Browsing by Author "Gür M., Şener N., Kaştaş Ç.A., Özkan O.E., Muğlu H., Elmaswari M.A.M."

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    Synthesis and Characterization of Some New Heteroaromatic Compounds Having Chirality Adjacent to a 1,3,4-Thiadiazole Moiety and Their Antimicrobial Activities
    (2017-11-01) Gür M., Şener N., Kaştaş Ç.A., Özkan O.E., Muğlu H., Elmaswari M.A.M.; Gur, M, Sener, N, Kastas, CA, Ozkan, OE, Muglu, H, Elmaswari, MAM
    Through a cyclization reaction of 2-phenylbutyric acid with N-phenylthiosemicarbazide and POCl3, novel 1,3,4-thiadiazole derivatives were synthesized. Their structures were confirmed using IR, 1H NMR, and 13C NMR spectroscopies and elemental analysis. The antibacterial activities of the obtained 1,3,4-thiadiazole derivatives were tested against Gram-negative bacteria (Salmonella enteritidis, Salmonella typhimurium, Enterobacter aerogenes, Salmonella infantis, Salmonella kentucky, and Escherichia coli) and Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis, and Enterococcus durans) using a disk diffusion method. Moreover, an antifungal activity experiment was performed against Candida albicans using the disk diffusion method. It was observed that the synthesized 1,3,4-thiadiazole derivatives exhibited effective antimicrobial activity against S. aureus, E. coli, and C. albicans. Based on these results, the 1,3,4-thiadiazole derivatives can be considered as a source of bioactive agents for pharmacological and medicinal applications.