Browsing by Author "Aydin S."

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Can Shear Wave Elastography Help Differentiate Acute Tonsillitis from Normal Tonsils in Pediatric Patients: A Prospective Preliminary Study
(2023-04-01) Ece B.; Aydin S.
Shear wave elastography (SWE) is a non-invasive imaging technique used to quantify the elasticity/stiffness of any tissue. There are normative SWE studies on tonsils in healthy children in the literature. The purpose of this study is to analyze the palatine tonsils in children with acute tonsillitis using ultrasound and SWE. In this prospective study, pediatric patients aged 4–18 years diagnosed with acute tonsillitis and healthy children were included. Those with antibiotic use, chronic tonsillitis, adenoid hypertrophy, and having chronic disease, immunodeficiency, and autoimmune disease, or any rheumatological disease were excluded. The volume and elasticity of palatine tonsil were measured via ultrasound and SWE. The study included 81 (46 female, 35 male) acute tonsillitis patients, and 63 (38 female, 25 male) healthy children between the ages of 4 and 18. Elasticity (kPa) values of tonsils were found significantly higher in the tonsillitis group (SWE-R: 25.39 ± 4.64, SWE-L: 25.01 ± 4.17) compared to the normal group (SWE-R: 9.71 ± 2.37, SWE-L: 9.39 ± 2.19) (p < 0.001). In the tonsillitis group, a significant positive correlation was found between tonsil volume and elasticity (r: 0.774, p: 0.002). In conclusion, in pediatric patients with acute tonsillitis, higher kPa values were obtained with SWE in the palatine tonsils.
Earthquakes from a radiological perspective: what is demanded from the radiologists, and what can we do? A pictorial review
(2024-01-08) Aydin S.; Kazci O.; Ece B.; Kantarci M.
Effect of dietary protein level on growth performance and nitrogen excretion of the juvenile convict cichlid, Amatitlania nigrofasciata
(2014-01-01) Gultepe N.; Acar U.; Kesbic O.; Gokkus K.; Aydin S.
A 8 weeks growth trial was conducted to determine the effects of dietary protein on the growth of the convict cichlid Amatitlania nigrofasciata and on water quality in closed recirculating systems. Four test diets were formulated to contain protein levels ranging 30-45%. The fish averaging 0.47±0.07 g were reared in 10 L aquarium. Fish were fed ad libitum at 08:30, 12:30 and 16:30 for 8 weeks. A second-order polynomial regression between dietary protein levels and weight gain in each group, demonstrated that the most suitable protein level for maximum growth was determined to be 40.8%. The feed conversion ratios of fish ranged from 1.78-2.78 in the experimental groups. Results showed significant differences in SGR and WG. Dietary protein level significantly influenced ammonia excretion, fish fed 45% protein excreted higher concentrations of ammonia-nitrogen than fish fed 30-40% dietary protein. For optimum growth, feed conversion and ammonia excretion, a diet containing 40.8% protein, 12% lipid and 20.8 kJ gross energy/kg diet is recommended for juvenile convict cichlids, A. nigrofasciata. © Medwell Journals, 2014.
Effect of Trachelobdella lubrica (Hirudinea: Piscicolidae) on biochemical and haematological characteristics of black scorpion fish (Scorpaena porcus, Linnaeus 1758)
(2006-10-01) Celik E.; Aydin S.
Black Scorpion fish (Scorpaena porcus Linnaeus 1758) caught during monthly sampling carried out in 2003 in the Dardanelles, Turkey, were examined for the parasite. Trachelobdella lubrica. Infested fish were caught only during December 2003, and the clinical conditions of the 12 fish naturally infested with T. lubrica included fin rot, swollen foci of skin and haemorrhages of the gill and abdominal skin. The prevalence, intensity and abundance of infestation in December 2003 were 40%, 1.75 and 0.70, respectively. The average hepatosomatic index of the infested fish was lower than that of noninfested fish, while the means of the kidney index, splenosomatic index, condition factor, body weight and length were not significantly different between the infested and noninfested fish groups. Blood analysis was conducted on 12 naturally infested and 12 healthy (noninfested) Black Scorpion fish to determine the possible characteristic changes in blood parameters of the fish in response to natural infestation with T. lubrica. Blood leucocyte counts, haematocrit levels, serum total protein, albumin phosphorus, urea, glucose, globulin, cholesterol and triglyceride concentrations in naturally infested Black Scorpion fish were significantly less than those of the noninfested fish (p < 0.05). No significant decreases were observed in the serum sodium, iron, calcium, potassium, chlorine, blood urea nitrogen and creatinine values of the naturally infested fish. Blood haemoglobin values, erythrocyte counts and serum glutamate aspartate aminotransferase (glutamate oxalacetate transaminase), alanine aminotransferase (glutamate pyruvate transaminase), uric acid and very low-density lipids levels of infested fish were insignificantly greater than those in healthy fish. © Springer Science+Business Media B.V. 2006.
