Browsing by Author "Cinar, I, Yayla, M, Celik, M, Bilen, A, Bayraktutan, Z"

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    Role of Endothelin 1 on Proliferation and Migration of Human MCF-7 Cells.
    (2020-10-01T00:00:00Z) Cinar, Irfan, Yayla, Muhammed, Celik, Muhammet, Bilen, Arzu, Bayraktutan, Zafer; Zafer BAYRAKTUTAN, Muhammet ÇELİK, Arzu BİLEN, İrfan ÇINAR, Muhammed YAYLA; Cinar, I, Yayla, M, Celik, M, Bilen, A, Bayraktutan, Z
    The aim of this study was to explore the role of endothelin 1 (ET-1) in human breast cancer proliferation and migration and antagonism of endothelin receptor A (ETAR) and endothelin receptor B (ETBR) by using the non-selective dual ETA/ETB receptor antagonist bosentan and determine its anti-proliferative, anti-metastatic, and apoptotic effects demonstrated by nuclear factor kappa B (NF-kB), vascular endothelial growth factor (VEGF), Caspase 3 and Caspase 9 expression on endothelin-induced proliferation of MCF-7 cell line in vitro.