Browsing by Author "Demir O."
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Scopus Effects of dietary fish oil replacement by unrefined peanut oil on the growth, serum biochemical and hematological parameters of Mozambique tilapia juveniles (Oreochromis mossambicus)(2014-01-01) Demir O.; Türker A.; Acar Ü.; Kesbiç O.This research aimed to evaluate the effects of partial or total replacement of fish oil (FO) with unrefined peanut oil (PO) on growth and some physiological parameters of Mozambique tilapia juveniles for 60 days. Three triplicate groups (initial weight 6.36±0.19 g) were fed with isoenergetic and isonitrogenous diets in which FO was replaced with PO in graded increments of 50% (PO0, PO50, PO100). The results showed that weight gain and feed efficiency of fish fed with PO50 diet were statistically higher than in the other two groups (P<0.05). No significant effects were observed on whole body proximate composition of fish fed with the experimental diets (P>0.05). The partial or total replacement of FO with PO did not affect on the hematological and immunological parameters of fish. Serum glucose, total cholesterol and triglyceride were lower in fish fed with PO50 diet (P<0.05). The present study revealed that PO can be used as an alternate source of dietary lipid up to 50% in tilapia feeds without adverse effects on growth performance, hemato-immunological and serum biochemical parametersScopus Hispidulin exerts a protective effect against oleic acid induced-ARDS in the rat via inhibition of ACE activity and MAPK pathway(2023-01-01) Koc K.; Ozek N.S.; Aysin F.; Demir O.; Yilmaz A.; Yilmaz M.; Geyikoglu F.; Erol H.S.This study investigates the protective role of Hispidulin on acute respiratory distress syndrome (ARDS) in rats. Rats were divided into three groups: control, ARDS, ARDS+ Hispidulin. The ARDS models were established by injecting rats with oleic acid. Hispidulin (100 mg/kg) was injected i.p. an hour before ARDS. Myeloperoxidase (MPO), Interleukin-8 (IL-8), Mitogen-activated protein kinases (MAPK), Lipid Peroxidation (LPO), Superoxide Dismutase (SOD), Glutathione (GSH), and Angiotensin-converting enzyme (ACE) were determined by ELISA. Tumor necrosis factor-alpha (TNF-α) expression was described by RT-qPCR. Caspase-3 immunostaining was performed to evaluate apoptosis. Compared with the model group, a significant decrease was observed in the MPO, IL-8, MAPK, ACE, LPO levels, and TNF-α expression in the ARDS+ Hispidulin group. Moreover, reduced caspase-3 immunoreactivity and activity of ACE were detected in the Hispidulin+ARDS group. The protective effect of Hispidulin treatment may act through inhibition of the ACE activity and then regulation of inflammatory cytokine level and alteration of apoptosis.