Effect of zeolite and copper sulfate, administered alone and in combination on the biochemical components of blood serum of common carp, Cyprinus Carpio
(2016-01-01) Mutlu E.; Aydin S.; Demir T.; Yanik T.
Effects of zeolite have been described on the biochemical parameters of blood of Cyprinus carpio exposed to copper sulphate. The control fish showed 57.67% increase in body weight over a period of 90 days. This increase was 26.45% after exposure to copper sulphate (2mg/L) and 32.01% after Zeolite treatment (60 mg/L). When Zeolite was administered along with copper sulfate the fish showed 46.24% increase in body weight. Blood sampling were made for the determination of hematological values (glucose (GLU), blood urea nitrogen (BUN), total protein (TP), albumin (ALB), globulin (GLB), creatinine (CR), total bilirubin (TBIL), uric acid (UA), and direct bilirubin (DBIL)) at 30, 60, 90 days. Fish weight increased 26.45%, 46.29%, 32.01% and 57.67% respectively in groups and differences between groups were significant (p
Effects of herbs and spice on health status of tilapia (Oreochromis mossambicus) challenged with Streptococcus iniae
(2014-01-01) Gültepe N.; Bilen S.; Yilmaz S.; Güroy D.; Aydin S.
Effects of different herbal extracts on the growth and immune defense of fish were researched in the last decade. The aim of this study was to determine the dietary effects of thyme (Thymus vulgaris), rosemary (Rosmarinus officinalis) and fenugreek (Trigonella foenum graecum) as a feed additive on haematology, innate immune response, and disease resistance of tilapia (Oreochromis mossambicus). In total 228 healthy fish tilapia were divided into four groups (57 fish in one group) and fed diets supplemented with thyme, rosemary and fenugreek at levels of 1%, respectively; fish in the control group were fed diet without any spices. Fish were fed ad libitum three times a day for 45 days. All fish of the experimental groups significantly (P < 0.05) enhanced phagocytic activity, haematocrit, white blood cell, red blood cell, neutrophil and monocyte counts in blood. Significant (P < 0.05) increase of plasma myeloperoxidase and lysozyme activity was found in fish receiving a feed supplemented with fenugreek after 30 days. Respiratory burst activity was non-significantly (P > 0.05) changed during the whole experiment. After 45 days of feeding, fish were injected intraperitoneally with 100 μl of Streptococcus iniae (8 × 108 colony forming unit). The cumulative mortality was 22%, 27% and 31% in fish receiving diets supplemented with 1% thyme, rosemary and fenugreek, respectively, compared to 61% mortality in the control group. The results indicate that all three supplements used improved the haematological status, non-specific immune response and disease resistance of tilapia against S. iniae; this is the first similar study.
Evaluation of the Effect of Topical Prostaglandin Analog Treatment on Orbital Structures in Open-Angle Glaucoma with Computed Tomography
(2024-10-01) Durmuş Ece B.Ş.; Yozgat Z.; Bayramlı H.; Ece B.; Aydin S.
Gross pathology, blood chemistry, lipid and peroxide contents in rainbow trout (Oncorhynchus mykiss Walbaum) affected by experimental Arcobacter cryaerophilus infection at low water temperature
(2009-06-01) Aydin S.; Gure H.; Cakici H.; Colakoglu S.; Bircan R.
