Browsing by Author "Metin, H."

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Effects of Bacterioruberin-Rich Haloarchaeal Carotenoid Extract on the Thermal and Oxidative Stabilities of Fish Oil
(Multidisciplinary Digital Publishing Institute (MDPI), 2023) Kesbiç, F.I.; Metin, H.; Fazio, F.; Parrino, V.; Kesbiç, O.S.
This study aimed to assess the efficacy of a bacterioruberin-rich carotenoid extract (HAE) derived from the halophilic archaea Halorubrum ezzemoulense DSM 19316 in protecting crude fish oil against thermal oxidation. The research used fish oil derived from anchovies, which had a peroxide value (PV) of 6.44 ± 0.81 meq O2 kg−1. To assess the impact of HAE on the thermal stability and post-oxidation characteristics of fish oil, several concentrations of HAE were added to the fish oil samples: 0 ppm (no additive) (HAE0), 50 ppm (HAE50), 100 ppm (HAE100), 500 ppm (HAE500), and 1000 ppm (HAE1000). Furthermore, a control group was established with the addition of 100 ppm butylated hydroxytoluene (BHT100) in order to evaluate the effectiveness of HAE with a synthetic antioxidant that is commercially available. Prior to the fast oxidation experiment, thermogravimetric analysis was conducted on samples from all experimental groups. At the conclusion of the examination, it was seen that the HAE500 and HAE1000 groups exhibited a delay in the degradation temperature. The experimental groups underwent oxidation at a temperature of 55.0 ± 0.5 °C for a duration of 96 h. The measurement of PV was conducted every 24 h during this time. PV in all experimental groups exhibited a time-dependent rise (p < 0.05). However, the HAE500 group had the lowest PV measurement at the conclusion of the 96 h period (p < 0.05). Significant disparities were detected in the fatty acid compositions of the experimental groups at the completion of the oxidation experiment. The HAE500 group exhibited the highest levels of EPA, DHA, and ΣPUFA at the end of oxidation, with statistical significance (p < 0.05). Through the examination of volatile component analysis, specifically an oxidation marker, it was shown that the HAE500 group exhibited the lowest level of volatile components (p < 0.05). Consequently, it was concluded that the addition of HAE to fish oil provided superior protection compared to BHT at an equivalent rate. Moreover, the group that used 500 ppm HAE demonstrated the highest level of performance in the investigation.
Effects of Bacterioruberin-Rich Haloarchaeal Carotenoid Extract on the Thermal and Oxidative Stabilities of Fish Oil
(2023) Kesbiç, F.I.; Metin, H.; Fazio, F.; Parrino, V.; Kesbiç, O.S.
This study aimed to assess the efficacy of a bacterioruberin-rich carotenoid extract (HAE) derived from the halophilic archaea DSM 19316 in protecting crude fish oil against thermal oxidation. The research used fish oil derived from anchovies, which had a peroxide value (PV) of 6.44 ± 0.81 meq O kg. To assess the impact of HAE on the thermal stability and post-oxidation characteristics of fish oil, several concentrations of HAE were added to the fish oil samples: 0 ppm (no additive) (HAE0), 50 ppm (HAE50), 100 ppm (HAE100), 500 ppm (HAE500), and 1000 ppm (HAE1000). Furthermore, a control group was established with the addition of 100 ppm butylated hydroxytoluene (BHT100) in order to evaluate the effectiveness of HAE with a synthetic antioxidant that is commercially available. Prior to the fast oxidation experiment, thermogravimetric analysis was conducted on samples from all experimental groups. At the conclusion of the examination, it was seen that the HAE500 and HAE1000 groups exhibited a delay in the degradation temperature. The experimental groups underwent oxidation at a temperature of 55.0 ± 0.5 °C for a duration of 96 h. The measurement of PV was conducted every 24 h during this time. PV in all experimental groups exhibited a time-dependent rise ( < 0.05). However, the HAE500 group had the lowest PV measurement at the conclusion of the 96 h period ( < 0.05). Significant disparities were detected in the fatty acid compositions of the experimental groups at the completion of the oxidation experiment. The HAE500 group exhibited the highest levels of EPA, DHA, and ΣPUFA at the end of oxidation, with statistical significance ( < 0.05). Through the examination of volatile component analysis, specifically an oxidation marker, it was shown that the HAE500 group exhibited the lowest level of volatile components ( < 0.05). Consequently, it was concluded that the addition of HAE to fish oil provided superior protection compared to BHT at an equivalent rate. Moreover, the group that used 500 ppm HAE demonstrated the highest level of performance in the investigation.
Effects of Bacterioruberin-Rich Haloarchaeal Carotenoid Extract on the Thermal and Oxidative Stabilities of Fish Oil
(2023.01.01) Kesbiç, F.I.; Metin, H.; Fazio, F.; Parrino, V.; Kesbiç, O.S.
