Browsing by Author "Ozdemir R.C."

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Effect of Ginseng root (Araliaceae sp.) extracts on sperm quality parameters and reproductive performance in rainbow trout (oncorhynchus mykiss)
(2019-01-01) Sonmez A.Y.; Ozdemir R.C.; Bilen S.; Kadak A.E.
In this study, ginseng root extract was manufactured and used as a food additive for 8 to 9-month old male rainbow trout (Oncorhynchus mykiss). The extracts were added to the food in two different ratios, 1 g/kg and 2 g/kg. The control group was given a commercial feed with no additive. The fish ate the provided feed for 120 days ad libitum. Sperm samples were taken from fish every 30 days. We observed that the gonadosomatic index (GSI) in the experimental groups was higher than in the control group. Motility duration of groups 1 and 2 was 10 seconds more than the control group. Sperm density averages (SDA) were 7.74±0.61x109, 8.62±0.53 x109 and 11.27±0.78x109, respectively. All sperm samples taken from each experimental group were used for fertilization. Fertilization ratios of control and experimental groups were 65±10%, 84.9±5% and 90±6%, respectively. The hatching ratio was also very high in the extract added groups compared to the control group.
Pharmacokinetics and pharmacokinetic/pharmacodynamic integration of enrofloxacin following single oral administration of different doses in brown trout (Salmo trutta)
(2021-11-01) Uney K.; Terzi E.; Corum D.D.; Ozdemir R.C.; Bilen S.; Corum O.
The pharmacokinetic of enrofloxacin was investigated in brown trout (Salmo trutta) following oral administration of 10, 20, and 40 mg/kg doses at 11 ± 1.5 °C. Furthermore, MICs of en-rofloxacin against Aeromonas hydrophila and A. sobria were determined. The plasma concentrations of enrofloxacin and ciprofloxacin were determined using HPLC–UV and analyzed by non‐compart-mental method. Following oral administration at dose of 10 mg/kg, total clearance (CL/F), area under the concentration–time curve (AUC0−∞) and peak plasma concentrations (Cmax) were 41.32 mL/h/kg, 242.02 h*μg/mL and 4.63 μg/mL, respectively. When compared to 10 mg/kg dose, the dose‐normalized AUC0–∞ and Cmax were increased by 56.30% and 30.08%, respectively, while CL/F decreased by 38.4% at 40 mg/kg dose, suggesting the non‐linearity. Ciprofloxacin was not detected in the all of plasma samples. The MIC values of enrofloxacin were ranged 0.0625–4 μg/mL for A. hydrophila and 0.0625–2 μg/mL for A. sobria. The oral administration of enrofloxacin at 10 (for 192 h) and 20 (for 240 h) mg/kg doses provided the AUC of enrofloxacin equal to 1.23 and 1.96‐fold MICs, respectively, for A. hydrophila and A. sobria with the MIC90 values of 1 μg/mL. However, further researches are needed on the PK/PD study of enrofloxacin for the successful treatment of infections caused by A. hydrophila and A. sobria in brown trout.