Browsing by Author "Bulut M."

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Epidemiologic and clinical characteristics of neonates with late-onset COVID-19: 1-year data of Turkish Neonatal Society
(2022-05-01) Akin I.M.; Kanburoglu M.K.; Tayman C.; Oncel M.Y.; Imdadoglu T.; Dilek M.; Yaman A.; Narter F.; Er I.; Kahveci H.; Erdeve O.; Koc E.; Yildiz E.; Melekoglu N.A.; Okulu E.; Toptan H.H.; Surmeli O.; Can E.; Yilmaz F.H.; Ozkan H.; Caner I.; Cömert S.; Uygun S.S.; Akbay S.; Memisoglu A.; Anik A.; Arcagok B.C.; Karagol B.S.; Ates M.; Bulut M.; Akin M.A.; Demir N.; Ozdemir R.; Arayici S.; Kader S.; Zubarioglu A.U.; Oktem A.; Bulbul A.; Hekimoglu B.; Ataoglu E.; Baser D.O.; Yalinbas E.E.; Imamoglu E.Y.; Ozlu F.; Bilgin L.; Kefeli M.; Arslan M.K.; Akar S.; Bezirganoglu H.; Bozdag S.; Gurpinar R.; Ciftdemir N.A.; Ozdemir O.M.
The literature on neonates with SARS-CoV-2 is mainly concerned with perinatal cases, and scanty data are available about environmentally infected neonates. To fill knowledge gaps on the course and prognosis of neonatal cases, we analyzed 1-year data from the Turkish Neonatal Society in this prospective cohort study of neonates with postnatal transmission. Data from 44 neonatal intensive care units (NICUs), of neonates with positive RT-PCR results at days 5–28 of life, were extracted from the online registry system and analyzed. Of 176 cases, most were term infants with normal birth weight. Fever was the most common symptom (64.2%), followed by feeding intolerance (25.6%), and cough (21.6%). The median length of hospitalization was 9 days, with approximately one quarter of infants receiving some type of ventilatory support. Myocarditis (5.7%) was the most common complication during follow-up. Among the clinical findings, cough (odds ratio [OR]: 9.52, 95% confidence interval [CI]: 4.17–21.71), tachypnea (OR: 26.5, 95% CI: 9.59–73.19), and chest retractions (OR: 27.5, 95% CI: 5.96–126.96) were associated with more severe clinical disease. Also, there were significant differences in the C-reactive protein level, prothrombin time (PT), partial thromboplastin time, international normalized ratio, and days in the NICU (p = 0.002, p = 0.012, p = 0.034, p = 0.008, and p < 0.001, respectively) between patients with mild-moderate and severe-critical presentations. A PT above 14 s was a significant predictor of severe/critical cases, with a sensitivity of 64% and specificity of 73%. Conclusions: Our data showed that late-onset COVID-19 infection in neonates who need hospitalization can be severe, showing associations with high rates of ventilatory support and myocarditis. Cough, tachypnea, and retractions on admission suggest a severe disease course. Trial registration: ClinicalTrials.gov identifier: NCT04401540.What is Known:• Neonatal cases of COVID-19 infection are mainly reported as perinatal COVID-19 cases.• Neonates with perinatal transmission have a mild course and favorable prognosis.What is New:• Among symptomatic neonates with late-onset COVID-19 infection, fever was the most common symptom, and almost one quarter of hospitalized cases needed some type of respiratory support. Myocarditis was the most common complication.• The presence of cough, tachypnea, retractions, and a PT above 14 s were associated with an increased risk of severe COVID-19.
Evaluation of dietary protein and lipid requirements of two-banded seabream (Diplodus vulgaris) cultured in a recirculating aquaculture system
(2014-01-01) Bulut M.; Yiğit M.; Ergün S.; Kesbiç O.; Acar U.; Gültepe N.; Karga M.; Yılmaz S.; Güroy D.