Arcobacter cryaerophilus was isolated from naturally infected rainbow trout ( Oncorhynchus mykiss Walbaum), and its pathogenicity was tested by intramuscular injection using healthy 1-year-old rainbow trout under cold-water conditions (at 5 °C). The lethal dosage of 50% end point (LD50) for A. cryaerophilus was calculated as 7.79 × 10 5 viable cells. Experimental infection caused gross clinical abnormalities such as fallen scales, exophthalmia, oedema in injection region and at the base of fins, pale gills, kidney necrosis, hyperaemic areas in pale liver, haemorrhagic spots in heart, elongated spleen and swollen gallbladder. Activities of aspartate aminotransferase and alkaline phosphatase, and concentrations of glucose, total protein, albumin, cholesterol, triglyceride and calcium in the serum of the experimentally infected rainbow trout were significantly decreased compared with the healthy fish. Positive correlations were observed among blood parameters. Total lipid weights increased in the brain, muscle and liver tissues of infected fish and dropped in the gill and spleen tissues. Lipid peroxide contents in the brain, liver, kidney, spleen, muscle and gill tissues of infected rainbow trout were significantly higher than in healthy animals. The present work shows that A. cryaerophilus can be moderately virulent for rainbow trout at low water temperature, and changes in lipid and lipid peroxide contents of tissues and blood indices can highlight barely detectable effects of A. cryaerophilus infection in rainbow trout under laboratory conditions. However, the application of these indices in farm biomonitoring using rainbow trout will need more detailed studies and a careful consideration of the environmental parameters. © 2009 Akadémiai Kiadó.
Individual and combined effects of CTLA4-CD28 variants and oxidant-antioxidant status on the development of colorectal cancer
(2015-10-01) Kucukhuseyin O.; Turan S.; Yanar K.; Arikan S.; Duzkoylu Y.; Aydin S.; Cakatay U.; Mezani B.; Farooqi A.A.; Aydinoʇlu Isitmangil G.; Kiran B.; Cacina C.; Nurdan Yenilmez E.; Ergen A.; Zeybek U.; Yaylim I.
Background: Colorectal cancer (CRC) is the third most frequent cancer worldwide. Research has revealed the contributions of the immune system and anti-inflammatory pathways in the development of cancer. The balance between cluster of differentiation 28 (CD28) and cytotoxic Tlymphocyte- associated protein 4 (CTLA4) signaling is important for the regulation of immune responses. The oxidant-antioxidant balance by sustaining redox control via several defense mechanisms is also an important factor for the progression of cancer. The aim of the present study was to determine the distribution of CTLA4/CD28 variants and oxidant-antioxidant status in patients with CRC. Materials and Methods: This study enrolled 80 patients with CRC and 115 healthy controls. We used a spectrophotometric assay to detect the levels of lipid peroxidation products malon dialdehyde (MDA) and lipid hydroperoxide (LHP), and measured the concentration of protein damage products, advanced oxidation protein products (AOPP) and protein carbonyl (PCO). Additionally, antioxidant levels were detected by measuring copper, zinc, superoxide dismutase (Zn-Cu SOD) and total thiol (T-SH) levels, and advanced glycation end-products (AGEs). The CTLA4 -318C>T, CTLA4 49A>G and CD28C>T genotypes were determined by using restriction enzymes. Results: AOPP and PCO levels were increased in patients with CRC as well as those of LHP, MDA and AGE, while the levels of antioxidants such as Cu-Zn SOD and T-SH were lower. Lower serum levels of CTLA4 and higher serum levels of CD28 were detected in patients and, an association of the CTLA4 -318C/T polymorphism was found in patients with CRC. Conclusion: Our oxidative stress was increased in patients with CRC, suggesting the contribution of this disturbed oxidative status to serum CTLA4 and CD28 levels, and to the pathogenesis of CRC.
Modulating effects of pycnogenol® on oxidative stress and DNA damage induced by sepsis in rats
(2014-01-01) Taner G.; Aydin S.; Bacanli M.; Sarigöl Z.; Sahin T.; Başaran A.; Başaran N.