This study aimed to assess the efficacy of a bacterioruberin-rich carotenoid extract (HAE) derived from the halophilic archaea Halorubrum ezzemoulense DSM 19316 in protecting crude fish oil against thermal oxidation. The research used fish oil derived from anchovies, which had a peroxide value (PV) of 6.44 +/- 0.81 meq O-2 kg(-1). To assess the impact of HAE on the thermal stability and post-oxidation characteristics of fish oil, several concentrations of HAE were added to the fish oil samples: 0 ppm (no additive) (HAE0), 50 ppm (HAE50), 100 ppm (HAE100), 500 ppm (HAE500), and 1000 ppm (HAE1000). Furthermore, a control group was established with the addition of 100 ppm butylated hydroxytoluene (BHT100) in order to evaluate the effectiveness of HAE with a synthetic antioxidant that is commercially available. Prior to the fast oxidation experiment, thermogravimetric analysis was conducted on samples from all experimental groups. At the conclusion of the examination, it was seen that the HAE500 and HAE1000 groups exhibited a delay in the degradation temperature. The experimental groups underwent oxidation at a temperature of 55.0 +/- 0.5 degrees C for a duration of 96 h. The measurement of PV was conducted every 24 h during this time. PV in all experimental groups exhibited a time-dependent rise (p < 0.05). However, the HAE500 group had the lowest PV measurement at the conclusion of the 96 h period (p < 0.05). Significant disparities were detected in the fatty acid compositions of the experimental groups at the completion of the oxidation experiment. The HAE500 group exhibited the highest levels of EPA, DHA, and Sigma PUFA at the end of oxidation, with statistical significance (p < 0.05). Through the examination of volatile component analysis, specifically an oxidation marker, it was shown that the HAE500 group exhibited the lowest level of volatile components (p < 0.05). Consequently, it was concluded that the addition of HAE to fish oil provided superior protection compared to BHT at an equivalent rate. Moreover, the group that used 500 ppm HAE demonstrated the highest level of performance in the investigation.
Evaluation of Patients with COVID-19 Followed Up in Intensive Care Units in the Second Year of the Pandemic: A Multicenter Point Prevalence Study
(2024.01.01) Güngör, S.; Ediboglu, Ö.; Moçin, Ö.Y.; Adigüzel, N.; Tunçay, E.; Iscanli, I.G.E.; Er, B.; Karakurt, Z.; Turan, S.; Kosovali, B.D.; Mutlu, N.M.; Kayar, D.; Bektas, S.G.; Uysal, E.; Segmen, F.; Alp, G.; Erdem, D.; Selmi, N.H.; Güven, P.; Özçelik, Z.; Ocakcioglu, M.; Özgür, C.Y.; Yilmaz, R.; Özel, D.B.; Cebeci, H.; Güler, B.; Cansever, C.; Cakirca, M.; Inceöz, H.; Solmaz, I.; Sipahioglu, F.Ö.; Aydin, E.M.; Dayanir, H.; Öner, S.F.; Karatepe, U.; Özen, S.; Boran, M.; Ergül, D.F.; Kasapoglu, U.S.; Delen, L.A.; Toy, E.; Altun, K.; Albayrak, T.; Yanal, H.; Zaim, G.; Yarar, V.; Kilinç, G.; Deniz, M.; Özdemir, E.; Soylu, V.G.; Yilmaz, A.; Saygili, S.M.; Öztürk, E.K.; Ergan, B.; Eyüpoglu, S.; Sahin, Y.; Yüksel, B.; Bulut, A.; Saritas, A.; Yeniay, H.; Genç, M.; Kargin, F.; Özcan, O.; Karakoç, E.; Karaca, U.; Sözütek, D.; Sari, S.; Senoglu, N.; Aygün, H.; Yigit, A.C.; Kavruk, N.; Uzan, C.A.; Biçakcioglu, M.; Solak, S.; Özçelik, H.K.; Uluç, K.; Yildirim, I.; Arar, M.C.; Demirel, I.; Küver, S.U.; Özgür, E.S.; Aydin, K.; Dönmez, G.E.; Aygencel, G.; Esmaoglu, A.; Aydin, B.S.; Tokur, M.E.; Ekren, P.K.; Aydemir, Y.; Güney, B.Ç.; Erdil, Ö.Y.; Tünay, A.; Bahadir, T.; Uçkun, S.; Kocaoglu, N.; Pinar, H.U.; Karaca, N.K.; Gültekin, H.; Ayvat, P.; Özer, A.B.; Eroglu, A.; Kuyrukluyildiz, U.; Baytar, Ç.; Ayoglu, H.; Mizrakçi, S.; Metin, H.; Mutlu, O.P.Z.; Yilmaz, H.; Tüzüner, F.
