Yayın:
BIOCHEMICAL AND PATHOLOGICAL EFFECTS ON THE MALE RAT HEPATIC TISSUE AFTER EXPOSURE TO 900MHZ ELECTROMAGNETIC FIELD DURING ADOLESCENT PERIOD

Basit Görünüm
dc.contributor.authorİKİNCİ KELEŞ, Ayşe
dc.contributor.authorEROL, Hüseyin Serkan
dc.contributor.authorSAPMAZ, Tuğçe
dc.contributor.authorMERCANTEPE, Tolga
dc.contributor.authorKELEŞ, Gökhan
dc.contributor.authorBİTERGE SÜT, Burcu
dc.contributor.authorODACİ, Ersan
dc.contributor.authorHALICI, Mesut
dc.contributor.authorPOLAT, Sait
dc.date.accessioned2026-01-04T15:30:58Z
dc.date.issued2021-06-30
dc.description.abstractThe aim of this study was to employ biochemical analysis and histopathological techniques to investigate the effects of the application of a 900-megahertz electromagnetic field during adolescence on the rat liver. 24 male Sprague Dawley rats aged 21 days were randomly divided into electromagnetic field, sham and control groups. No procedure was performed on the control group rats. Electromagnetic field group rats were exposed to a 900-megahertz electromagnetic field in an electromagnetic field application cage (1 hours/day, every day for 25 days). The sham group rats were placed in the same electromagnetic field cage without exposure to electromagnetic field. At the end of the experiments, the livers were removed. The livers were used for histopathological evaluation (light, electron and immunofluorescence microscopy) and biochemical analyses. Biochemical analyses revealed increased lipid peroxidation and glutathione values while catalase and superoxide dismutase values were decreased in electromagnetic field group. Electron microscopy evaluations identified necrotic hepatocytes with numerous cytoplasmic and mitochondrial vacuoles in electromagnetic field group sections. We also observed an enlarged endoplasmic reticulum and loss of mitochondrial matrix, in addition to the presence of vacuoles. Also, loss of inner and outer mitochondrial membrane integrity was observed. Light microscopy evaluations revealed sinusoidal capillary dilatation and degeneration in hepatocytes with cytoplasmic swelling, vacuolar degeneration and pyknotic nuclei in electromagnetic field group sections. Deterioration in the integrity of the collagen fibers was also present around the vena centralis. Additionally, electromagnetic field had no effect on body weight. Therefore, we conclude that continuous 900-megahertz electromagnetic field treatment may cause changes in oxidative stress biomarkers and the morphology of the adolescent rat liver.
dc.description.urihttps://doi.org/10.53447/communc.764890
dc.description.urihttps://avesis.atauni.edu.tr/publication/details/5d5db78c-6d18-4aeb-b650-47bc20486e28/oai
dc.description.urihttps://dergipark.org.tr/tr/pub/communc/issue/58411/764890
dc.identifier.doi10.53447/communc.764890
dc.identifier.endpage46
dc.identifier.issn1303-6025
dc.identifier.openairedoi_dedup___::9f3df4b1634df8d64ba8a93bd8c50dff
dc.identifier.orcid0000-0003-0716-5695
dc.identifier.orcid0000-0002-9121-536x
dc.identifier.orcid0000-0001-6927-3582
dc.identifier.orcid0000-0002-8506-1755
dc.identifier.orcid0000-0002-4875-9820
dc.identifier.orcid0000-0001-5756-5756
dc.identifier.orcid0000-0002-7473-2955
dc.identifier.orcid0000-0003-1646-8831
dc.identifier.startpage25
dc.identifier.urihttps://hdl.handle.net/20.500.12597/38878
dc.identifier.volume30
dc.language.isoeng
dc.publisherAnkara University