The aim of this study was to evaluate the protective effects of Pycnogenol® (Pyc), a complex plant extract from the bark of French maritime pine, on oxidative stress parameters (superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities and total glutathione (GSH) and malondialdehyde (MDA) levels), an inflammatory cytokine (tumor necrosis factor alpha (TNF-a) level) and also DNA damage in Wistar albino rats. Rats were treated with 100 mg/kg intraperitonally Pyc following the induction of sepsis by cecal ligation and puncture. The decreases in MDA levels and increases in GSH levels, and SOD and GPx activities were observed in the livers and kidneys of Pyc-treated septic rats. Plasma TNF-a level was found to be decreased in the Pyc-treated septic rats. In the lymphocytes, kidney, and liver tissue cells of the sepsis-induced rats, Pyc treatment significantly decreased the DNA damage and oxidative base damage using standard alkaline assay and formamidopyrimidine DNA glycosylase-modified comet assay, respectively. In conclusion, Pyc treatment might have a role in the prevention of sepsis-induced oxidative damage not only by decreasing DNA damage but also increasing the antioxidant status and DNA repair capacity in rats.
Preliminary assessment of dietary mannanoligosaccharides on growth performance and health status of gilthead seabream Sparus auratus
(2012-09-13) Gültepe N.; Hisar O.; Salnur S.; Hoşsu B.; Tansel Tanrikul T.; Aydin S.
A feeding trial was performed to assess the potential beneficial effect of two levels of mannanoligosaccarides (MOS) on the growth performance, feed utilization, hematological parameters, and liver histopathology of gilthead seabream Sparus auratus (also known as gilthead bream). Mannanoligosaccarides were added at the rates of 2 and 4 g/kg to a fish-meal-based control diet, and each diet was given (twice daily [midmorning and midafternoon] to apparent satiation) to triplicate groups of gilthead seabream growers (mean weight = approximately 170 g) in sea cages. The trial lasted 12 weeks, and the average ambient water temperature ranged from 19.6°C to 24.7°C during the experimental period. At the end of the experiment, fish attained market size (350-450 g) and their health status was evaluated by blood analysis and liver histology. There were no differences in survival rates among fish fed experimental diets. However, there were significant improvements in both growth and feed utilization among fish fed diets supplemented with MOS. Hemoglobin (Hb) and hematocrit (Ht) levels and erythrocyte, leukocyte, and thrombocyte (Thr) counts were unaffected by any dietary MOS. The levels of Hb (g/dL; mean ± SD) and Ht (%; mean ± SD) were 11.0 ± 2.5 and 45.6 ± 6.7 for the control group, 11.1 ± 1.7 and 39.3 ± 8.0 for the 2-g/kg group, and 11.2 ± 1.9 and 40.2 ± 8.4 for the 4-g/kg group. Themean Thr count ranged from 47.6 to 53.8 × 103/mm3. Despite the apparently higher Thr counts for fish fed diets supplemented with MOS, these differences were not significant. Moreover, no histopathological differences were observed in liver tissue cross sections between control and treatment groups. These results suggest that supplementation of diets withMOS had no significant effects on general fish health. © American Fisheries Society 2011.
Pseudomonas elongata infection in scattered mirror carp (Cyprinus carpio): Bacteriology, gross pathology and treatment
(2009-11-11) Gültepe N.; Aydin S.
Pseudomonas elongata was isolated from naturally infected scattered mirror carp (Cyprinus carpio) and its pathogenicity was tested by intramuscular injection. The infection caused mortality in scattered mirror carp with gross clinical abnormalities such as dark coloured of a location on body surface, cataract in eyes, haemorrhagic damage of liver, irrigation in kidney, anemia, swollen intestine, fins rot and hyperaemia in operculum and skin. Lethal Dose50 (LD50) of Pseudomonas elongata was calculated 2.24×105. No significant difference was obtained among enumered of pathogenic bacteria isolated from gill, liver, kidney tissues and total pathogenic bacteria. Sensitivities of Pseudomonas elongata against 50 chemotherapeutants were tested. Minimum inhibitory concentrations of enrofloxacin and chloramme T to the isolate were calculated 5 mL L-1 and 10 mg L-1, respectively. Best treatment method was no mortality performed with orally enrofloxacin application and chloramme T bath. © Medwell Journals, 2009.
