Browsing by Author "Kiran, B"
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Web of Science Anti-proliferative, apoptotic and signal transduction effects of hesperidin in non-small cell lung cancer cells(2015.01.01) Cincin, ZB; Unlu, M; Kiran, B; Bireller, ES; Baran, Y; Cakmakoglu, BWeb of Science Apoptotic Effects of Quercitrin on DLD-1 Colon Cancer Cell Line(2015.01.01) Cincin, ZB; Unlu, M; Kiran, B; Bireller, ES; Baran, Y; Cakmakoglu, BWeb of Science Assessment of Association Between the Potential Immunomodulatory Activity and Drinking Olive Leaf Tea in the Coronavirus Disease-2019 Pandemic: An Observational Study(2022.01.01) Kocyigit, A; Guler, EM; Irban, A; Kiran, B; Atayoglu, ATWeb of Science Chemical Composition and Antimicrobial Activities of Cold-Pressed Oils Obtained From Nettle, Radish and Pomegranate Seeds(2018.01.01) Altuner, EM; Ceter, T; Gur, M; Guney, K; Kiran, B; Akwieten, HE; Soulman, SIWeb of Science DETERMINATION OF FLAVONOIDS AND ANTIMICROBIAL BEHAVIOR OF NON-WOOD FOREST PRODUCT EXTRACTS(2018.01.01) Kiran, B; Olgun, C; Verep, D; Gur, M; Guney, K; Altuner, EM; Ates, SWeb of Science EFFECTS OF HESPERIDIN ON NON-SMALL CELL LUNG CANCER CELLS(2014.01.01) Bireller, ES; Cincin, ZB; Unlu, M; Kiran, B; Baran, Y; Cakmakoglu, BWeb of Science Hesperidin promotes programmed cell death by downregulation of nongenomic estrogen receptor signalling pathway in endometrial cancer cells(2018.01.01) Cincin, ZB; Kiran, B; Baran, Y; Cakmakoglu, BPubmed Hesperidin promotes programmed cell death by downregulation of nongenomic estrogen receptor signalling pathway in endometrial cancer cells.(2018-07-01T00:00:00Z) Cincin, Z B; Kiran, B; Baran, Y; Cakmakoglu, BEndometrial carcinoma (EC) is the most common malignant gynecologic tumor in women. EC is thought to be caused by increasing estrogen levels relative to progesterone in the body. Hesperidin (Hsd), a biologically active flavonoid, could be extracted from Citrus species. It has been recently shown that Hsd could exert anticarcinogenic properties in different cancer types. However, the effects of Hsd and its molecular mechanisms on EC remain unclear. In this study, the antiproliferative, apoptotic and genomic effects of Hsd in EC and its underlying mechanisms were identified. We found that Hsd significantly suppressed the proliferation of EC cells in dose and time dependent manner. Mechanistic studies showed that Hsd could contribute apoptosis by inducing externalization of phosphatidyl serine (PS), caspase-3 activity and loss of mitochondrial membrane (MMP). Furthermore, we examined that Hsd could also significantly upregulate the expression of proapoptotic Bax subgroup genes (Bax and Bik) while downregulating the anti-apoptotic protein Bcl-2 in EC cell lines. According to GO enrichment and KEGG pathway analysis of differentially expressed genes in Hsd treated EC cells, we identified that Hsd could promote cell death via downregulation of estrogen receptor I (ESRI) that was directly related to ERK/MAPK pathway. Taken together, our study first showed that Hsd could be an antiestrogenic compound that could modulate nongenomic estrogen receptor signaling through inhibition of EC cell growth. Our findings may provide us a novel growth inhibitory agent for EC treatment after verifying its molecular mechanism with in vivo studies.Web of Science Individual and Combined Effects of CTLA4-CD28 Variants and Oxidant-Antioxidant Status on the Development of Colorectal Cancer(2015.01.01) Kucukhuseyin, O; Turan, S; Yanar, K; Arikan, S; Duzkoylu, Y; Aydin, S; Cakatay, U; Mezani, B; Farooqi, AA; Isitmangil, GA; Kiran, B; Cacina, C; Yenilmez, EN; Ergen, A; Zeybek, U; Yaylim, IWeb of Science Interleukin-12 and Protamine Inhibit Angiogenesis and Growth of C6 Rat Glioma: Synergistic Effects and Role of Th2 Cells(2013.01.01) Turna, A; Kiran, B; Ozar, E; Turna, H; Mercan, CA; Buyukpinarbasili, N; Bilir, A; Deniz, GWeb of Science Is there any possibility that selenium and homocysteine play a role in metastatic ability of colorectal tumors?(2020.01.01) Horozoglu, C; Rajab, BMM; Turan, S; Erbasoglu, OK; Kucukhuseyin, O; Hakan, MT; Kiran, B; Dogan, MB; Arikan, S; Yaylim, IWeb of Science Molecular Mechanisms of Quercitrin-induced Apoptosis in Non-small Cell Lung Cancer(2014.01.01) Cincin, ZB; Unlu, M; Kiran, B; Bireller, ES; Baran, Y; Cakmakoglu, BWeb of Science Predicting the predisposition to colorectal cancer based on SNP profiles of immune phenotypes using supervised learning models(2023.01.01) Cakmak, A; Ayaz, H; Arikan, S; Ibrahimzada, AR; Demirkol, S; Sonmez, D; Hakan, MT; Surmen, ST; Horozoglu, C; Dogan, MB; Kucukhuseyin, O; Cacina, C; Kiran, B; Zeybek, U; Baysan, M; Yaylim, IWeb of Science The effect of CTLA-4 and CD28 gene variants and circulating protein levels in patients with gastric cancer(2017.01.01) Arikan, S; Gumus, A; Kucukhuseyin, O; Coskun, C; Turan, S; Cacina, C; Talu, CK; Akyuz, F; Farooqi, AA; Kiran, B; Yaylim, IWeb of Science The Role of Activated Cytotoxic T Cells in Etiopathogenesis of Periodontal Disease: Does It Harm or Does It Heal?(2015.01.01) Cifcibasi, E; Ciblak, M; Kiran, B; Badur, S; Firatli, E; Issever, H; Cintan, S