Browsing by Author "Simsek, Ozcan"

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    Pubmed
    Biochemical, Antioxidant Properties and Antimicrobial Activity of Epiphytic Leafy Liverwort (L.) Dumort.
    (2023-05-04T00:00:00Z) Simsek, Ozcan; Canli, Kerem; Benek, Atakan; Turu, Dilay; Altuner, Ergin Murat
    In this study, the biochemical, antioxidant properties, and antimicrobial activity of the epiphytic leafy liverwort (L.) Dumort were investigated. Due to the scarcity and difficulty in obtaining liverworts, research on their bioactivity is limited; thus, this study aimed to uncover the potential of . The antimicrobial activity was evaluated against various microorganisms, including food isolates, clinical isolates, multidrug-resistant strains, and standard strains, using the disk diffusion method and determining the minimum inhibitory concentration (MIC) values. This study represents the first antioxidant investigation on and an antimicrobial study using ethanol extract and the disk diffusion method. Notably, susceptibility was observed in ATCC 29212, FI, ATCC 7644, MDR, and ATCC 25923. The antioxidant capacity was assessed using the DPPH method, emphasizing the high scavenging performance. Gas chromatography-mass spectrometry (GC-MS) analysis identified the primary compounds as frullanolide (19.08%), 2,3-Dimethylanisole (15.21%), linoleic acid (11.11%), palmitic acid (9.83%), and valerenic acid (5.3%). The results demonstrated the significant antimicrobial activity of against the tested microorganisms and its potent antioxidant properties. These findings emphasize the potential of as a promising source of natural antimicrobial and antioxidant agents, underscoring the importance of further investigation into its bioactive compounds and elucidating the mechanisms of action in future studies.
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    Pubmed
    Biochemical, Antioxidant Properties and Antimicrobial Activity of Steno-Endemic .
    (2023-08-02) Canli, Kerem; Bozyel, Mustafa Eray; Turu, Dilay; Benek, Atakan; Simsek, Ozcan; Altuner, Ergin Murat
    (Lamiaceae) is an Eastern Mediterranean plant that is widely used in Turkish traditional medicine. This study aimed to investigate the biochemical composition, antimicrobial activity, and antioxidant potential of . In this study, the biochemical composition of the ethanol extract (OOEt) was analyzed using GC-MS. The antimicrobial activity was investigated using a disk diffusion test and determining minimum inhibitory concentrations (MIC) against 30 microorganism strains, including 28 bacteria (some multidrug-resistant) and 2 fungi. Additionally, the antioxidant activity was evaluated using the DPPH method. The main component identified was carvacrol. OOEt demonstrated antimicrobial activity against a wide range of tested microorganism strains. OOEt displayed the highest activity against (a Gram-positive bacterium) at 100 µL with a 52 mm inhibition zone. Additionally, DSMZ 50071 and P1, which are Gram-negative bacteria, were the most sensitive strains with a 24 mm inhibition zone in 100 µL of OOEt. The data obtained from (a multidrug-resistant strain) is particularly striking, as higher activity was observed compared to all positive controls. All tested fungal strains showed more effective results than positive controls. The antioxidant activity of OOEt was found to be stronger than that of the positive control, ascorbic acid. This study determined that has significant antimicrobial and antioxidant potential.