Quantitative Analysis of Supraspinatus Tendon Pathologies via T2/T2* Mapping Techniques with 1.5 T MRI
(2023-08-01) Ece B.; Yigit H.; Ergun E.; Koseoglu E.N.; Karavas E.; Aydin S.; Kosar P.N.
Shear Wave Elastography-Correlated Dose Modifying: Can We Reduce Corticosteroid Doses in Idiopathic Granulomatous Mastitis Treatment? Preliminary Results
(2023-03-01) Ece B.; Aydin S.; Kantarci M.
Idiopathic granulomatous mastitis (IGM) is a chronic inflammatory breast disease treated with local and systemic corticosteroids. This study aims to evaluate the efficacy of reducing corticosteroids doses in IGM cases based on shear wave elastography (SWE) tissue stiffness measurements. This prospective study included IGM patients who received systemic or local corticosteroids between January 2020 and September 2022. A 20% or more reduction in tissue elasticity values (kPa) was considered a positive response to treatment in the study group, and the corticosteroids dose was reduced. The control group was dosed routinely. All patients were followed for 2 years to compare treatment efficacy, duration, total corticosteroids dose, recurrence, and side effects. There were 12 patients (9 local/3 systemic corticosteroids) in the study group and 24 patients (17 local/7 systemic corticosteroids) in the control group. Ten (83.4%) out of 12 patients in the study group were successfully treated by reducing corticosteroid doses with follow-up, and 2 (16.6%) out of 12 patients were reverted to the initial treatment protocol due to an increase in elasticity values during the follow-up. Nevertheless, successful treatment results were obtained in these two patients without reducing the corticosteroid dose. When compared to the control group, the median corticosteroid dose in the study group was significantly lower in patients using both local (p < 0.01) and systemic (p < 0.01) corticosteroids. A significant negative correlation was found between the rate of decrease in elasticity values and the median dose of corticosteroids (r = −0.649, p < 0.05) and the median treatment time (r = −0.751, p < 0.01). Side effects due to corticosteroids were found to be significantly lower in the study group (p < 0.05). According to our first and preliminary results, the SWE-correlated dose-modifying technique may reduce corticosteroid doses and side effects without significantly compromising treatment efficacy.
Socio-Economic, Demographic and Health Determinants of the COVID-19 Outbreak
(2022-04-01) Ozyilmaz A.; Bayraktar Y.; Toprak M.; Isik E.; Guloglu T.; Aydin S.; Olgun M.F.; Younis M.
Objective: In this study, the effects of social and health indicators affecting the number of cases and deaths of the COVID-19 pandemic were examined. For the determinants of the number of cases and deaths, four models consisting of social and health indicators were created. Methods: In this quantitative research, 93 countries in the model were used to obtain determinants of the confirmed cases and determinants of the COVID-19 fatalities. Results: The results obtained from Model I, in which the number of cases was examined with social indicators, showed that the number of tourists, the population between the ages of 15 and 64, and institutionalization had a positive effect on the number of cases. The results obtained from the health indicators of the number of cases show that cigarette consumption affects the number of cases positively in the 50th quantile, the death rate under the age of five affects the number of cases negatively in all quantiles, and vaccination positively affects the number of cases in 25th and 75th quantile values. Findings from social indicators of the number of COVID-19 deaths show that life expectancy negatively affects the number of deaths in the 25th and 50th quantiles. The population over the age of 65 and CO2 positively affect the number of deaths at the 25th, 50th, and 75th quantiles. There is a non-linear relationship between the number of cases and the number of deaths at the 50th and 75th quantile values. An increase in the number of cases increases the number of deaths to the turning point; after the turning point, an increase in the number of cases decreases the death rate. Herd immunity has an important role in obtaining this finding. As a health indicator, it was seen that the number of cases positively affected the number of deaths in the 50th and 75th quantile values and the vaccination rate in the 25th and 75th quantile values. Diabetes affects the number of deaths positively in the 75th quantile. Conclusion: The population aged 15–64 has a strong impact on COVID-19 cases, but in COVID-19 deaths, life expectancy is a strong variable. On the other hand, it has been found that vaccination and the number of cases interaction term has an effect on the mortality rate. The number of cases has a non-linear effect on the number of deaths.
