Browsing by Author "Ramadan M.A.G., Baloglu M.C., Altunoglu Y.C., Kandemirli F., Burhan H., Aygün A., Sayiner H.S., Ozyigit F., Şen F."
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Publication Evaluation of biological activity of 5-fluoro-isatin thiosemicarbazone derivatives(2020-06-01) Ramadan M.A.G., Baloglu M.C., Altunoglu Y.C., Kandemirli F., Burhan H., Aygün A., Sayiner H.S., Ozyigit F., Şen F.; Ganim, MA, Baloglu, MC, Altunoglu, YC, Kandemirli, F, Burhan, H, Aygun, A, Sayiner, HS, Ozyigit, F, Sen, FIsatin based materials can exhibit a wide range of biological activities including antimicrobial, antiviral, antifungal, anthelmintic, antitumor, anti-HIV, anti-inflammatory, antidepressant, antioxidant, anticonvulsant, antitubercular, analgesic, and central nervous system depressant activities. In this study, four compounds containing 5-Fluoro-isatin thiosemicarbazone with methoxyphenyl or methoxyphenyl in different positions and zinc complexes were evaluated based on their biological activities. Compound 2 was the strongest compound affecting gramnegative bacteria compared to the other compounds. Also, this compound indicated better antimicrobial activity than positive control antibiotics. Besides, compound 3 was the only compound that inhibited the growth of Salmonella spp. such as Salmonella enteritidis ATCC 13076 and Salmonella typhimurium NRRLE 4463. 5-Fluoro-Isatin thiosemicarbazone and its derivatives also showed DNA protection property from moderate to good protections. Among them, compound 4 displayed the highest DNA binding affinity. These compounds possessed a capacity for utilization as drugs or drug additives based on their effects on bacteria strains and DNA binding affinity.