Browsing by Author "Şahin A."

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Association of b7-h4 gene polymorphisms in urothelial bladder cancer
(2017-01-01) Özgöz A.; Şamli M.; Dinçel D.; Şahin A.; İnce Ü.; Sağlican Y.; Balci F.; Şamli H.
Background/aim: We aimed to study polymorphisms of the B7-H4 gene in order to evaluate a possible association in urothelial carcinoma, as it is highly expressed in cancer tissues. Materials and methods: In this study B7-H4 gene rs10754339, rs10801935, and rs3738414 SNPs were studied by PCR-RFLP method in paraffin-embedded tumor specimens from 62 urothelial carcinoma patients and in a control group including 30 patients without bladder cancer. Results: We detected that the rs10754339 polymorphism was more frequent in the cancer patients when compared with the control group (P < 0.05). Only the rs3738414 polymorphism showed a statistically significant difference in frequency between pathologic diagnostic groups. Conclusion: The rs10754339 AA genotype distribution was found to have a higher frequency whereas the rs3738414 AG genotype distribution was lower in the bladder cancer group (P < 0.05). None of the genotype distributions showed a significant difference from the control group for the rs10801935 polymorphism. We conclude that B7-H4 has the potential to be a useful prognostic marker in urothelial carcinoma.
Association of change in body condition score with milk yield and reproduction traits of holstein cows
(2020-04-01) Kul E.; Şahin A.; Uğurlutepe E.; Soydaner M.
The aim of the study was to determine the effect of changes in body condition score (BSC) on milk yield and reproduction traits in early (30, 60 and 90 d), mid (120 and 150 d) and late lactation (210 and 270 d) in Holstein cows raised on a private dairy cattle farm in Kırşehir, Turkey. The data were obtained from 140 cows calved from November 2014 to November 2015. BSC groups were categorized as low, moderate and high in early lactation (<2.75, 2.75–3.00 and >3.00), mid-lactation (<3.00, 3.00–3.25 and >3.25) and late lactation (<3.25, 3.25–3.50 and >3.50). Cows with low and moderate BCS in early (BCS<2.75 and BCS=2.75-3.00), mid (BCS<3.00 and BCS=3.00–3.25) and late lactation (BCS<3.25 and BCS>3.50) had a higher daily milk yield (DMY), lactation milk yield (LMY) and 305-day milk yield (305-dMY) (P<0.05). Reproduction traits were also affected (P<0.05) by BCS in mid-lactation. In mid-lactation, the cows with low and moderate BCS had a shorter period of calving to the first service interval (CFSI) and lower number of services per conception (NSC) than that of the cows with high BCS (P<0.05). Both milk yield and reproduction traits were adversely affected by high BCS. It is suggested that BCS can be used as a reliable indicator in indirect selection programs for higher milk yield and reproductive performance in Holstein cows.
Estimation of genetic and phenotypic parameters for body condition score, milk yield and milk composition, and factors affecting related traits during the first 150 days of lactation in Holstein cows
(2022-01-01) Kul E.; Şahin A.; Uğurlutepe E.; Soydaner M.; Abaci S.H.
This study aimed to estimate the genetic and phenotypic parameters for BCS, milk yield and its composition in Holstein cows. The data were collected in the first 150 days in milk (DIM) of 317 Holstein cows calved between 2017 and 2018 raised at a pri-vate dairy cattle farm located in Kırşehir of Turkey. In this study, parity and DIM were included as fixed factors in the model. The cows were grouped according to their BCS: low (BCS≤2.50), moderate (BCS=2.75-3.00) and high (BCS≥3.25). The results showed that effects of parity and DIM on BCS, test-day milk yield (TDMY), solids-non-fat (SNF), protein content (PC), lactose (LACT), fat yield (FY) and protein yield (PY) were significantly important (P<0.05), whereas fat content (FC) was not. The highest TDMY, FY and PY were determined in cows with low BCS. FC, SNF, PC and LACT were the highest in cows with high BCS compared to those with low BCS and moderate BCS. The estimated heritability were 0.188, 0.301, 0.184, 0.197, 0.194, 0.223, 0.196 and 0.342 for BCS, TDMY, FC, SNF, PC, LACT, FY and PY, respectively. Repeatability for these traits was estimated to vary from 0.257 to 0.521. Genetic correlations between BCS and milk yield traits were generally low and ranged from-0.175 to 0.191. Low to moderate phenotypic correlations were also observed between BCS and milk yield traits (-0.234 to 0.217). Despite estimated low heritability and correlations during the early lactation period in our study, these results showed that cows with lower BCS had higher milk yield and lower milk contents, and selection programs including BCS will lead to slight improvements of milk yield traits in Holstein cows.
Surgical management of displaced adolescent tillaux fractures with the mini-open technique
(2021-01-01) Ayas M.S.; Köse A.; Terzi E.; Dincer R.; Topal M.; Uymur E.Y.; Şahin A.
BACKGROUND: There is no consensus on the optimal treatment of Tillaux-Chaput fractures. The results of our cases treated with mini-open surgery (open reduction and internal fixation) concerning efficacy and complications, we aim to compare other procedures (open, percutaneous, and arthroscopy-assisted) with the literature data and to look for an answer to the question of whether the primary treatment can be mini-open surgery. METHODS: Between the years 2014 and 2017, 22 of 30 patients with Tillaux-Chaput fractures were treated using mini-open sur-gery, open reduction and internal fixation with one cannulated screw. These cases were retrospectively examined concerning age, sex, side, surgery duration, complications, and American Orthopedic Foot and Ankle Score (AOFAS). Functional results were statistically evaluated 12 months after the injury. Follow-up included a clinical examination, imaging and AOFAS. RESULTS: Of the patients, 14 were male (63.6%) and eight were female (36.4%). The mean age of the patients was 13.8 years. The mean surgery duration was 21 minutes. All fractures healed after an average of 14 weeks. No complications were observed in any of the cases. The mean follow-up time was 24.7 months. The mean preoperative AOFAS score was 53.3 and the mean postoperative AOFAS score was 93.6, which was a statistically significant difference. At the last follow-up, the AOFAS score was perfect for all cases. CONCLUSION: Contrary to what is stated in the literature, the mini-open surgical procedure has many advantages. The operation is very short and the risk of nerve injury is very low. This study showed that Tillaux-Chaput fractures could be safely and efficiently treated with mini-open surgery. We recommend mini-open surgery, complete anatomical reduction, and internal fixation for successful results.