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Dose related inhibitor effect of enrofloxacin on in vitro feline spontaneous myometrial contractility

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dc.contributor.authorDogan, Halef
dc.contributor.authorOcal, Halis
dc.contributor.authorSafak, Tarik
dc.contributor.authorKilinc, Mehmet Akif
dc.contributor.authorRisvanli, Ali
dc.date.accessioned2026-01-04T16:40:39Z
dc.date.issued2022-04-01
dc.description.abstractEnrofloxacin is one of the most widely used antibacterial drugs in feline medicine. This study investigated the effects of enrofloxacin on in vitro feline spontaneous myometrial contractility at different sexual stages. Uterine samples of the 20 queen cats at different sexual periods were placed in a tissue bath, and in vitro spontaneous stretch-induced myometrial contractions were recorded for 10 min. The tissue bath was adjusted for cumulative enrofloxacin concentrations of 0.25 mM, 0.50 mM, 1.00 mM, and 2.00 mM, respectively. Myometrial contractions were recorded for 10 min after each dose was adjusted in the tissue bath. It was observed that enrofloxacin caused a significant decrease in the peak amplitude and area under curve, while causing an increase the frequency of stretch-induced myometrial contractions in a dose dependent manner in vitro at all sexual stages. The current preliminary study concluded that enrofloxacin has an inhibitory effect on in vitro feline uterine myometrial activity at all sexual stages. It is recommended to take this medical effect into consideration and apply enrofloxacin and uterotonics together in treatment of uterine infections in feline medicine.
dc.description.urihttps://doi.org/10.1016/j.anireprosci.2022.106972
dc.description.urihttps://pubmed.ncbi.nlm.nih.gov/35390740
dc.identifier.doi10.1016/j.anireprosci.2022.106972
dc.identifier.issn0378-4320
dc.identifier.openairedoi_dedup___::0eae88bd348f5813a3afed63d72ef9ef
dc.identifier.orcid0000-0003-1365-1729
dc.identifier.orcid0000-0002-6178-4641
dc.identifier.orcid0000-0003-1577-1556
dc.identifier.pubmed35390740
dc.identifier.scopus2-s2.0-85127308733
dc.identifier.startpage106972
dc.identifier.urihttps://hdl.handle.net/20.500.12597/39602
dc.identifier.volume239
dc.identifier.wos000821485400001
dc.language.isoeng
dc.publisherElsevier BV
dc.relation.ispartofAnimal Reproduction Science
dc.rightsCLOSED
dc.subjectEnrofloxacin
dc.subjectUterine Contraction
dc.subjectDose-Response Relationship, Drug
dc.subjectUterus
dc.subjectCats
dc.subjectMyometrium
dc.subjectAnimals
dc.subjectFemale
dc.subject.sdg3. Good health
dc.titleDose related inhibitor effect of enrofloxacin on in vitro feline spontaneous myometrial contractility
dc.typeArticle
dspace.entity.typePublication
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