OBJECTIVE: A 1 -day point prevalence study was planned to obtain country data by determining the clinical characteristics, follow-up and treatment methods of coronavirus disease 2019 (COVID-19) cases that required intensive care unit (ICU) treatment in the second year of the pandemic. MATERIAL AND METHODS: All patients who were hospitalized in the ICUs due to COVID-19 between March 11, 2022, 08.00 AM, and March 12, 2022, 08.00 AM, were included in the study. Demographic characteristics, intensive care and laboratory data, radiological characteristics, and follow-up results of the patients were recorded. RESULTS: A total of 811 patients from 59 centers were included in the study, 59% of the cases were male, and the mean age was 74 +/- 14 years. At least one comorbid disease was present in 94% of the cases, and hypertension was the most common. When ICU weight scores were examined, Acute Physiology and Chronic Health Evaluation -II: 19 (15-27) and Sequential Organ Failure Assessment: 7 (4-10) were seen. Sepsis was present in 37% (n = 298) of cases. PaO2/FiO2 ratios of the patients were 190 the highest and 150 the lowest and 51% of the cases were followed via invasive mechanical ventilation. On the study day, 73% bilateral involvement was seen on chest x-ray, and ground -glass opacities (52%) were the most common on chest tomography. There was growth in culture in 40% (n = 318) of the cases, and the most common growth was in the tracheal aspirate (42%). CONCLUSION: The clinical course of COVID-19 is variable, and ICU follow-up was required due to advanced age, comorbidity, presence of respiratory symptoms, and widespread radiological involvement. The need for respiratory support and the presence of secondary infection are important issues to be considered in the follow-up. Despite the end of the second year of the pandemic and vaccination, the high severity of the disease as well as the need for follow-up in ICUs has shown that COVID-19 is an important health problem.
Evaluation of Patients with COVID-19 Followed Up in Intensive Care Units in the Second Year of the Pandemic: A Multicenter Point Prevalence Study
(AVES, 2024) Güngör, S.; Ediboğlu, Ö.; Moçin, Ö.Y.; Adıgüzel, N.; Tunçay, E.; İşcanlı, İ.G.E.; Er, B.; Karakurt, Z.; Turan, S.; Kosavalı, B.H.; Mutlu, N.M.; Kayar, D.; Bektaş, Ş.G.; Uysal, E.; Seğmen, F.; Gürayalp, A.; Erdem, D.; Selmi, N.H.; Güven, P.; Özçelik, Z.; Ocakcıoğlu, M.; Özgür, C.Y.; Yılmaz, R.; Özel, D.B.; Cebeci, H.; Güler, B.; Cansever, C.; Çakırca, M.; İnceöz, H.; Solmaz, İ.; Sipahioğlu, F.H.; Aydın, E.M.; Dayanır, H.; Öner, S.F.; Karatepe, U.; Özen, S.; Boran, M.; Ergül, D.F.; Kasapoğlu, U.S.; Delen, L.A.; Toy, E.; Altun, K.; Albayrak, T.; Yanal, H.; Zaim, G.; Yarar, V.; Kılınç, G.; Deniz, M.; Özdemir, E.; Soylu, V.G.; Yılmaz, A.; Saygılı, S.B.; Öztürk, E.K.; Ergan, B.; Eyüpoğlu, S.; Şahin, Y.; Yüksel, B.; Bulut, A.; Sarıtaş, A.; Yeniay, H.; Genç, M.; Kargın, F.; Özcan, O.; Karakoç, E.; Karaca, Ü.; Sözütek, D.; Sarı, S.; Şenoğlu, N.; Aygün, H.; Yiğit, A.C.; Kavruk, N.; Uzan, Ç.A.; Bıçakçıoğlu, M.; Solak, S.; Özçelik, H.K.; Uluç, K.; Yıldırım, İ.; Arar, M.C.; Demirel, İ.; Küver, S.U.; Özgür, E.S.; Aydın, K.; Dönmez, G.E.; Aygencel, G.; Esmaoğlu, A.; Aydın, B.S.; Tokur, M.E.; Ekren, P.K.; Aydemir, Y.; Güney, B.Ç.; Erdil, Ö.Y.; Tünay, A.; Bahadır, T.; Uçkun, S.; Kocaoğlu, N.; Pınar, H.U.; Karaca, N.K.; Gültekin, H.; Ayvat, P.; Özer, A.B.; Eroğlu, A.; Kuyrukluyıldız, U.; Baytar, Ç.; Ayoğlu, H.; Mızrakçı, S.; Metin, H.; Mutlu, Ö.P.Z.; Yılmaz, H.; Tüzüner, F.