The objective of this study is to investigate the effects of dietary protein and lipid levels on the growth performance and bioeconomic benefits of two-banded seabream (Diplodus vulgaris) juveniles, a candidate species for aquaculture sector. Eight experimental diets were formulated with four protein (50, 45, 40 and 35 %) levels for each of the two lipid levels (15 and 10 %). Triplicate groups of juvenile fish with an average initial body weight of ~3.64 g were reared in a recirculating aquaculture system and hand fed twice a day until satiation for a period of 60 days. In the experiment, no difference in survival rate was found between the different groups. Relative growth rate (RGR), specific growth rate (SGR), feed conversion ratio (FCR) and daily feed intake were not significantly affected by increasing protein and/or lipid treatments in this present study. However, the RGR, SGR and FCR values showed slightly better efficiency in the experimental group (35/15) fed with lower protein content (35 %) and higher lipid level (15 %) compared with those fed other diets. According to bioeconomic analyses results, the diet with the 35 % protein and 15 % lipid generated the best profit. The results suggest that two-banded seabream can be accepted as a promising alternative species for the aquaculture industry and optimum growth of two-banded seabream fingerlings can be obtained when they are fed a diet containing 35 % crude protein and 15 % crude lipid. © 2013 Springer Science+Business Media Dordrecht.
Evaluation of Dietary Protein Level in Practical Feed for Twoband Bream Diplodus vulgaris
(2018-10-01) Yigit M.; Sahinyilmaz M.; Acar Ü.; Kesbic O.; Yilmaz S.; Bulut M.; Gürses K.; Maita M.
The effects of different dietary protein levels on growth performance and health status of TwobandBream Diplodus vulgaris juveniles were investigated. Three test diets that had increasing protein levels (30, 36, and 42%) and used fish meal as the protein source were formulated. Each of the test diets was fed in triplicate groups of 28 juvenile fish (initial weight, 23.65 ± 0.34 [mean ± SD]) to satiety for a period of 80 d. Growth performance and feed utilization were best in the group fed the diet with a protein level of 36%. Ammonia nitrogen excretion showed an increasing trend as dietary protein levels increased, and retention rates of ammonia nitrogen per intake were highest in fish fed the 42% protein diet. Whole-body proximate composition and hematological variables were not significantly affected by protein level in the diets. However, serum glucose, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) values were significantly affected by dietary protein level and showed an increasing trend as the dietary protein level in the diets increased. As a result, an improved health status of Twoband Bream was observed in the fish fed a 36% protein level.
Human exposure to trace elements via farmed and cage aggregated wild Axillary seabream (Pagellus acarne) in a copper alloy cage site in the Northern Aegean Sea
(2018-12-01) Yigit M.; Dwyer R.; Celikkol B.; Yilmaz S.; Bulut M.; Buyukates Y.; Kesbic O.S.; Acar Ü.; Ozalp B.; Maita M.; Ergün S.
Axillary seabream (Pagellus acarne) farmed in a copper alloy mesh pen and wild individuals of P. acarne aggregated near the copper-alloy cages presented higher concentrations of trace metals in the liver, skin and gills than in fish muscle tissues in two batches of small and large fish sizes. Elevated mean levels of metals (mg kg−1) in muscle tissues in both small and large fish size groups were observed in the rank order of Zn(3.43) > Fe(3.01) > Cu(0.59) > Mn(0.13) and Fe(3.82) > Zn(3.32) > Cu(0.62) > Mn(0.17) for copper cage-farmed fish, relative to ranked mean levels for Zn(2.64) > Fe(1.95) > Cu(0.25) > Mn(0.09) and Fe(5.79) > Zn(3.58) > Cu(0.58) > Mn(0.28) for the copper cage-aggregated wild fish. Nevertheless, trace metal concentrations in fish harvested from the copper cage or those of the cage-aggregated wild individuals in both size groups were far below maximum levels of seafood safety recommended by USEPA and FAO/WHO. Target hazard quotients, calculated to estimate the non-carcinogenic health risks of metals by consuming these fish, were below “1″ (THQ < 1), indicating that there were no potential health risks for humans when consuming copper-caged fish or wild-caught individuals aggregated around the copper mesh pen, with respect to the limits suggested by US Food and Drug Administration and EU Regulations for Seafood Consumption.
Morphological malformations of the sea bass (Dicentrarchus labrax): Comparison between hormone injected and noninjected fish
(2015-01-01) Tan S.; Bulut M.; Bilen S.
