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Novel in vitro and in silico insights of the multi-biological activities and chemical composition of Bidens tripartita L.

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dc.contributor.authorUysal, Sengul
dc.contributor.authorUgurlu, Asli
dc.contributor.authorZengin, Gokhan
dc.contributor.authorBaloglu, Mehmet Cengiz
dc.contributor.authorAltunoglu, Yasemin Celik
dc.contributor.authorMollica, Adriano
dc.contributor.authorCustodio, Luisa
dc.contributor.authorNeng, Nuno R.
dc.contributor.authorNogueira, José M. F.
dc.contributor.authorMahomoodally, M. Fawzi
dc.date.accessioned2026-01-03T10:21:55Z
dc.date.issued2018-01-01
dc.description.abstractBidens tripartita L. is a traditional phyto-remedy used in several countries, yet there is still a paucity of data on its biological potential. We aimed to provide new insights on the pharmacological potential of extracts prepared from B. tripartita via highlighting its antioxidant, key enzymes inhibitory potency, and DNA protecting effects. Phytochemical profile was established using High-Performance Liquid Chromatography with Diode-Array Detection (HPLC-DAD) and bioactive compound(s) docked against target enzymes using in silico methods. Cytotoxicity against three cancer cell lines was assessed using the methylthiazolyldiphenyl-tetrazolium bromide (MTT) cell viability test. The main compounds were luteolin-7-glucoside (cynaroside), chlorogenic acid, and epicatechin in the extracts. The methanol extract exhibited the highest radical scavenging activity. Ethyl acetate extract showed strongest α-amylase inhibitory activity, while the best α-glucosidase inhibitory effect recorded for the methanol extract. Molecular docking showed that cynaroside strongly interact to α-glucosidase cavity by establishing six hydrogen bonds. B. tripartita extracts were found to protect supercoiled form of pUC19 plasmid (>70%) and also showed anti-proliferative properties. Results amassed in the present study add on to a growing body of literature on the multi-pharmacological potency of B. tripartita which can be applied to bio-products development geared towards management of common diseases.
dc.description.urihttps://doi.org/10.1016/j.fct.2017.11.058
dc.description.urihttps://pubmed.ncbi.nlm.nih.gov/29217268
dc.description.urihttps://dx.doi.org/10.1016/j.fct.2017.11.058
dc.description.urihttps://hdl.handle.net/11564/685236
dc.description.urihttps://hdl.handle.net/20.500.12395/36809
dc.description.urihttps://avesis.erciyes.edu.tr/publication/details/ca4182d1-2a33-463b-bcef-4b51a3a066dc/oai
dc.identifier.doi10.1016/j.fct.2017.11.058
dc.identifier.endpage536
dc.identifier.issn0278-6915
dc.identifier.openairedoi_dedup___::d1644dc0ed60ab802e98b4bde2e8dfad
dc.identifier.orcid0000-0003-4562-1719
dc.identifier.orcid0000-0003-2131-2823
dc.identifier.orcid0000-0001-6548-7823
dc.identifier.orcid0000-0003-2976-7224
dc.identifier.orcid0000-0002-7242-4860
dc.identifier.orcid0000-0001-9879-1565
dc.identifier.orcid0000-0001-5785-6780
dc.identifier.pubmed29217268
dc.identifier.scopus2-s2.0-85037711133
dc.identifier.startpage525
dc.identifier.urihttps://hdl.handle.net/20.500.12597/36665
dc.identifier.volume111
dc.identifier.wos000423248100047
dc.language.isoeng
dc.publisherElsevier BV
dc.relation.ispartofFood and Chemical Toxicology
dc.rightsCLOSED
dc.subjectAnti-proliferative
dc.subjectAnti-cancer
dc.subjectCell Survival
dc.subjectPlant Extracts
dc.subjectDNA protection
dc.subjectalpha-Glucosidases
dc.subjectCell Line
dc.subjectMolecular Docking Simulation
dc.subjectAnti-cancer
dc.subjectAnti-proliferative
dc.subjectAntioxidant
dc.subjectCholinesterases
dc.subjectDNA protection
dc.subjectα-glucosidase
dc.subjectFood Science
dc.subjectToxicology
dc.subjectCholinesterases
dc.subjectalpha-glucosidase
dc.subjectComputer Simulation
dc.subjectAntioxidant
dc.subjectBidens
dc.subjectChromatography, High Pressure Liquid
dc.subject.sdg3. Good health
dc.titleNovel in vitro and in silico insights of the multi-biological activities and chemical composition of Bidens tripartita L.
dc.typeArticle
dspace.entity.typePublication
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