Browsing by Author "Şahin Ö.F."

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Evaluation of subclinical alterations in retinal layers and microvascular structures with OCT and OCTA in healthy young short-term smokers
(2021-12-01) Işik M.U.; Akay F.; Akmaz B.; Güven Y.Z.; Şahin Ö.F.
Purpose: To detect the changes that can be determined with optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) in young and short-term smokers. Method: In this cross-sectional, observational, and comparative study, 45 "healthy" smokers and 45 healthy non-smoker control participants were included. Those with a smoking history between 1 year to 5 years and an average of 10–30 cigarettes per day were included in the study. OCT and OCTA measurements were made at least 60 min after smoking and at least 8 h after caffeine-containing beverages in order to end the effect of nicotine on systemic and retinal blood flow in the smoking group. Results: The mean smoking period was 2.2 ± 0.13 years. Mean macular thickness(MMT), retinal nerve fiber layer(RNFL), and choroidal thickness(Cht) were significantly lower in the smoker group, while ganglion cell-inner plexiform layer(GC-IPL) thickness was higher. Vessel density(VD) values were similar between groups, while perfusion density(PD) values were significantly higher in the smoker group. There were significant correlations between MMT and outer VD, outer PD, foveal avascular zone(FAZ) perimeter and circularity index. FAZ area and central VD and PD were inversely correlated. Also, FAZ circularity index and subfoveal, nasal, and temporal ChTs were positively correlated. Conclusion: Despite the short-term smoking, ischemic effects were observed in retinochoroidal and vascular structures.
The Relationship between Pupillometric Values and Visual Evoked Potential Test Results in Patients with Early Glaucoma
(2020-10-01) Işik M.U.; Şahin Ö.F.
SIGNIFICANCE Measuring pupil diameter may provide an additional objective method to detect and monitor glaucoma. PURPOSE The purposes of this study were to evaluate whether pupillometry can be used in the assessment of glaucomatous damage and to determine whether pupillometer can be used in glaucoma screening. METHODS In this retrospective study, patients with early stages of glaucomatous optic neuropathy were tested using visual evoked potential (VEP), standard automated perimetry, and pupillometer. The VEP record was made using two consecutive check sizes (1° and 15′) at 1-Hz frequency. Patients with a mean deviation of <-2 and >-6 dB were included in the study. Pupil size measurements were performed under photopic conditions at 60-, 100-, and 130-cd/m2 luminance levels with the OPD Scan (Nidek, Gamagori, Japan) device. RESULTS In all, 24 eyes of 24 patients (14 women and 10 men) with newly diagnosed open-angle glaucoma were included, and 30 eyes of 30 healthy subjects (15 women, 15 men) were used as controls. There was no significant difference between sexes in photopic pupil diameters in either group. Comparing the pupil diameters in different luminance levels, the diameters were significantly larger in the patient group. When age-corrected values in the glaucoma group were compared with an age-matched control group, the differences in P100 latency and amplitudes were statistically significant. There were significant correlations between photopic pupil diameters and timing of VEP waveforms. CONCLUSIONS There is a relationship between pupil diameters and VEP results in eyes with early glaucoma.