dc.relation.ispartofCommunications Faculty of Science University of Ankara Series C Biology Geological Engineering and Geophysical Engineering
dc.rightsOPEN
dc.subjectStructural Biology
dc.subjectYapısal Biyoloji
dc.subjectAdolescence
dc.subjectElectromagnetic field
dc.subjectHistopathology
dc.subjectLiver
dc.subjectOxidative stress
dc.subject.sdg3. Good health
dc.titleBIOCHEMICAL AND PATHOLOGICAL EFFECTS ON THE MALE RAT HEPATIC TISSUE AFTER EXPOSURE TO 900MHZ ELECTROMAGNETIC FIELD DURING ADOLESCENT PERIOD
dc.typeArticle
dspace.entity.typePublication
local.api.response{"authors":[{"fullName":"Ayşe İKİNCİ KELEŞ","name":"Ayşe","surname":"İKİNCİ KELEŞ","rank":1,"pid":{"id":{"scheme":"orcid","value":"0000-0003-0716-5695"},"provenance":null}},{"fullName":"Hüseyin Serkan EROL","name":"Hüseyin Serkan","surname":"EROL","rank":2,"pid":{"id":{"scheme":"orcid","value":"0000-0002-9121-536x"},"provenance":null}},{"fullName":"Tuğçe SAPMAZ","name":"Tuğçe","surname":"SAPMAZ","rank":3,"pid":{"id":{"scheme":"orcid_pending","value":"0000-0001-6927-3582"},"provenance":null}},{"fullName":"Tolga MERCANTEPE","name":"Tolga","surname":"MERCANTEPE","rank":4,"pid":{"id":{"scheme":"orcid","value":"0000-0002-8506-1755"},"provenance":null}},{"fullName":"Gökhan KELEŞ","name":"Gökhan","surname":"KELEŞ","rank":5,"pid":{"id":{"scheme":"orcid","value":"0000-0002-4875-9820"},"provenance":null}},{"fullName":"Burcu BİTERGE SÜT","name":"Burcu","surname":"BİTERGE SÜT","rank":6,"pid":{"id":{"scheme":"orcid","value":"0000-0001-5756-5756"},"provenance":null}},{"fullName":"Ersan ODACİ","name":"Ersan","surname":"ODACİ","rank":7,"pid":null},{"fullName":"Mesut HALICI","name":"Mesut","surname":"HALICI","rank":8,"pid":{"id":{"scheme":"orcid","value":"0000-0002-7473-2955"},"provenance":null}},{"fullName":"Sait POLAT","name":"Sait","surname":"POLAT","rank":9,"pid":{"id":{"scheme":"orcid_pending","value":"0000-0003-1646-8831"},"provenance":null}}],"openAccessColor":"gold","publiclyFunded":false,"type":"publication","language":{"code":"eng","label":"English"},"countries":null,"subjects":[{"subject":{"scheme":"keyword","value":"Structural Biology"},"provenance":null},{"subject":{"scheme":"keyword","value":"Yapısal Biyoloji"},"provenance":null},{"subject":{"scheme":"keyword","value":"Adolescence;Electromagnetic field;Histopathology;Liver;Oxidative stress"},"provenance":null},{"subject":{"scheme":"SDG","value":"3. Good health"},"provenance":null}],"mainTitle":"BIOCHEMICAL AND PATHOLOGICAL EFFECTS ON THE MALE RAT HEPATIC TISSUE AFTER EXPOSURE TO 900MHZ ELECTROMAGNETIC FIELD DURING ADOLESCENT PERIOD","subTitle":null,"descriptions":["<jats:p xml:lang=\"en\">The aim of this study was to employ biochemical analysis and histopathological techniques to investigate the effects of the application of a 900-megahertz electromagnetic field during adolescence on the rat liver. 24 male Sprague Dawley rats aged 21 days were randomly divided into electromagnetic field, sham and control groups. No procedure was performed on the control group rats. Electromagnetic field group rats were exposed to a 900-megahertz electromagnetic field in an electromagnetic field application cage (1 hours/day, every day for 25 days). The sham group rats were placed in the same electromagnetic field cage without exposure to electromagnetic field. At the end of the experiments, the livers were removed. The livers were used for histopathological