Browsing by Author "Merve ZURNACI"

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    TRDizin
    Chemical Composition, Antibacterial and Antioxidant Activities of Thymus Praecox
    (2021-03-01) Pınar BALOĞLU; Kerim GÜNEY; İzzet ŞENER; Fulya TEKELİOĞLU; Merve ZURNACI; Mahmut GÜR
    Aim of Study: It was aimed to determine the chemical composition, antioxidant and antibacterial activityof the Thymus praecox which distributed in the Kastamonu region.Material and methods: Spectroscopic and chromotographic analysis were applied in the determinationof the chemical composition. Thyme extracts were prepared using five different solvents. In Thymuspraecox, the presence of flavonoids using HPLC and the chemical content of essential oil using GC-MSwere investigated. The analyses of the mineral were determined in leaf and stem of thyme by ICP-OES.Antioxidant capacity was determined using two methods such as DPPH free radical scavenging and H2O2scavenging. Antibacterial activity on ten bacteria, Gram (+) and Gram (-) was tested using the disc diffusionmethod.Main results: Experimental results showed that thyme extracts have antibacterial activities against somebacteria. As a result, it was found that the most affected bacteria was S. aureus. Inhibition zone diameterwas determined to be between 8-12 mm. The effect of solvent on antibacterial activity, antioxidant capacity,total phenolic and total flavonoid amounts were observed.Highlights: These results showed that T. praecox has the potential to be used as a natural antimicrobialand antioxidant agent, and can be used as a natural supportive treatment.
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    TRDizin
    Novel 1,3,4-Thiadiazole Derivatives as Antibiofilm, Antimicrobial, Efflux Pump Inhibiting Agents and Their ADMET Characterizations
    (2023-06-30) Mahmut GUR; Eda ALTINOZ; M. Serdar CAVUS; Ergin Murat ALTUNER; Merve ZURNACI; Nesrin SENER; Cigdem SAHIN; Merve SENTURAN; Izzet SENER
    In this study, 1,3,4-thiadiazole derivatives were obtained from the reaction of benzophenone-4,4'-dicarboxylic acid and N-substitute-thiosemicarbazide compounds with each other. After the synthesis of the final products, some biological properties of these compounds such as antibiofilm, antimicrobial and efflux pump inhibiting efficiencies were evaluated. According to the MBC/MFC test, all the activities were found to be bacteriostatic, also, especially the biofilm inhibition activity of C1 against K. pneumoniae is noteworthy. In addition, C4 was observed to exhibit efflux pump inhibition activity in E. coli, whereas C2 and C3 in K. pneumoniae. The absorption and emission values of the molecules were obtained and electrochemical studies were performed. In addition; absorption, metabolism, distribution, excretion and toxicity (ADMET) scores were predicted using the pharmacokinetic properties of all 1,3,4-thiadiazole compounds. Finally, the electrochemical stabilities of the synthesized molecules have been analyzed by using cyclic voltammetry in 0.1 M TBAPF6 in DMSO as a supporting electrolyte.