Browsing by Author "Bayram KIRAN"

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    Chemical Composition and Antimicrobial Activities of Cold-Pressed Oils Obtained From Nettle, Radish and Pomegranate Seeds
    (2018-12-01) Sana I. SOULMAN; Hana Ealoma AKWIETEN; Kerim GÜNEY; Bayram KIRAN; Mahmut GÜR; Ergin Murat ALTUNER; Talip ÇETER
    Aim of study: The aim of this study is to put forward the antimicrobial activity of cold pressed oils obtained from seeds of nettle (Urtica dioica), radish (Raphanus sativus) and pomegranate (Punica granatum).Material and Methods: Oils of these seeds were analysed for their antibacterial and antifungal activities by the disk diffusion and MIC tests against fifteen microorganisms, Staphylococcus epidermidis DSMZ 20044, Staphylococcus aureus ATCC 25923, Salmonella typhimurium SL 1344, Salmonella kentucky, Salmonella infantis, Salmonella enteritidis, Pseudomonas fluorescens P1 ATCC 13075, Pseudomonas aeruginosa DSMZ 50071, Klebsiella pneumoniae, Escherichia coli ATCC 25922, Enterococcus faecium, Enterococcus faecalis ATCC 29212, Enterobacter aerogenes ATCC 13048, Candida albicans DSMZ 1386 and Bacillus subtilis DSMZ 1971. The results were compared against 11 standard antibiotics, which are cefazolin, clindamycin, chloramphenicol, ciprofloxacin, amoxicillin/clavulanic acid, sulfamethoxazole/trimethoprim, ceftriaxone, gentamicin, ampicillin, cephalothin, cefuroxime and vancomycin. The extracts were also chemically analysed by using GC-MS.Main results: As a result, radish oil is observed to be active against all microorganisms with the highest activity, where nettle oil is active against all microorganisms except for S. epidermidis. The lowest activity was observed in pomegranate oil.Highlights: The results of the study clearly puts forward that oils obtained from nettle, radish and pomegranate could have a possible medicinal use.
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    The Structure-Activity Relationships of Familiar Antiepileptic Drugs and Na+ Channels
    (2022-06-30) Esra Nur ÇAKMAK; Mahmut GÜR; Bayram KIRAN
    The aim of this study is to examine the effects of drug active compounds, which are widely used in the treatment of epilepsy, on voltage-gated Na+ channels are important channels that advance the action potential in the excitation direction by molecular docking method. These molecules have been selected considering the physiopathological effect mechanisms of epilepsy disease. When the action potential is stimulated, Na+ channels allow sodium ion entry into the cell and cause epilepsy seizures. For this reason, PDB ID: 4PA6 receptor, which acts as an antagonist according to its activity on the canal in the formation of epileptic seizures, was chosen for molecular docking study. As a result of molecular docking studies; Phenytoin gave the best binding affinity for 4PA6 with a value of -7.7 kcal/mol. Other results in descending order (as kcal/mol); Mesuximide (-7.5), Remacemide (-7.3), Tiagabine (-7.1), Ethotoin and Mephenytoin (-7.0), Primidone (-6.9), Topiramate (-6.6), Oxcarbazepine and Lamotrigine (-6.3), Felbamate (-6.0), Lacosamide (-5.9), Zonisamide (-5.8), Levetirecetam and Gabapentin (-5.7), Ethosuximide (-5.6), Trimethadion (-5.1), Valproic Acid (-5.0), Vigabatrin (-4.0), determined as.