Browsing by Author "Yigin, A"

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    Web of Science
    Expression of ADAMTS-7 in myocardial dystrophy associated with white muscle disease in lambs
    (2018.01.01) Yumusak, N; Yigin, A; Polat, PF; Hitit, M; Yilmaz, R
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    Pubmed
    Expression of ADAMTS-7 in myocardial dystrophy associated with white muscle disease in lambs.
    (2018-03-01T00:00:00Z) Yumusak, N; Yigin, A; Polat, P F; Hitit, M; Yilmaz, R
    The aim of the present study was to investigate the role of ADAMTS-7 gene in the pathogenesis of myocardial dystrophy associated with white muscle disease (WMD) in lambs. A total of 217 cardiac tissue samples from lambs with WMD were used in the study. Histopathological sections of the samples were stained with hematoxylin-eosin (HE) and examined using Western-blot, real-time PCR (RT-PCR) and immunohistochemistry for ADAMTS-7 gene expression, and the findings were statistically evaluated. Histopathological examinations revealed fibrosis associated with hyalinization, necrosis and granular calcifications in cardiomyocytes. Western blot and RT-PCR showed a statistically significant upregulation of ADAMTS-7 (p<0.05) (p<0.05). Immunohistochemical analyses showed that immunopositive cell numbers significantly high for ADAMTS-7 (p<0.05). The study has revealed that ADAMTS-7 gene is significantly expressed in myocardial dystrophy associated with WMD in addition to its role in the pathogenesis of this disease.