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A new pollen-derived microcarrier for pantoprazole delivery

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dc.contributor.authorAkyüz, Lalehan
dc.contributor.authorSargın, İdris
dc.contributor.authorKaya, Murat
dc.contributor.authorCeter, Talip
dc.contributor.authorAkata, Ilgaz
dc.date.accessioned2026-01-02T23:58:08Z
dc.date.issued2017-02-01
dc.description.abstractPlant-derived carriers have emerged as promising materials for drug encapsulation. Especially, sporopollenin microcapsules extracted from diverse pollen species have been proved to be effective drug carriers due to their biocompatibility, homogeneity in size, resistance to harsh chemical conditions and high thermal stability. Here in this study, sporopollenin microcapsules were isolated successfully from the pollens of a common tree (Corylus avellana, the European hazelnut) and used as a carrier for pantoprazole (PaNa) (a proton pump inhibitor). The drug entrapment efficiency was recorded as 29.81%. SEM micrographs clearly showed the drug was loaded into the microcapsules through the apertures of microcapsule and also some drugs were adsorbed on the surface of microcapsules. FT-IR spectra analysis confirmed the drug loading. Thermogravimetric analysis revealed that thermal stability of PaNa was enhanced by encapsulation. In vitro release studies showed that PaNa-loaded sporopollenin microcapsules exhibited better release performance than the control. C. avellana sporopollenin microcapsules can make an efficient carrier for delivery of PaNa.
dc.description.urihttps://doi.org/10.1016/j.msec.2016.11.009
dc.description.urihttps://pubmed.ncbi.nlm.nih.gov/27987792
dc.description.urihttps://dx.doi.org/10.1016/j.msec.2016.11.009
dc.description.urihttps://hdl.handle.net/20.500.12451/5883
dc.identifier.doi10.1016/j.msec.2016.11.009
dc.identifier.endpage942
dc.identifier.issn0928-4931
dc.identifier.openairedoi_dedup___::0cafbd3ebb16955bbf148d8b0979163d
dc.identifier.orcid0000-0001-8548-3037
dc.identifier.orcid0000-0003-3785-9575
dc.identifier.orcid0000-0001-6954-2703
dc.identifier.orcid0000-0003-3626-1758
dc.identifier.orcid0000-0002-1731-1302
dc.identifier.pubmed27987792
dc.identifier.scopus2-s2.0-85006085619
dc.identifier.startpage937
dc.identifier.urihttps://hdl.handle.net/20.500.12597/36389
dc.identifier.volume71
dc.identifier.wos000390967200109
dc.language.isoeng
dc.publisherElsevier BV
dc.relation.ispartofMaterials Science and Engineering: C
dc.rightsCLOSED
dc.subjectDrug Carriers
dc.subjectProton Pump İnhibitor
dc.subjectColon Delivery
dc.subjectPyridinylmethylsulfinylbenzimidazoles
dc.subjectKinetics
dc.subjectCorylus
dc.subjectHazelnut Pollen
dc.subjectDelayed-Release
dc.subjectPollen
dc.subjectPantoprazole
dc.titleA new pollen-derived microcarrier for pantoprazole delivery
dc.typeArticle
dspace.entity.typePublication
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