Browsing by Author "Alp, Ebru"

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    Pubmed
    Expression of , and long non‑coding RNAs in papillary thyroid cancer and its effects on clinicopathological features.
    (2022-04-01T00:00:00Z) Icduygu, Fadime Mutlu; Akgun, Egemen; Sengul, Demet; Ozgoz, Asuman; Alp, Ebru
    Long non‑coding RNAs (lncRNAs) are molecules that are >200 base pairs long and do not encode a protein. However, they perform important roles in regulating gene expression. Recent studies have revealed that the changes in the expressions of lncRNAs serve a role in the development and metastases of a number of types of cancer. A number of studies have been published on the association of SOX2 overlapping transcript (), differentiation antagonizing non‑protein coding RNA () and tissue differentiation‑induced non‑coding RNA () expression with various types of cancer. However, researchers have not yet studied their roles in papillary thyroid cancer or at least, those roles are not clarified. The aim of the present study was to investigate the expression and clinical significance of , and in papillary thyroid cancer (PTC). A total of 102 patients with PTC were included in the present study. Reverse transcription‑quantitative PCR method was used to determine the relative gene expression levels of lncRNAs and then the relationship between expressions of lncRNAs and clinical characteristics of the subjects was analyzed in detail. Expression levels of (P=0.016) and (P=0.017) increased in the tumor samples in contrast to the normal tissues. No significant difference was observed in the expression level of (P=0.298). In addition, expression was associated with micro carcinoma (P<0.001), tumor size (P=0.010) and primary tumor (P=0.006), while expression was associated with age (P=0.030) and micro carcinoma (P=0.004). The findings of the present study indicated that may contribute to the development of PTC while may contribute to both the development and progression of PTC.
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    Pubmed
    Upregulation and the clinical significance of KCNQ1OT1 and HAGLROS lncRNAs in papillary thyroid cancer: An observational study.
    (2023-07-21) Mutlu Icduygu, Fadime; Akgun, Egemen; Ozgoz, Asuman; Hekimler Ozturk, Kuyas; Sengul, Demet; Alp, Ebru
    Long noncoding RNAs (lncRNAs) play an important role in regulating gene expression. Changes in their expression have been associated with many types of cancer, including thyroid cancer. This study aimed to investigate how changes in the expression of potassium voltage-gated channel subfamily Q member 1 opposite strand/antisense transcript 1 (KCNQ1OT1) and HAGLR opposite strand lncRNA (HAGLROS) lncRNAs correlate with the development and clinicopathological characteristics of papillary thyroid cancer (PTC). Reverse transcription-quantitative polymerase chain reaction was used to investigate the expression of lncRNAs in both tumor and adjacent normal thyroid tissue samples of the patients. Expressions of KCNQ1OT1 and HAGLROS were upregulated in the patients tumor samples compared to the adjacent normal thyroid samples. KCNQ1OT1 expression was linked to microcarcinoma and gender, while HAGLROS expression was linked to microcarcinoma and tumor size. When only microcarcinoma samples were evaluated, KCNQ1OT1 expression was higher in tumor tissues compared to normal tissues; however, no significant difference was observed in HAGLROS expression. Our data suggests that high expressions of KCNQ1OT1 and HAGLROS might contribute to the development of PTC and disease progression, and both lncRNAs may be potential therapeutic targets in PTC patients.