Browsing by Author "Şen F."

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Biological synthesis of silver nanoparticles using Rheum ribes and evaluation of their anticarcinogenic and antimicrobial potential: A novel approach in phytonanotechnology
(2020-02-05) Aygün A.; Gülbağça F.; Nas M.S.; Alma M.H.; Çalımlı M.H.; Ustaoglu B.; Altunoglu Y.C.; Baloğlu M.C.; Cellat K.; Şen F.
This paper reports the anticarcinogenic and antimicrobial properties of silver nanoparticles (Ag NPs) obtained by green synthesis using the extract of Rheum ribes (R. ribes), a medicinal plant. For the synthesis of Ag NPs, the ethanolic extracts of R. ribes were used as a reducing as well as the stabilizing agent. For the characterization of Ag NPs, advanced analytical methods such as transmission electron microscopy (TEM), X-Ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), and UV–vis spectrophotometry were performed. The synthesized Ag NPs obtained from R. ribes were evaluated as a cytotoxic agent against MDA-MB-231 breast carcinoma cell line. The IC50 values of the nanoparticles were ranged from 165 to 99 μg/mL against MDA-MB 231 cell line for 24 h and 48 h, respectively. The results show that the use of Ag NPs at low concentrations show the toxic effect in the cancer cells. In addition, the results of experiments on gram-positive (Staphylococcus aureus (S. aureus), Methicillin-resistant Staphylococcus aureus (MRSA) and Bacillus subtilis (B. subtilis)) and gram-negative (Escherichia coli (E. coli)) bacteria showed that the Ag NPs had high antimicrobial activity. The results suggest that Ag NPs can be developed as potential anticancer and antibacterial agents.
Comprehensive natural radioactivity and pollution risk assessments of aquatic media and sediment in Lake Van (Türkiye)
(2023-01-01) Selçuk Zorer Ö.; Yıldız Yorgun N.; Özdemir Ö.F.; Öğün E.; Aydın H.; Atıcı A.A.; Aydın F.; Bora G.; Şen F.; Çavuş A.; Bozlar Pınaroğlu B.; Solmaz H.; Elp M.
This paper studies the radionuclide (137Cs, 226Ra, 232Th, 40K) activity concentrations and gross radioactivities in waters and sediments of Lake Van, which is the third largest closed lake (with no natural or artificial outlet) within the Earth. The physico-chemical parameters were measured and evaluated in the lake waters. The mean gross α activities in surface, middle and bottom waters are 0.04, 0.03 and 0.03 Bq/L, respectively, and in the same order, the mean gross β activities are 0.30, 0.23 and 0.33 Bq/L, respectively. In sediment samples, the mean activity concentrations were measured as 1.98 Bq/g for gross-α, 3.46 Bq/g for gross-β, 48.3 Bq/kg for 226Ra, 32.0 Bq/kg for 232Th, 540.1 Bq/kg for 40K and 25.9 Bq/kg for 137Cs. The radiation hazard parameters values based on the measured activities were calculated and Raeq values are lower than the world average value in all samples, while Dout and AED values are relatively high in some sediment samples.
Distribution of fish species in the Van Lake Basin
(2016-01-01) Elp M.; Atici A.A.; Şen F.; Duyar H.A.
This study was carried out to determine the fish species of Van Lake Basin between in 2008-2012. Van Lake Basin is a closed basin that shaped approximately 2.3 % of Turkey. Because of closed basin character, the differences indicated in species diversity. Basin is rich in endemic species diversity with plant and animal species. This richness were reflected to fish species. All of the fish species naturally occurring in the lake basin are consist of endemic species. Alburnus tarichi, Alburnus timarensis, Barbus ercisianus, Capoeta cosswigi and Oxynoemacheilus ercisianus exhibited a natural distribution. Cyprinus carpio, Carassius gibelio, Gambusia holbrooki and Aphanius mento were constituted population from various water sources. In addition, escaped from fish farm sorvaccinated to water resources Oncorhynchus mykiss was unable to create the population. Barbus ercisianus and Capoeta cosswigi shown to create hybrid fish species in Zilan and Deliçay. Cyprinus carpio and Carassius carassius shown to create hybrid fish species in Nazik Lake.
Drinking water quality properties of Ercis, Van-Turkey
(2016-01-01) Atici A.A.; Gültekin A.; Şen F.; Elp M.
In this study, microbiological, physical, and chemical characters of drinking water supplied from city of Ercis were analyzed. Temperature, turbidity, conductivity, dissolved oxygen, biological oxygen demand, chemical oxygen demand, calcium, magnesium, total hardness, total alkalinity, free chloride, carbonate, bicarbonate, nitrite, nitrate, ammonia, phosphorus, zinc, copper, nickel, cobalt, cyanide, fluoride, aluminum, iron, potassium, manganese, molybdenum, silicon and microbiological parameters were analyzed in the laboratory. The results were evaluated according to “Turkish Regulation of Surface Water Quality Management, Turkish Water Pollution Control Regulations, TS 266, Turkish Regulation on Water Intended for Human Consumption”.
Evaluation of biological activity of 5-fluoro-isatin thiosemicarbazone derivatives
(2020-06-01) Ramadan M.A.G.; Baloglu M.C.; Altunoglu Y.C.; Kandemirli F.; Burhan H.; Aygün A.; Sayiner H.S.; Ozyigit F.; Şen F.
Isatin based materials can exhibit a wide range of biological activities including antimicrobial, antiviral, antifungal, anthelmintic, antitumor, anti-HIV, anti-inflammatory, antidepressant, antioxidant, anticonvulsant, antitubercular, analgesic, and central nervous system depressant activities. In this study, four compounds containing 5-Fluoro-isatin thiosemicarbazone with methoxyphenyl or methoxyphenyl in different positions and zinc complexes were evaluated based on their biological activities. Compound 2 was the strongest compound affecting gramnegative bacteria compared to the other compounds. Also, this compound indicated better antimicrobial activity than positive control antibiotics. Besides, compound 3 was the only compound that inhibited the growth of Salmonella spp. such as Salmonella enteritidis ATCC 13076 and Salmonella typhimurium NRRLE 4463. 5-Fluoro-Isatin thiosemicarbazone and its derivatives also showed DNA protection property from moderate to good protections. Among them, compound 4 displayed the highest DNA binding affinity. These compounds possessed a capacity for utilization as drugs or drug additives based on their effects on bacteria strains and DNA binding affinity.