Browsing by Author "Ilgaz AKATA"

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Anti-Biofilm and Antimicrobial Activities of Five Edible and Medicinal Macrofungi Samples on Some Biofilm Producing Multi Drug Resistant Enterococcus Strains
(2020-12-01) Başar KARACA; Ilgaz AKATA; Arzu ÇÖLERİ CİHAN; Ergin Murat ALTUNER
It is commonly well-known that biofilms are the predominant mode of bacterial growth, reflected in the clinic observations, where approximately 80% of all bacterial infections are related to biofilms. Bacteria in biofilms are well protected against environmental stresses, antibiotics, disinfectants and the host’s immune system and are usually extremely difficult to eradicate. Due to common problems caused by biofilms, alternative anti-biofilm strategies must be developed. Enterococcus strains are able to form complex surface-associated communities (biofilms), which contribute to its resistance and persistence in both host and non-host environments, and are especially important in food processing and clinical environments. Enterococcus biofilms showed increased antimicrobial resistance to the most of antibiotics as compared to the planktonic bacteria, which make them difficult to combat. There is an increasing evidence that biofilms are often associated with infectious diseases. Novel anti-biofilm strategies must be designed to include natural bio products instead of common antibiotics. Mushrooms are a nutritionally functional foods and a source of pharmaceuticals having functions such as antitumor, immunomodulating, antioxidant, cardiovascular, anti-hypercholesterolemia, antiviral, antibacterial, anti-parasitic, antifungal, detoxification, hepatoprotective, and antidiabetic. In addition, they have a notable activity against biofilms. In this study, the antimicrobial and anti-biofilm activities of some medicinal and edible mushrooms, namely Morchella angusticeps Peck, Ganoderma lucidum (Curtis) P. Karst., Cerioporus squamosus (Huds.) Quél., Trametes versicolor (L.) Lloyd and Lentinula edodes (Berk.) Singer were screened against multi drug resistant Enterococcus strains. As a result, it was observed that these mushrooms have notable potency to develop alternative medicines to struggle infectious diseases and biofilms.
In vitro antimicrobial activity screening of bovista nigrescens Pers.
(2012-05-01) Ilgaz AKATA; Ergin Murat ALTUNER; Kerem CANLI
Bu çalışmanın amacı, Bovista nigrescense ait etanol ekstraktlarının 17 bakteri, 1 mantar suşuna karşı gösterdiği antimikrobiyal aktivitenin incelenmesidir. Yomra, Çamlıyurt, Trabzon, Türkiyeden toplanan B. nigrescens örnekleri kurutulduktan sonra etanol ile ekstraksiyona tabi tutulmuştur. Bu ekstraktların; Bacillus subtilis ATCC 6633, Candida albicans ATCC 10231, Enterobacter aerogenes ATCC13048, Enterococcus durans, Enterococcus faecalis ATCC 29212, Enterococcus faecium, Escherichia coli ATCC 25922, Escherichia coli CFAI, Klebsiella pneumoniae, Listeria monocytogenes ATCC 7644, Salmonella enteritidis ATCC 13075, Salmonella infantis, Salmonella kentucky, Salmonella typhimurium SL 1344, Staphylococcus aureus ATCC 25923, Staphylococcus carnosus MC1.B, Staphylococcus epidermidis DSMZ 20044 ve Streptococcus agalactiae DSMZ 6784 gibi geniş yelpazedeki suşlara karşı in vitro antimikrobiyal aktiviteleri disk difüzyon yöntemi kullanılarak incelenmiştir. B. nigrescensin etanol ekstraktlarının bazı gram negatif ve gram pozitif mikroorganizmaya etki ettiği gözlenmiştir. Bu çalışmanın sonucu olarak B. nigrescensin etanol ekstraktarının bazı mikroorganizmalar üzerine aktivite gösterdiği, ancak B. subtilis, K. pneumoniae ve S. carnosus üzerine gösterdiği etkinin dikkat çekici olduğu sonucuna varılmıştır.