evaluation (light, electron and immunofluorescence microscopy) and biochemical analyses. Biochemical analyses revealed increased lipid peroxidation and glutathione values while catalase and superoxide dismutase values were decreased in electromagnetic field group. Electron microscopy evaluations identified necrotic hepatocytes with numerous cytoplasmic and mitochondrial vacuoles in electromagnetic field group sections. We also observed an enlarged endoplasmic reticulum and loss of mitochondrial matrix, in addition to the presence of vacuoles. Also, loss of inner and outer mitochondrial membrane integrity was observed. Light microscopy evaluations revealed sinusoidal capillary dilatation and degeneration in hepatocytes with cytoplasmic swelling, vacuolar degeneration and pyknotic nuclei in electromagnetic field group sections. Deterioration in the integrity of the collagen fibers was also present around the vena centralis. Additionally, electromagnetic field had no effect on body weight. Therefore, we conclude that continuous 900-megahertz electromagnetic field treatment may cause changes in oxidative stress biomarkers and the morphology of the adolescent rat liver.</jats:p>"],"publicationDate":"2021-06-30","publisher":"Ankara University","embargoEndDate":null,"sources":["Crossref","Volume: 30, Issue: 1 25-46","1303-6025","2651-3749","Communications Faculty of Sciences University of Ankara Series C Biology","-"],"formats":["application/pdf"],"contributors":null,"coverages":null,"bestAccessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/"},"container":{"name":"Communications Faculty of Science University of Ankara Series C Biology Geological Engineering and Geophysical Engineering","issnPrinted":"1303-6025","issnOnline":null,"issnLinking":null,"ep":"46","iss":null,"sp":"25","vol":"30","edition":null,"conferencePlace":null,"conferenceDate":null},"documentationUrls":null,"codeRepositoryUrl":null,"programmingLanguage":null,"contactPeople":null,"contactGroups":null,"tools":null,"size":null,"version":null,"geoLocations":null,"id":"doi_dedup___::9f3df4b1634df8d64ba8a93bd8c50dff","originalIds":["10.53447/communc.764890","50|doiboost____|9f3df4b1634df8d64ba8a93bd8c50dff","50|od______9933::c6140b8c4e9d91d73e71014d66ddaa64","5d5db78c-6d18-4aeb-b650-47bc20486e28","oai:dergipark.org.tr:article/764890","50|tubitakulakb::5be52f08a8fbaf2cba92ace8f42bac86"],"pids":[{"scheme":"doi","value":"10.53447/communc.764890"}],"dateOfCollection":null,"lastUpdateTimeStamp":null,"indicators":{"citationImpact":{"citationCount":2,"influence":2.587934e-9,"popularity":3.152469e-9,"impulse":2,"citationClass":"C5","influenceClass":"C5","impulseClass":"C5","popularityClass":"C5"}},"instances":[{"pids":[{"scheme":"doi","value":"10.53447/communc.764890"}],"type":"Article","urls":["https://doi.org/10.53447/communc.764890"],"publicationDate":"2021-06-30","refereed":"peerReviewed"},{"type":"Article","urls":["https://avesis.atauni.edu.tr/publication/details/5d5db78c-6d18-4aeb-b650-47bc20486e28/oai"],"publicationDate":"2021-01-01","refereed":"nonPeerReviewed"},{"alternateIdentifiers":[{"scheme":"doi","value":"10.53447/communc.764890"}],"type":"Article","urls":["https://dergipark.org.tr/tr/pub/communc/issue/58411/764890"],"publicationDate":"2020-07-06","refereed":"nonPeerReviewed"}],"isGreen":true,"isInDiamondJournal":false}
local.import.sourceOpenAire

Dosyalar

Koleksiyonlar

Publications