the future and we think that each region should evaluate its own blood centers in order to prepare for them.Scopus Ferritin / albumin ratio could be a new indicator of COVID-19 disease mortality(2023-01-01) Taşkin Ö.; Yilmaz A.; Soylu V.G.; Demir U.; Inan F.Ç.Introductions: Despite significant advances in the management of patients with COVID-19, there is a need for markers to guide treatment and predict disease severity. In this study, we aimed to evaluate the relationship of the ferritin/albumin (FAR) ratio with disease mortality. Methodology: Acute Physiology and Chronic Health Assessment II scores and laboratory results of patients diagnosed with severe COVID-19 pneumonia were retrospectively analyzed. The patients were divided into two groups: survivors and non-survivors. Data for ferritin, albumin, and ferritin/albumin ratio among COVID-19 patients were analyzed and compared. Results: The mean age was higher in non-survivors (p = 0.778, p < 0.001, respectively). The ferritin/albumin ratio was significantly higher in the non-survival group (p < 0.05). Taking the cut-off value of the ferritin/albumin ratio of 128.71 in the ROC analysis, it predicted the critical clinical status of COVID-19 with 88.4% sensitivity and 88.4% specificity. Conclusions: ferritin/albumin ratio is a practical, inexpensive, and easily accessible test that can be used routinely. In our study, the ferritin/albumin ratio has been identified as a potential parameter in determining the mortality of critically ill COVID-19 patients treated in intensive care.Scopus Hispidulin exerts a protective effect against oleic acid induced-ARDS in the rat via inhibition of ACE activity and MAPK pathway(2023-01-01) Koc K.; Ozek N.S.; Aysin F.; Demir O.; Yilmaz A.; Yilmaz M.; Geyikoglu F.; Erol H.S.This study investigates the protective role of Hispidulin on acute respiratory distress syndrome (ARDS) in rats. Rats were divided into three groups: control, ARDS, ARDS+ Hispidulin. The ARDS models were established by injecting rats with oleic acid. Hispidulin (100 mg/kg) was injected i.p. an hour before ARDS. Myeloperoxidase (MPO), Interleukin-8 (IL-8), Mitogen-activated protein kinases (MAPK), Lipid Peroxidation (LPO), Superoxide Dismutase (SOD), Glutathione (GSH), and Angiotensin-converting enzyme (ACE) were determined by ELISA. Tumor necrosis factor-alpha (TNF-α) expression was described by RT-qPCR. Caspase-3 immunostaining was performed to evaluate apoptosis. Compared with the model group, a significant decrease was observed in the MPO, IL-8, MAPK, ACE, LPO levels, and TNF-α expression in the ARDS+ Hispidulin group. Moreover, reduced caspase-3 immunoreactivity and activity of ACE were detected in the Hispidulin+ARDS group. The protective effect of Hispidulin treatment may act through inhibition of the ACE activity and then regulation of inflammatory cytokine level and alteration of apoptosis.Scopus ‘Moving the Kaleidoscope’ to see the effect of creative personality traits on creative thinking dispositions of preservice teachers: The mediating effect of creative learning environments and teachers’ creativity fostering behavior(2021-09-01) Ayyildiz P.; Yilmaz A.This study aimed to examine the effect of creative personality traits on creative thinking dispositions through creative learning environments and teacher behaviors that foster creativity. Gender, department, and grade level are also defined as common variables. 1320 teacher candidates who were selected with purposeful and appropriate sampling supported the research. 726 of these individuals are females and 594 are males. Participants in the study are teacher candidates from education faculties, science, mathematics, classroom, and educational sciences departments. Whilst determining the participants, attention was paid to the selection of those who have previously taken courses that are directly or indirectly related to creative thinking, critical and analytical thinking, entrepreunership and creativity. Descriptive and inferential statistics were used in the analysis of the research data. Aside from this, the mediation effect of variables was performed using Hayes' number 6 serial multiple mediation analysis models. As a result of the research, it was found that creative personality traits positively predicted creative thinking dispositions through the learning environment and teachers' fostering behaviors. The creative learning environment and teachers' fostering behaviors similarly have a positive mediating effect.Scopus Study of bacteria isolated from COVID-19 and non-COVID-19 intensive care units and determination of their antibiotic susceptibility profiles(2022-10-01) Kilinç Ç.; Çöplü N.; Yaşar Duman M.; Çalişir B.; Tüfekci E.F.; Gülhan M.; Yilmaz A.; Soylu V.G.Nosocomial infections occur 48-72 hours after hospitalization, especially caused by bacteria, and pose a high risk for patients in intensive care units (ICUs), including COVID-ICUs. This study aimed to reveal bacteria distribution and antibiotic susceptibility profiles isolated from various clinical samples of non-COVID-ICU and COVID-ICU patients. We included in this study bacterial strains isolated from ICUs patients in Kastamonu Training and Research Hospital between March 2020 and October 2020. We identified the strains using the Vitek 2 compact automated system (BioMerieux, France) and standard microbiological methods. Using the Vitek 2 automated system, we analyzed antibiotic susceptibility tests and interpreted the results based on the European Committee for Antimicrobial Susceptibility Tests (EUCAST) guideline. There were 302 patients in the non-COVID-ICUs and 440 patients in the COVID-ICUs. We isolated a total of 470 strains, 370 from non-COVID-ICUs and 100 from COVID-ICUs. Acinetobacter spp. was the most frequently isolated strains for both ICUs. Acinetobacter spp. isolated from non-COVID-ICUs had higher resistance rates to meropenem (p= 0.043), ceftazidime (p= 0.014), and levofloxacin (p<0.001) antibiotics than strains from COVID-ICUs. Antibiotic susceptibility profiles of other strains were similar for both ICUs. As a result, the incidence of nosocomial infections in COVID-ICU patients was lower than in non-COVID-ICU patients. Health personnel working in COVID-ICUs may have played an important role in this, as they were more careful about using personal protective equipment and complying with hygiene rules. However, antibiotic resistance continues to be a serious problem in ICUs, including COVID-ICUs.