Browsing by Author "Gülbagca, Fulya"

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    Biogenic platinum nanoparticles using black cumin seed and their potential usage as antimicrobial and anticancer agent.
    (2020-02-05T00:00:00Z) Aygun, Aysenur; Gülbagca, Fulya; Ozer, Lutfiye Yildiz; Ustaoglu, Buket; Altunoglu, Yasemin Celik; Baloglu, Mehmet Cengiz; Atalar, Mehmet Nuri; Alma, Mehmet Hakkı; Sen, Fatih
    Herein, the biogenic platinum nanoparticles (Pt NPs) were synthesized by using black cumin seed (Nigella sativa L.) extract as a reducing agent. The biogenic platinum nanoparticles synthesized by black cumin seed extract was characterized in detail by Transmission Electron Microscopy (TEM), UV-vis spectrophotometer, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS). According to TEM analysis, Pt nanoparticles have spherical shapes and sizes between 1-6 nm. Moreover, the biogenic Pt NPs was assessed for its cytotoxicity effect on MDA-MB-231 breast and HeLa cervical cancer lines and their antibacterial effect against selected strains of gram-positive and negative bacteria. The cytotoxicity and bacterial tests showed the effectiveness of biogenic Pt nanoparticles. Dose-dependent toxicity effects were shown in the MDA-MB-231 breast and HeLa cervical cancer lines (IC50: 36.86 μg/mL and 19.83 μg/mL, respectively). In addition, Pt NPs showed high zone diameters against gram-positive and gram-negative bacteria at concentrations of 100 and 500 μg/ml. These results contribute to the development of the pharmaceutical industry as a potential antibacterial and anticancer agent.