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Association of B7-H4 gene polymorphisms in urothelial bladder cancer

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dc.contributor.authorDi̇nçel, Deni̇z
dc.contributor.authorŞamli, Hale
dc.contributor.authorBalci, Faruk
dc.contributor.authorSağlican, Yeşim
dc.contributor.authorİnce, Ümit
dc.contributor.authorŞahi̇n, Ahmet
dc.contributor.authorSamli, Murat
dc.contributor.authorOzgoz, Asuman
dc.date.accessioned2026-01-02T23:55:09Z
dc.date.issued2017-01-01
dc.description.abstractWe aimed to study polymorphisms of the B7-H4 gene in order to evaluate a possible association in urothelial carcinoma, as it is highly expressed in cancer tissues.In this study B7-H4 gene rs10754339, rs10801935, and rs3738414 SNPs were studied by PCR-RFLP method in paraffin-embedded tumor specimens from 62 urothelial carcinoma patients and in a control group including 30 patients without bladder cancer.We detected that the rs10754339 polymorphism was more frequent in the cancer patients when compared with the control group (P < 0.05). Only the rs3738414 polymorphism showed a statistically significant difference in frequency between pathologic diagnostic groups.The rs10754339 AA genotype distribution was found to have a higher frequency whereas the rs3738414 AG genotype distribution was lower in the bladder cancer group (P < 0.05). None of the genotype distributions showed a significant difference from the control group for the rs10801935 polymorphism. We conclude that B7-H4 has the potential to be a useful prognostic marker in urothelial carcinoma.
dc.description.urihttps://doi.org/10.3906/sag-1603-54
dc.description.urihttps://pubmed.ncbi.nlm.nih.gov/28425229
dc.description.urihttps://dx.doi.org/10.3906/sag-1603-54
dc.description.urihttps://hdl.handle.net/11443/1917
dc.description.urihttps://avesis.uludag.edu.tr/publication/details/a6c3a215-6008-4622-9a9b-0f88fd8d5b39/oai
dc.identifier.doi10.3906/sag-1603-54
dc.identifier.eissn1303-6165
dc.identifier.endpage446
dc.identifier.issn1300-0144
dc.identifier.openairedoi_dedup___::079504782b2eee21d5c03c882648e8fe
dc.identifier.orcid0000-0003-1354-988x
dc.identifier.pubmed28425229
dc.identifier.scopus2-s2.0-85018778719
dc.identifier.startpage443
dc.identifier.urihttps://hdl.handle.net/20.500.12597/36354
dc.identifier.volume47
dc.identifier.wos000399829700012
dc.publisherThe Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS
dc.relation.ispartofTURKISH JOURNAL OF MEDICAL SCIENCES
dc.rightsOPEN
dc.subjectMale
dc.subjectBladder cancer
dc.subjectMiddle Aged
dc.subjectV-Set Domain-Containing T-Cell Activation Inhibitor 1
dc.subjectReal-Time Polymerase Chain Reaction
dc.subjectPolymorphism, Single Nucleotide
dc.subjectpolymorphism
dc.subjectGene Frequency
dc.subjectUrinary Bladder Neoplasms
dc.subjectPredictive Value of Tests
dc.subjectBiomarkers, Tumor
dc.subjectHumans
dc.subjectB7-H4 gene
dc.subjectFemale
dc.subjectUrothelium
dc.subjectGenetic Association Studies
dc.subjectAged
dc.subject.sdg3. Good health
dc.titleAssociation of B7-H4 gene polymorphisms in urothelial bladder cancer
dc.typeArticle
dspace.entity.typePublication
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