Browsing by Author "Algul S."

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Assessing Effectiveness of anaerobic threshold and respiratory compensation point on fat and carbohydrate oxidations during exercise in sedentary males
(2020-12-21) Ugras S.; Algul S.; Ozcelik O.
Study Objectives: Anaerobic threshold (AT) and respiratory compensation point (RCP) are two important metabolic set points. We aimed to determine the effects of exercise intensity at AT and RCP on the balance of substrate oxidation rates. Methods: Eleven male participants performed an incremental exercise test to exhaustion on a cycle ergometer to estimate AT and RCP. Subsequently, we conducted three 30 minute constant load exercise tests at AT (WAT), RCP (WRCP) and 25% below AT (W
Effects of curcumin administration on nesfatin-1 levels in blood, brain and fat tissues of diabetic rats
(2021-01-01) Algul S.; Ozcelik O.; Oto G.; Sarikaya M.; Goceroglu R.T.; Embiyaoglu N.M.; Caf F.; Öner S.; Akcan A.G.
OBJECTIVE: We evaluated the efficacy of curcumin administration on blood glucose levels and its relationship with nesfatin-1 levels in blood brain and adipose tissue of streptozotocin-induced diabetic rats. MATERIALS AND METHODS: A total of 28 male rats were divided into four groups: control group, type 2 diabetes mellitus (DM) group, control plus curcumin group and type 2DM plus curcumin group. After fifteen days, blood samples were collected from sacrificed rats. Nesftain-1 levels were analysed from blood, brain, and fat tissues of rats in all groups. RESULTS: Nesfatin-1 level was found to be significantly lower in blood, brain and fat tissues of type 2 DM rats compared to the control group. A significant decrease in fasting blood glucose levels was observed in the curcumin administration group compared to type 2 DM group. Improvement of fasting blood glucose level was accompanied by improvement of nesfatin-1 levels in blood, brain, and fat tissues. CONCLUSIONS: As expected, curcumin administration caused significant improvement in fasting blood glucose levels. However, for the first time, we found marked improvements in nesfatin-1 levels in blood, brain, and fat tissues of type 2 DM rats. Thus, considering the crucial role of nesfatin-1 in regulation of glucose metabolism, it is logical to expect an interactive relationship between curcumin and nesfatin-1.
Effects of exercise on Ghrelin
(2021-10-07) Algul S.; Elcin S.; Ozcelik O.
Ghrelin, a gastric derived acylated peptide, was discovered in 1999 as a mediator of growth hormone secretiation. Since then, ghrelin has been found to significant impacts on many physiological functions of body systems. Ghrelin has a potential on appetite stimulation that influence on regulation of energy metabolism. It is known that exercise has a marked impact on energy homeostasis and consequently many research focused on the interaction between exercise stimulus and ghrelin response. This review provides an overwiew of research relating to the acute and chronic effects of exercise on (total, acyl and desacyl) ghrelin levels and also impact of exercise intensity on ghrelin levels. Although there is uncertainty among the results of previous studies, our review suggests that acute exercise transiently enterferes with the acly and total ghrelin levels. However, chronic exercise may acause increase in ghrelin levels in contrast to acute exercise with related to change of body weight. In adition, inenstiy of exercise may also reveales various results concerning the relationship between exercise and circulation ghreline levels. The discovery of ghrelin has raised our knowledge of food intake regulation, energy homeostasis and metabolic function mechanism. Further studies should be focused betwen the impact of exercise (type, duration and intensity) on circulation ghreline levels. Exercise induced ghrelin levels will likely generate new pharmacological approaches to many metabolic diseases based on inbalance in body energy homeostasis.
Evaluating the energy regulatory hormones of nesfatin-1, irisin, adropin and preptin in multiple sclerosis
(2022-12-01) Algul S.; Ozcelik O.