Sonographic findings of COVID-19 related acute scrotal infection and associations with clinical-laboratory data
(2022-11-01) Aydin S.; Tokur O.; Kazci O.; Ece B.; Karavas E.; Kantarci M.
Background: During the Coronavirus Disease 2019 (COVID-19) pandemic, patients present to hospitals with a wide range of symptoms. Some of these symptoms include acute orchitis and epididymitis. The goal of this research is to see if COVID-19 infection and scrotal infection are associated. Materials and methods: Patients with a COVID-19 (+) who agreed to a scrotal ultrasound (US) examination were studied prospectively in a tertiary care center between October 2021 and February 2022. The severity of the disease was used to divide patients into groups. Patients diagnosed with acute scrotal infection based on scrotal ultrasonography findings were compared in these groups, as were their age, comorbidities, and laboratory data. Results: The median age of the 213 participants was 61.7 ± 8.3. During the ultrasonographic examination of the patients, 15 (7%), 8 (3.7%), 17 (7.9%), and 40 (18.7%) were diagnosed with acute orchitis, acute epididymitis, acute epididymo-orchitis, and scrotal infection, respectively. Acute scrotal infection was far more common in patients with a higher clinical severity of the disease. The patients' comorbidities were also assessed, and it was discovered that they were statistically more common in the same group. Conclusions: Even if there are no clinical symptoms, ultrasonography can help detect acute scrotal infection in COVID-19 patients. Furthermore, in groups with higher clinical severity, this association is more likely to be seen. It is critical to understand this in order to avoid complications.
The Impact of Refugees on Income Inequality in Developing Countries by Using Quantile Regression, ANN, Fixed and Random Effect
(2022-08-01) Ozyilmaz A.; Bayraktar Y.; Isik E.; Toprak M.; Olgun M.F.; Aydin S.; Guloglu T.
Refugees affect the hosting countries both politically and economically, but the size of impact differs among these societies. While this effect emerges mostly in the form of cultural cohesion, security, and racist discourses in developed societies, it mostly stands out with its economic dimension such as unemployment, growth, and inflation in developing countries. Although different reflections exist in different societies, the reaction is expected to be higher if it affects social welfare negatively. Accordingly, one of the parameters that should be addressed is the effect of refugees on income distribution since the socio-economic impact is multifaceted. In this study, the effect of refugees on income inequality is analyzed by using quantile regression with fixed effects and Driscoll–Kraay Fixed Effect (FE)/Random Effect (RE) methods for the period of 1991 to 2020 in the 25 largest refugee-hosting developing countries. According to the findings of the study, the functional form of the relationship between refugees and income inequality in the countries is N-shaped. Accordingly, refugees first increase income inequality, decrease it after reaching a certain level, and then start increasing it, albeit at a low level.
The Relationship between Health Expenditures and Economic Growth in EU Countries: Empirical Evidence Using Panel Fourier Toda–Yamamoto Causality Test and Regression Models
(2022-11-01) Ozyilmaz A.; Bayraktar Y.; Isik E.; Toprak M.; Er M.B.; Besel F.; Aydin S.; Olgun M.F.; Collins S.
The aim of this study is to investigate the effect of health expenditures on economic growth in the period 2000–2019 in 27 European Union (EU) countries. First, the causality relationship between the variables was analyzed using the panel Fourier Toda–Yamamoto Causality test. The findings demonstrate a bidirectional causality relationship between health expenditures and economic growth on a panel basis. Secondly, the effects of health expenditures on economic growth were examined using the Random Forest Method for the panel and then for each country. According to the Random Forest Method, health expenditures positively affected economic growth, but on the country basis, the effect was different. Then, government health expenditures, private health expenditures, and out-of-pocket expenditures were used, and these three variables were ranked in order of importance in terms of their effects on growth using the Random Forest Method. Accordingly, government health expenditures were the most important variable for economic growth. Finally, Support Vector Regression, Gaussian Process Regression, and Decision Tree Regression models were designed for the simulation of the data used in this study, and the performances of the designed models were analyzed.