Browsing by Author "Muğlu H., Yakan H., Shouaib H."

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    New 1,3,4-thiadiazoles based on thiophene-2-carboxylic acid: Synthesis, characterization, and antimicrobial activities
    (2020-03-05) Muğlu H., Yakan H., Shouaib H.; Muglu, H, Yakan, H, Shouaib, HA
    Novel 1,3,4-thiadiazole derivatives were prepared by cyclization reaction of thiophene-2-carboxylic acid with N-arylthiosemicarbazides and POCl3. The antibacterial activities of the synthesized compounds were tested against Gram-negative bacteria (Salmonella enteritidis, Salmonella typhimurium, Enterobacter aerogenes, Salmonella infantis, Salmonella kentucky, and Escherichia coli), Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis, and Enterococcus durans), and the fungus Candida albicans using the disk diffusion method. Selected 1,3,4-thiadiazole derivatives exhibited effective antimicrobial activity against S. aureus, C. albicans, S. typhimurium, E. aerogenes, and S. kentucky. Therefore, 1,3,4-thiadiazole derivatives can be considered as bioactive agents for pharmacological and medicinal applications. The synthesized compounds were characterized by using IR, 1H NMR, and 13C NMR spectroscopies and elemental analysis.