In this study, fertilization, hatching and deformation rate of the eggs, and larvae obtained from hormone injected (HI) and non-injected broodstock (NHI), were determined. In the experiment, no differences were observed in the groups' fertilization rates (p>0.05). Hatching rate was found higher in the HI group (p<0.05). During the experiment, malformations such as spinal fluid accumulation, saddleback, air-bladder deformation and general body deformations were observed in both groups. For the NHI group, saddleback rate was found 5.13±0.55 %, air-bladder deformation rate was found 1.43±0.13%, spinal fluid accumulation was found 2.33±1.33% and general body deformation rate was found 3.76±0.23 % (p<0.05). As a result, it was determined that the deformation rate increased with hormone injection (p<0.05).
Temporal Variations in Hematological, Immunological and Serum Biochemical Parameters of Rainbow Trout (Oncorhynchus mykiss) Acclimated to High-Saline Water in the Northern Aegean Sea
(2023-01-01) Buyukates Y.; Kesbiç O.; Yigit M.; Yilmaz S.; Ergün S.; Bulut M.; Ozalp B.
The present study evaluated the health status of rainbow trout (30.24±5.34 g) acclimated to high-saline water (28‰). Among adaptation procedures, gradually-acclimated (for 48 h) fish showed best performance, which were then introduced to the offshore cage-farm for further monitoring of fish health in marine environment over a long-term period of 100 days, until harvest weight of 319.9±48.51 g. Fish health and welfare was evaluated by means of biochemical parameters (viscerasomatic index, hepatosomatic index, mesenteric fat index, and spleen somatic index), hematological parameters (serum glucose, triglyceride, cholesterol, total protein, albumin, globulin), and immune parameters (lysozyme, myeloperoxidase, respiratory burst and potential killing values). Gradual acclimation to high-saline water did not show any adverse effects on health parameters. No significant differences were found in biometric measures (P>0.05). However, a time-dependent increase was recorded in hematology markers (P<0.05) after seawater transfer, and the health status improved over long term from March 7 to June 14, 2018. All serum biochemical markers, except the total protein showed significant alterations (P<0.05) in long term but without detrimental influence by day 100. Therefore, it seems possible to expand trout farms from brackish water sites to higher saline environments up to 28‰ salinity, with no detrimental impacts on fish health, that in turn may significantly contribute to the extension of potential aquaculture sites to wider areas.
Unrefined Peanut Oil as a Lipid Source in Diets for Juveniles of Two-banded Seabream Diplodus vulgaris
(2016-01-02) Kesbiç O.S.; Acar Ü.; Yigit M.; Bulut M.; Gültepe N.; Yilmaz S.
A feeding study with Two-banded Seabream Diplodus vulgaris was conducted to determine the effects of replacement of fish oil (FO) by unrefined peanut oil (PO) on growth performance, feed utilization, body composition, fatty acid composition, and serum biochemical and hematological variables. Three isonitrogenous (35.8%) and isoenergetic (21.15 kJ/g) diets were formulated by replacing dietary FO with PO at levels of level 0% (PO0), 50% (PO50), or 100% (PO100). Fish were fed twice a day until satiation for an experimental period of 8 weeks. The best growth performance was observed in fish fed with the PO0 and PO50 diets. A significant increase was observed in hematocrit and mean corpuscular volume levels of fish fed with PO50 diet compared with the other groups. Hemoglobin, mean corpuscular hemoglobin, total protein, albumin, and globulin were not affected by dietary PO treatment and did not differ among experimental groups. The glucose level was highest in the PO100 group. Triglyceride and cholesterol levels were lower in fish fed diets with PO inclusions than in those fed the control diet. The fatty acid composition of fish was significantly affected by the experimental diets. Glutamic oxaloacetic transaminase, glutamic pyruvictransaminase, lactate dehydrogenase, and alkaline phosphatase were not affected by dietary PO treatment. The n-3:n-6 ratio in fish fed the PO0 diet was also higher than in fish fed the PO-supplemented diets. The results of the present study showed that FO could be substituted by PO up to 50% in Two-banded Seabream diets without any negative effect on growth performance or serum biochemical and hematological features.