Background: Nesfatin-1, irisin, adropin and preptin were originally introduced as energy regulatory hormones. However, the results of studies revealed that these hormones may also have important roles in inflammation, immune function and neurological impairment. Multiple sclerosis (MS) is a chronic autoimmune disease, characterized by progressive inflammation, demyelination, and axonal loss in the central nervous system. We aimed to evaluate nesfatin-1, irisin, adropin and preptin hormones in patients with MS accompanied by inflammation and central nervous system dysfunction. Materials and methods: A total of 110 subjects (65 patients with relapsing-remitting MS and 45 healthy individuals as control group) were included in this study. Venous blood samples were collected between 7:30 a.m. and 9:00 a.m. Serum concentrations of all markers were measured by enzyme linked immunoassay methods. The unpaired t-test was used to investigate between-group differences. Results: The nesfatin-1, irisin, adropin and preptin levels were found to be significantly lower in the MS group compared to the control group (p < 0.05). Conclusion: In the present study, circulating nesfatin-1, irisin, adropin and preptin levels were decreased in patients with MS. However, the pathogenesis of MS and the underlying molecular mechanism of these hormones in MS have still not been elucidated. Further investigations with larger sample sizes and longer periods are required to obtain satisfactory information. In conclusion, the energy regulatory hormones of nesfatin-1, irisin, adropin and preptin may have potential for the development of new therapeutic targets for treatment of inflammatory diseases.
Investigation of irisin level in brucella patients
(2021-01-01) Algul S.; Senol F.F.; Ugras S.; Esmer F.; Kara M.; Ekici P.; Ozcelik O.
This study aimed to determine whether the changes in the metabolism of Brucella patients affect the irisin hormone. Also, it is aimed to investigate the relationships between other laboratory findings used in the diagnosis of brucellosis patients and the irisin hormone. 160 persons (80 brucellosis, 80 controls) were included in this study. Blood was drawn from the people participating in the study following their overnight fast. Irisin level was measured by ELISA method, CRP and sedimentation levels were measured using autoanalysers and commercial kits. It was determined that the irisin level of Brucella patients was statistically significantly higher than the control group (p <0.05). It was determined that there is a negative correlation between irisin level and CRP and sedimentation level in Brucella patients. In Brucella patients, the higher irisin level than the control group showed a negative correlation with CRP and sedimentation levels, which are infection diagnosis criteria; It suggests that the level of irisin can be considered as a supportive diagnostic marker in these patients. Further studies are needed to evaluate irisin hormone as a supportive diagnostic criterion.
Response of Some Trace Elements to Soccer Match Performed Different Times of Day in Young Sedentary Male
(2022-01-01) Baltacı S.B.; Bengu A.S.; Ozcelik O.; Algul S.
Objective: We aimed to examine effects of soccer match induced metabolic stress on levels of some trace elements. Materials and Methods: Fourteen sedentary male subjects randomly performed three indoor soccer matches (2 x 30 minute) in morning, afternoon and at night on different days. Venous blood samples were taken before and after match. Plasma malondialdehyde levels measured by High Performance Liquid Chromatography. Total antioxidant capacity and total oxidant capacity were estimated using a commercially available enzyme-linked immunosorbent assay kit. Plasma iron, copper and zinc levels was measured using an Atomic Absorption Spectrophotometer. Results: Significant increases were found in iron, malondialdehyde and total oxidant capacity in all matches (p<0.0001). Zinc decreased (p<0.0001) in morning but increases at night soccer a match (p<0.0001) which is opposite to copper. Conclusions:There was no significant correlation between increased stress parameters and trace element levels. However, time of soccer match causes opposite influence on levels of zinc and copper.
The outstanding beneficial roles of irisin disorders
(2022-02-16) Ilcın S.; Algul S.; Ozcelık O.
Depression is a widely observed psychiatric disorder that affects a quite large number of people all around the world. A major depressive disorder (MDD) is a multifactorial disease that IS associated with fluctuations in appetite, body weight, and energy situations in addition to serious mood problems. The aim of this review is to investigate a possible link between energy regulatory hormones of irisin and depressive disorders. Irisin is a hormone that plays a significant role in the regulation of lipid and glucose metabolism in skeletal muscle and adipose tissue. Irisin was also reported to play significant roles in the central nervous system. In the literature there are reports indicating a beneficial antidepressant role of irisin in MDD. It should be emphasised that the antidepressive effects of exercise could be the result of exercise-induced increased hormones of irisin.