OBJECTIVE: A 1-day point prevalence study was planned to obtain country data by determining the clinical characteristics, follow-up and treatment methods of coronavirus disease 2019 (COVID-19) cases that required intensive care unit (ICU) treatment in the second year of the pandemic. MATERIAL AND METHODS: All patients who were hospitalized in the ICUs due to COVID-19 between March 11, 2022, 08.00 am, and March 12, 2022, 08.00 am, were included in the study. Demographic characteristics, intensive care and laboratory data, radiological characteristics, and follow-up results of the patients were recorded. RESULTS: A total of 811 patients from 59 centers were included in the study, 59% of the cases were male, and the mean age was 74 ± 14 years. At least one comorbid disease was present in 94% of the cases, and hypertension was the most common. When ICU weight scores were examined, Acute Physiology and Chronic Health Evaluation-II: 19 (15-27) and Sequential Organ Failure Assessment: 7 (4-10) were seen. Sepsis was present in 37% (n = 298) of cases. PaO2 /FiO2 ratios of the patients were 190 the highest and 150 the lowest and 51% of the cases were followed via invasive mechanical ventilation. On the study day, 73% bilateral involvement was seen on chest x-ray, and ground-glass opacities (52%) were the most common on chest tomography. There was growth in culture in 40% (n = 318) of the cases, and the most common growth was in the tracheal aspirate (42%). CONCLUSION: The clinical course of COVID-19 is variable, and ICU follow-up was required due to advanced age, comorbidity, presence of respiratory symptoms, and widespread radiological involvement. The need for respiratory support and the presence of secondary infection are important issues to be considered in the follow-up. Despite the end of the second year of the pandemic and vaccination, the high severity of the disease as well as the need for follow-up in ICUs has shown that COVID-19 is an important health problem.
Evaluation of Patients with COVID-19 Followed Up in Intensive Care Units in the Second Year of the Pandemic: A Multicenter Point Prevalence Study.
(2023) Güngör, S.; Ediboğlu, Ö.; Moçin, Ö.Y.; Adıgüzel, N.; Tuncay, E.; İşcanlı, İ. G. E.; Er, B.; Karakurt, Z.; Turan, S.; Kosovalı, B.D.; Mutlu, N.M.; Kayar, D.; Gökbulut B.Ş.; Uysal, E.; Seğmen, F.; Alp, G.; Erdem, D.; Has, N.S.; Güven, P.; Özçelik, Z.; Ocakcıoğlu, M.; Özgür, C.Y.; Yılmaz, R.; Özel, D.B.; Cebeci, H.; Güler, B.; Cansever, C.; Çakırca, M.; İnceöz, H.; Solmaz, İ.; Sipahioğlu, F.Ö.; Aydın, E.M.; Dayanır, H.; Öner, S.F.; Karatepe, U.; Özen, S.; Boran, M.; Ergül, D.F.; Kasapoğlu, U.S.; Delen, L.A.; Toy, E.; Altun, K.; Albayrak, T.; Yanal, H.; Zaim, G.; Yarar, V.; Kılınç, G.; Deniz, M.; Özdemir, E.; Soylu, V.G.; Yılmaz, A.; Saygılı, S.M.; Öztürk, E.K.; Ergan, B.; Eyüpoğlu, S.; Şahin, Y.; Yüksel, B.; Bulut, A.; Sarıtaş, A.; Yeniay, H.; Genç, M.; Kargın, F.; Özcan, O.; Karakoç, E.; Karaca, Ü.; Sözütek, D.; Sarı, S.; Şenoğlu, N.; Aygün, H.; Yiğit, A.C.; Kavruk, N.; Uzan, Ç.A.; Bıçakcıoğlu, M.; Solak, S.; Özçelik, H.K.; Uluç, K.; Yıldırım, İ.; Arar, M.C.; Demirel, İ.; Küver, S.U.; Özgür, E.S.; Aydın, K.; Dönmez, G.E.; Aygencel, G.; Esmaoğlu, A.; Aydın, B.S.; Tokur, M.E.; Ekren, P.K.; Aydemir, Y.; Güney, B.Ç.; Erdil, Ö.Y.; Tünay, A.; Bahadır, T.; Uçkun, S.; Kocaoğlu, N.; Pınar, H.U.; Karaca, N,K.; Gültekin, H.; Ayvat, P.; Özer, A.B.; Eroğlu, A.; Kuyrukluyıldız, U.; Baytar, Ç.; Ayoğlu, H.; Mızrakçı, S.; Metin, H.; Mutlu, Ö. P. Z.; Yılmaz, H.; Tüzüner, F.
All patients who were hospitalized in the ICUs due to COVID-19 between March 11, 2022, 08.00 am, and March 12, 2022, 08.00 am, were included in the study. Demographic characteristics, intensive care and laboratory data, radiological characteristics, and follow-up results of the patients were recorded.