Browsing by Author "Özcan E."

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Biomedical Applications of Bisphosphonate Chelating Agents by Metal Cations as Drug Design for Prevention and Treatment of Osteoporosis using QM/MM Method
(2023-08-15) Mollaamin F.; Özcan S.; Özcan E.; Monajjemi M.
By investigating their pharmacological activity, bisphosphonate drugs can be employed to prevent the loss of one density and treat bone diseases like osteoporosis. The capability of bisphosphonates is to be stuck and be kept within bone during osteoclast-mediated bone inorganic material decomposition. The main problem accompanied by their application is their low oral bioavailability. Several delivery systems, such as metal chelating, nanoparticles, and contrast agents, have been selected to modify their absorption and to conduct them to sites other than bone cells. In this contribution, we have investigated the pharmacological and clinical application of bisphosphonate drugs of 5AFX, 4QPF, 3DYG, 2I19, and 2F92 using novel QM/MM applications of DFT, MC, and MD due to physicochemical properties of NMR, charge transfer, Gibbs free energy, electronic-kinetic and nuclear repulse energies in the pharmaceutical and biomedical fields. The bisphosphonate agent has been accomplished in chelation with the metal cation of Mg2+ and Cu2+ through the PDB structures of 5AFX, 4QPF, 3DYG, 2I19, and 2F92 drugs. Since the metal binding of phosphonate groups is relatively bulky, with six oxygens having a negative charge more than pH= 4, which is high (approximately four per ligand), these structures are active in forming the chelated compounds through the drug design method. The connection between structure and activity methods play an important role in predicting the biological properties of target compounds and their physicochemical properties. In this article, Ramachandran plot in drug design has played an efficient function in target identification and designing novel drugs for exploring the parameters of amino acid sequence, molecular modeling, and the 3-D structure bisphosphonate agents of novel drugs of 5AFX, 4QPF, 3DYG, 2I19, and 2F92.
Examining engaged couples’ opinions and attitudes towards fertility awareness, family planning and parenting in terms of gender
(2022-01-01) Özcan E.; Topatan S.
Being a parent that is part of the social life of individuals and getting married should be evaluated together with fertility to improve the health of society. Because individuals who are unaware of fertility may tend to make wrong decisions about how to manage their reproductive abilities. This study was conducted to determine by gender difference the fertility awareness of engaged couples and their attitudes toward parenthood and family planning. This cross-sectional study included 504 people who had decided to marry. In this study, a male/female questionnaire developed by the researcher and the Family Planning Attitudes Scale were used. When the couples evaluated the importance of having children to them on a scale from 0 to 10, no statistically significant differences by gender could be found (p =.589). Among the criteria for having children, the rate of agreement with the condition of having sufficient economic strength was higher among women than men (p =.031). The rate of agreement with the conditions of reaching a certain level of expertise in one’s occupation (p =.014) and living in a big enough house (p =.040) was higher among men than women. The Family Planning Attitudes Scale total mean score was 112.5 for the male participants and 117.0 for the female participants (p =.004). The scale evaluates the family planning attitude as positive and negative. Higher scores indicate more positive attitudes toward family planning. It was determined that couples’ were at a similar level of fertility awareness and women had a more positive family planning attitude than men. There were differences by gender in couples’ views on parenting.
The effect of fear of contagion/being contagious on depression, anxiety and stress levels of university students during the COVID-19 pandemic
(2022-01-01) Iskender M.D.; Gülsoy A.; Özcan E.; Uyan Y.
Background: University students are generally quite active in social life. It is thought that their fear of contagion/being contagious will affect their depression, anxiety and stress levels due to the removal of restrictions and the increase in individual responsibilities. This study aims to determine the effect of fear of contagion/being contagious on depression, anxiety and stress levels of university students during the COVID-19 pandemic. Methods: This study, descriptive and cross-sectional. Quantitative data were collected using the Demographic Information Form, the Fear of Contagion/Transmission Scale and the Depression-Anxiety-Stress Scale. The sample included 3500 participants. Descriptive statistics were used for the presentation of the results. The STROBE checklist for cross-sectional studies was used in this study. Results: This study revealed that the depression, anxiety and stress levels of university students were above normal, and these results were mostly associated with females, those with a chronic disease and high fear of contagion/being contagious. Conclusion: The findings of this study may be useful for precautionary plans to support the psychological health of university students after the COVID-19 pandemic and in the fight against possible new pandemics. Considering the findings of our study, educational programs should be planned for youth in general and university students in particular to deal with depression, anxiety, stress and fears. Relevance to Clinical Practice: The depression, anxiety and stress levels of university students were above normal. As the fear of contamination and contagion increases, the level of depression, anxiety and stress increases. Those with chronic diseases have high levels of depression, anxiety and stress. Patient or Public Contribution: Research data were collected through an online questionnaire. Data collection tools were prepared on Google Forms, and then, links were shared with student groups over social media. Students shared the link on their social platforms, allowing it to reach wider audiences.