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Effect of tocilizumab on acinetobacter baumannii lung infection in an immunosuppressed rat model

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dc.contributor.authorCelebi, Demet
dc.contributor.authorHalici, Zekai
dc.contributor.authorCelebi, Ozgur
dc.contributor.authorAkgun, Nurullah
dc.contributor.authorCinar, Irfan
dc.contributor.authorHalici, Iclal
dc.contributor.authorCinisli, Kagan Tolga
dc.contributor.authorYildirim, Serkan
dc.date.accessioned2026-01-04T15:59:04Z
dc.date.issued2021-12-01
dc.description.abstractOur study aimed to investigate effect of tocilizumab on the lung tissue in the presence of Acinetobacter baumannii infection in immunosuppressed rats. A forty-eight female Wistar albino rats were divided equally into eight groups: Group 1: Healthy (H), Group 2: Immunosuppressed (IM), Group 3: Healthy rats given A. baumannii bacteria (H+BAC), Group 4: Immunosuppressed rats given A. baumannii bacteria (IM+BAC), Group 5: Healthy rats given tocilizumab (H+TCZ), Group 6: Immunosuppressed rats given tocilizumab (IM+TCZ), Group 7: Healthy rats given A. baumannii bacteria and tocilizumab (H+BAC+TCZ), Group 8: Immunosuppressed rats given tocilizumab and A. baumannii bacteria (IM+BAC+TCZ). Fourteen days after the immunosuppression of group 2, 4, 6 and 8 with hydrocortisone, group 3, 4, 7 and 8 were A. baumannii was dropped into the trachea. One hour after A. baumannii application, TCZ was administered to Groups 5, 6, 7 and 8. NF-κB, IL-6 and NLRP3 mRNA expressions were decreased in the IM group compared to the healthy group (P<0.05). Although NF-κB, IL-6 and NLRP3 mRNA expression decreased in the IM+TCZ group compared to the healthy group (P<0.05) NF-κB, IL-6 and NLRP3 mRNA expression increased in the H+TCZ group (P<0.05). Despite decreasing cytokines, A. baumannii has been shown to increase infection-related lung injury. This suggests that in patients currently or recently using steroids, tocilizumab may increase organ damage due to opportunistic infection.
dc.description.urihttps://doaj.org/article/bd2341034d944accb78759d620d4b36b
dc.identifier.issn1309-2251
dc.identifier.openairedoajarticles::efc10e18120f758529ff47d0a19d7969
dc.identifier.urihttps://hdl.handle.net/20.500.12597/39196
dc.language.isoeng
dc.publisherKafkas University, Faculty of Veterinary Medicine
dc.relation.ispartofKafkas Universitesi Veteriner Fakültesi Dergisi
dc.rightsOPEN
dc.subjecttocilizumab
dc.subjectVeterinary medicine
dc.subjectSF600-1100
dc.subjectimmunosuppressed rat
dc.subjectacinetobacter baumannii
dc.subject.sdg3. Good health
dc.titleEffect of tocilizumab on acinetobacter baumannii lung infection in an immunosuppressed rat model
dc.typeArticle
dspace.entity.typePublication
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