Browsing by Author "Koc K."
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Scopus (1 → 3)-β-d-glucan enhances the toxicity induced by Bortezomib in rat testis(2020-03-01) Akaras N.; Abuc O.O.; Koc K.; Bal T.; Geyikoglu F.; Atilay H.; Erol H.S.; Yigit S.; Gul M.We aimed to determine the possible effects of the antioxidant agent (1 → 3)-β-D-glucan on bortezomib-induced rat testis damage. We used five groups of rats; control, (1 → 3)-β-D-glucan (75 mg/kg), bortezomib group, bortezomib + (1 → 3)-β-D-glucan groups (injection of (1 → 3)-β-D-glucan after bortezomib and sacrificed at 48th or 72nd h). The effects of these substances were assessed by measuring the levels of the antioxidant enzymes and LPO, and by performing immunohistochemical analysis with NF-κB. The histology of testis was evaluated using aniline blue staining. (1 → 3)-β-D-glucan leads to significant reductions in the levels of antioxidant enzymes and increased levels of LPO in testes. Moreover, it increased the NF-κB immunopositivity significantly in testis, especially in Bortezomib + (1 → 3)-β-D-glucan group at 48th h. The histological changes were observed in the bortezomib and/or (1 → 3)-β-D-glucan groups. Our results demonstrated that testis damage caused by the treatment with bortezomib was not eliminated by (1 → 3)-β-D-glucan and shockingly it increased the damage. Practical applications: The testis damage caused by the treatment with bortezomib was not eliminated by (1 → 3)-β-D-glucan and as a result, β-1,3-(D)-glucan enhanced the toxicity by leading a decrease in the levels of GSH, SOD, and CAT, thus caused an elevation in the immunoreactivity of NF-κB and altered the histopathological changes by enhancing the toxic effects of bortezomib. The findings of the previous studies about the antioxidative activity of (1 → 3)-β-D-glucan are controversial. So, it is necessary to consider the cytotoxicity of (1 → 3)-β-D-glucan in testis tissue. Thus, more studies on testis tissue are necessary to confirm that (1 → 3)-β-D-glucan is safe as an antioxidant.Scopus Convergence of per capita ecological footprint among BRICS-T countries: evidence from Fourier unit root test(2023-01-01) Bayraktar Y.; Koc K.; Toprak M.; Ozyılmaz A.; Olgun M.F.; Balsalobre-Lorente D.; Soylu O.B.In recent years there has been a great deal of research into environmental pollution using a variety of techniques in response to growing environmental concerns. Convergence analysis, one of these techniques, helps determine whether the developing countries will catch up with the rich countries in pollution using unit root tests. However, the vast majority of the research in the field has generally used conventional unit root tests. Since many economic series contain structural breaks, using unit root tests that account for structural breaks is essential for accurate prediction. More specifically, if the series has a fractional process, conventional unit root tests may erroneously conclude that the departure from linearity is permanent. Moreover, the existing literature mainly uses gas emissions, such as carbon dioxide, which represent pollution weakly. Therefore, we use per capita ecological footprint (EF hereafter) as a more comprehensive pollution indicator of environmental degradation. In this direction, the study aims to determine whether BRICS-T countries' EF converges to the average of the BRICS-T for the 1992–2017 period. Besides the ADF unit root test, we employed the Fourier ADF unit root test, which considers the structural breaks, and the Fractional Frequency Fourier ADF unit root test, which accounts for structural breaks by considering fractional values. Our results showed that EF converges in Russia and Turkey according to the conventional ADF test, in China and Russia according to the Fourier ADF test, and in Brazil and China according to the Fractional Fourier Frequency test.Scopus Hispidulin exerts a protective effect against oleic acid induced-ARDS in the rat via inhibition of ACE activity and MAPK pathway(2023-01-01) Koc K.; Ozek N.S.; Aysin F.; Demir O.; Yilmaz A.; Yilmaz M.; Geyikoglu F.; Erol H.S.This study investigates the protective role of Hispidulin on acute respiratory distress syndrome (ARDS) in rats. Rats were divided into three groups: control, ARDS, ARDS+ Hispidulin. The ARDS models were established by injecting rats with oleic acid. Hispidulin (100 mg/kg) was injected i.p. an hour before ARDS. Myeloperoxidase (MPO), Interleukin-8 (IL-8), Mitogen-activated protein kinases (MAPK), Lipid Peroxidation (LPO), Superoxide Dismutase (SOD), Glutathione (GSH), and Angiotensin-converting enzyme (ACE) were determined by ELISA. Tumor necrosis factor-alpha (TNF-α) expression was described by RT-qPCR. Caspase-3 immunostaining was performed to evaluate apoptosis. Compared with the model group, a significant decrease was observed in the MPO, IL-8, MAPK, ACE, LPO levels, and TNF-α expression in the ARDS+ Hispidulin group. Moreover, reduced caspase-3 immunoreactivity and activity of ACE were detected in the Hispidulin+ARDS group. The protective effect of Hispidulin treatment may act through inhibition of the ACE activity and then regulation of inflammatory cytokine level and alteration of apoptosis.