Browsing by Author "Basaran M.A."

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A B3LYP/DFT Study on the Structure Activity Relationship for Benzimidazole Derivatives in Water Solution
(2022-08-01) Al-Sawaff Z.H.; Basaran M.A.; Kandemirli F.
Abstract: In this article, a theoretical chemical study on 41 benzimidazole derivatives compounds used to treat osteoporosis was performed in water phase using density functional theory (DFT) based on the 6-311 basis set and B3LYP method as the level of theory to calculate energetic behavior and quantitative chemical descriptors such as energy gap between HOMO and LUMO, the total energy of different orbital transitions, chemical hardness, softness, electrophilicity index, and electronegativity. The results showed a noticeable difference between the compounds concerning chemical parameters due to substituting the active chemical molecules at the compounds’ R1, R2, R3, and R4 sites. The results showed that compound no. 3 could be considered the most exciting compound due to its unique values obtained. On the other hand, it was found an appropriate relationship between the quantitative arithmetic variables and the IC50 values for each compound. Statistical analysis between the compounds under test and a quantitative descriptor of the ten traits were included to produce two different prediction models based on artificial neural networks due to negative and positive IC50 values after data pre-processing.
ETM and ANN study for polysubstituted 2H-pyran-2-ones
(2013-09-01) Saracoglu M.; Basaran M.A.; Thul P.; Sayiner H.; Kandemirli S.G.; Gupta V.P.; Kandemirli F.
The structure glutamate pyruvate transaminase (GPT), glutamate oxaloacetate transaminase (GOT), acid phosphatase (ACP), alkaline phosphatase (ALP) and glutamate dehydrogenase (GlDH) activity relationships of 2H-pyran-2-ones polysubstitutes being a new class of hepatoprotective agents have been investigated by means of the Electronic-Topological Method (ETM) and two Statistical Analysis. Molecular fragments specific for active compounds were calculated for 2H-pyran-2-ones polysubstitutes by applying the ETM. QSAR descriptors such as molecular weight, EHOMO, ELUMO, ΔE, chemical potential, softness, electrophilicity index, dipole moment, etc were calculated. In order to examine the relationship between independent and dependent variables, both Partial Least Squares Regression and ANNs are employed to determine the relationship since the data set consists of highly nonlinearity and multicolinearity. It is observed that ANN has surpassed both PLS2 and PLS1 in terms of better modeling and validation. © 2013 Bentham Science Publishers.
The quantum chemical calculations of serine, therionine and glutamine
(2014-01-01) Kandemirli F.; Saracoglu M.; Amin M.A.; Basaran M.A.; Vurdu C.D.
An examination of quantum chemical and corrosion inhibition studies for three serine (Ser), therionine (Thr) and glutamine (Glu) which had been tested as corrosion safe inhibitors for cold rolled steel (CRS) in 1.0 M HCl solutions at different temperatures (283-333 K) were made to see if any clear links exist between them. The Genetic Function Approximation Method has been used for QSAR study. The correlation between inhibition efficiency and descriptor variables obtained from the quantum chemical calculation using B3LYP/6-311G(d,p), B3LYP/6-311++G(2d,2p), MP2/6-311G(d,p), and CBS-APNO methods. © 2014 The Authors.