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Effects of Greek juniper (Juniperus excelsa) extract on immune responses and disease resistance against Yersinia ruckeri in rainbow trout (Oncorhynchus mykiss)

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dc.contributor.authorBilen, Soner
dc.contributor.authorIspir, Selcuk
dc.contributor.authorKenanoglu, Osman Nezih
dc.contributor.authorTaştan, Yiğit
dc.contributor.authorGüney, Kerim
dc.contributor.authorTerzi, Ertugrul
dc.date.accessioned2026-01-04T14:40:04Z
dc.date.issued2020-10-31
dc.description.abstractAbstractThis study investigated the effects of Greek juniper extract on immune responses of rainbow trout. In this experiment, 4 doses [0 (Control), 1 (J1), 4 (J4) and 8 (J8) mg/kg] of the extract were administered orally using an oral gavage twice a day for 14 days. Immune responses were measured on 7th and 14th days. On 14th day, Yersinia ruckeri was injected intraperitoneally to all fish of all groups. On 14th day, ORP in fish of J1 group increased significantly. Lysozyme activity (LA) was increased in J8 group on 7th day (p < .05). On 14th day, a significant decrease was determined in J1 and J4 treatments in LA. Myeloperoxidase activity was significantly decreased in all groups irrespective of sampling times (p < .05). Interleukin (IL)‐1β was significantly elevated in fish of J8 group on 7th day. IL‐8 increased in fish of J8 and J4 groups on 7th day of the study. IL‐12 gene expression was significantly up‐regulated in J8 fish group on 7th day, and in J4 fish group on 14th day. Survival rate was higher in J8 treatment compared to the control and other treatments (p < .05). The results suggest that Juniperus excelsa provides protection against Y. ruckeri in rainbow trout.
dc.description.urihttps://doi.org/10.1111/jfd.13293
dc.description.urihttps://pubmed.ncbi.nlm.nih.gov/33128804
dc.description.urihttps://dx.doi.org/10.1111/jfd.13293
dc.identifier.doi10.1111/jfd.13293
dc.identifier.eissn1365-2761
dc.identifier.endpage738
dc.identifier.issn0140-7775
dc.identifier.openairedoi_dedup___::6fb431f239fa7c5d8c1f98fd17d5c31b
dc.identifier.orcid0000-0001-9459-8178
dc.identifier.orcid0000-0002-6782-1597
dc.identifier.orcid0000-0003-2305-790x
dc.identifier.orcid0000-0003-2811-6497
dc.identifier.pubmed33128804
dc.identifier.scopus2-s2.0-85094673994
dc.identifier.startpage729
dc.identifier.urihttps://hdl.handle.net/20.500.12597/38332
dc.identifier.volume44
dc.identifier.wos000582983100001
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofJournal of Fish Diseases
dc.rightsCLOSED
dc.subjectYersinia ruckeri
dc.subjectYersinia Infections
dc.subjectPlant Extracts
dc.subjectImmunity, Innate
dc.subjectFish Diseases
dc.subjectAdjuvants, Immunologic
dc.subjectJuniperus
dc.subjectOncorhynchus mykiss
dc.subjectAnimals
dc.subjectDisease Resistance
dc.subject.sdg3. Good health
dc.titleEffects of Greek juniper (Juniperus excelsa) extract on immune responses and disease resistance against Yersinia ruckeri in rainbow trout (Oncorhynchus mykiss)
dc.typeArticle
dspace.entity.typePublication
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In this experiment, 4 doses [0 (Control), 1 (J1), 4 (J4) and 8 (J8) mg/kg] of the extract were administered orally using an oral gavage twice a day for 14 days. Immune responses were measured on 7th and 14th days. On 14th day, <jats:italic>Yersinia ruckeri</jats:italic> was injected intraperitoneally to all fish of all groups. On 14th day, ORP in fish of J1 group increased significantly. Lysozyme activity (LA) was increased in J8 group on 7th day (<jats:italic>p</jats:italic> &lt; .05). On 14th day, a significant decrease was determined in J1 and J4 treatments in LA. Myeloperoxidase activity was significantly decreased in all groups irrespective of sampling times (<jats:italic>p</jats:italic> &lt; .05). Interleukin (IL)‐1β was significantly elevated in fish of J8 group on 7th day. IL‐8 increased in fish of J8 and J4 groups on 7th day of the study. IL‐12 gene expression was significantly up‐regulated in J8 fish group on 7th day, and in J4 fish group on 14th day. Survival rate was higher in J8 treatment compared to the control and other treatments (<jats:italic>p</jats:italic> &lt; .05). The results suggest that <jats:italic>Juniperus excelsa</jats:italic> provides protection against <jats:italic>Y. ruckeri</jats:italic> in rainbow trout.</jats:p>"],"publicationDate":"2020-10-31","publisher":"Wiley","embargoEndDate":null,"sources":["Crossref"],"formats":null,"contributors":null,"coverages":null,"bestAccessRight":{"code":"c_14cb","label":"CLOSED","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/"},"container":{"name":"Journal of Fish Diseases","issnPrinted":"0140-7775","issnOnline":"1365-2761","issnLinking":null,"ep":"738","iss":null,"sp":"729","vol":"44","edition":null,"conferencePlace":null,"conferenceDate":null},"documentationUrls":null,"codeRepositoryUrl":null,"programmingLanguage":null,"contactPeople":null,"contactGroups":null,"tools":null,"size":null,"version":null,"geoLocations":null,"id":"doi_dedup___::6fb431f239fa7c5d8c1f98fd17d5c31b","originalIds":["10.1111/jfd.13293","50|doiboost____|6fb431f239fa7c5d8c1f98fd17d5c31b","33128804","3097126140"],"pids":[{"scheme":"doi","value":"10.1111/jfd.13293"},{"scheme":"pmid","value":"33128804"}],"dateOfCollection":null,"lastUpdateTimeStamp":null,"indicators":{"citationImpact":{"citationCount":23,"influence":3.0348584e-9,"popularity":1.8763085e-8,"impulse":17,"citationClass":"C4","influenceClass":"C5","impulseClass":"C4","popularityClass":"C4"}},"instances":[{"pids":[{"scheme":"doi","value":"10.1111/jfd.13293"}],"license":"Wiley Online Library User Agreement","type":"Article","urls":["https://doi.org/10.1111/jfd.13293"],"publicationDate":"2020-10-31","refereed":"peerReviewed"},{"pids":[{"scheme":"pmid","value":"33128804"}],"alternateIdentifiers":[{"scheme":"doi","value":"10.1111/jfd.13293"}],"type":"Article","urls":["https://pubmed.ncbi.nlm.nih.gov/33128804"],"publicationDate":"2021-05-26","refereed":"nonPeerReviewed"},{"alternateIdentifiers":[{"scheme":"mag_id","value":"3097126140"},{"scheme":"doi","value":"10.1111/jfd.13293"}],"type":"Article","urls":["https://dx.doi.org/10.1111/jfd.13293"],"refereed":"nonPeerReviewed"}],"isGreen":false,"isInDiamondJournal":false}
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