Browsing by Author "Bozyel, Mustafa Eray"

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Antimicrobial Activity Screening of Ethanol Extract of and Investigation of Its Biochemical Composition.
(2019-01-10) Canlı, Kerem; Yetgin, Ali; Benek, Atakan; Bozyel, Mustafa Eray; Murat Altuner, Ergin
The aim of this study was to test antimicrobial activity of ethanol extract of against 22 bacteria and 1 yeast. Also, biochemical composition of the extract was investigated. A wide range of Gram-positive, Gram-negative microorganisms, and multidrug resistant bacteria were selected to test the antimicrobial activity. As a result, the extract is observed to contain fenchone )-) and camphor as major components and showed antimicrobial activity against all studied microorganisms except ATCC 25922 and . The results of the study present that is active against MDR strains too.
Biochemical and Antioxidant Properties as well as Antimicrobial and Antibiofilm Activities of subsp. (Vved.) Stearn.
(2023-06-06T21:00:00Z) Canli, Kerem; Turu, Dilay; Benek, Atakan; Bozyel, Mustafa Eray; Simsek, Özcan; Altuner, Ergin Murat
In this study, the chemical composition and biological activity of subsp. (Vved.) Stearn were investigated for the first time, focusing on its antimicrobial, antioxidant, and antibiofilm properties. A GC-MS analysis was employed to evaluate the composition of its secondary metabolites, identifying linoleic acid, palmitic acid, and octadecanoic acid 2,3-dihydroxypropyl ester as the major compounds in ethanol extract. The antimicrobial activity of subsp. was assessed against 26 strains, including standard, food isolate, clinical isolate, and multidrug-resistant ones, as well as three species using the disc diffusion method and the determination of the minimum inhibitory concentration (MIC). The extract showed strong antimicrobial activity against strains, including methicillin-resistant and multidrug-resistant strains, as well as and . Its antioxidant capacity was evaluated using the DPPH method, revealing a high level of antioxidant activity in the plant. Additionally, the antibiofilm activity of subsp. was determined, demonstrating a reduction in biofilm formation for the ATCC 25922 strain and an increase in biofilm formation for the other tested strains. The findings suggest potential applications of subsp. in the development of novel antimicrobial, antioxidant, and antibiofilm agents.
Biochemical, Antioxidant Properties and Antimicrobial Activity of Steno-Endemic .
(2023-08-02) Canli, Kerem; Bozyel, Mustafa Eray; Turu, Dilay; Benek, Atakan; Simsek, Ozcan; Altuner, Ergin Murat
(Lamiaceae) is an Eastern Mediterranean plant that is widely used in Turkish traditional medicine. This study aimed to investigate the biochemical composition, antimicrobial activity, and antioxidant potential of . In this study, the biochemical composition of the ethanol extract (OOEt) was analyzed using GC-MS. The antimicrobial activity was investigated using a disk diffusion test and determining minimum inhibitory concentrations (MIC) against 30 microorganism strains, including 28 bacteria (some multidrug-resistant) and 2 fungi. Additionally, the antioxidant activity was evaluated using the DPPH method. The main component identified was carvacrol. OOEt demonstrated antimicrobial activity against a wide range of tested microorganism strains. OOEt displayed the highest activity against (a Gram-positive bacterium) at 100 µL with a 52 mm inhibition zone. Additionally, DSMZ 50071 and P1, which are Gram-negative bacteria, were the most sensitive strains with a 24 mm inhibition zone in 100 µL of OOEt. The data obtained from (a multidrug-resistant strain) is particularly striking, as higher activity was observed compared to all positive controls. All tested fungal strains showed more effective results than positive controls. The antioxidant activity of OOEt was found to be stronger than that of the positive control, ascorbic acid. This study determined that has significant antimicrobial and antioxidant potential.
Biological Activities and Biochemical Composition of Endemic .
(2023-04-09T00:00:00Z) Tunca-Pinarli, Yagmur; Benek, Atakan; Turu, Dilay; Bozyel, Mustafa Eray; Canli, Kerem; Altuner, Ergin Murat
In this study, we investigated the antimicrobial, antioxidant, and antibiofilm activities and the biochemical composition of . The antimicrobial activity of ethanol extract (AFEt) was tested against 48 strains, and this is the first study testing the antimicrobial activity of this plant to this extent. The antioxidant activity was determined using the DPPH assay, and the antibiofilm activity of aqueous extract (AFAq) against five strains was assessed. The chemical composition of the plant extract was determined using GC-MS with artemisia ketone (19.41%) as the main component. The findings indicated that AFEt displayed antimicrobial activity against 38 strains, with a particular efficacy observed against various strains, such as ATCC 25923, clinically isolated, multidrug resistant (MDR), and methicillin-resistant (MRSA) strains. In addition, the highest activity was observed against . Moreover, the extract demonstrated activity against strains. The plant extract also showed relatively good antioxidant activity compared to ascorbic acid, with an value of 55.52 µg/mL. However, AFAq acted as a biofilm activator against ATCC 25922, increasing the biofilm formation by 2.63-fold. In conclusion, our study demonstrates the potential of as a source of antimicrobial and antioxidant agents.