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Biological Activities and Biochemical Composition of Endemic Achillea fraasii

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dc.contributor.authorTunca-Pinarli, Yagmur
dc.contributor.authorBenek, Atakan
dc.contributor.authorTuru, Dilay
dc.contributor.authorBozyel, Mustafa Eray
dc.contributor.authorCanli, Kerem
dc.contributor.authorAltuner, Ergin Murat
dc.date.accessioned2026-01-04T18:36:31Z
dc.date.issued2023-04-09
dc.description.abstractIn this study, we investigated the antimicrobial, antioxidant, and antibiofilm activities and the biochemical composition of Achillea fraasii. The antimicrobial activity of A. fraasii ethanol extract (AFEt) was tested against 48 strains, and this is the first study testing the antimicrobial activity of this plant to this extent. The antioxidant activity was determined using the DPPH assay, and the antibiofilm activity of A. fraasii aqueous extract (AFAq) against five strains was assessed. The chemical composition of the plant extract was determined using GC-MS with artemisia ketone (19.41%) as the main component. The findings indicated that AFEt displayed antimicrobial activity against 38 strains, with a particular efficacy observed against various Staphylococcus aureus strains, such as S. aureus ATCC 25923, clinically isolated, multidrug resistant (MDR), and methicillin-resistant (MRSA) strains. In addition, the highest activity was observed against Enterococcus faecium. Moreover, the extract demonstrated activity against Candida strains. The plant extract also showed relatively good antioxidant activity compared to ascorbic acid, with an EC50 value of 55.52 µg/mL. However, AFAq acted as a biofilm activator against Escherichia coli ATCC 25922, increasing the biofilm formation by 2.63-fold. In conclusion, our study demonstrates the potential of A. fraasii as a source of antimicrobial and antioxidant agents.
dc.description.urihttps://doi.org/10.3390/microorganisms11040978
dc.description.urihttps://pubmed.ncbi.nlm.nih.gov/37110401
dc.description.urihttp://dx.doi.org/10.3390/microorganisms11040978
dc.description.urihttps://doaj.org/article/b7aed858c2d74bdd8cd3d87a0b128f90
dc.description.urihttps://dx.doi.org/10.3390/microorganisms11040978
dc.description.urihttps://avesis.deu.edu.tr/publication/details/455854c9-6f6c-418e-82a1-f5c1b26fb848/oai
dc.description.urihttps://avesis.comu.edu.tr/publication/details/455854c9-6f6c-418e-82a1-f5c1b26fb848/oai
dc.identifier.doi10.3390/microorganisms11040978
dc.identifier.eissn2076-2607
dc.identifier.openairedoi_dedup___::66b0914547b9a5e92872368b153f18b3
dc.identifier.orcid0000-0002-3434-0623
dc.identifier.orcid0000-0001-6726-5968
dc.identifier.orcid0000-0002-8485-0488
dc.identifier.orcid0000-0001-5556-4880
dc.identifier.orcid0000-0001-5351-8071
dc.identifier.pubmed37110401
dc.identifier.scopus2-s2.0-85156254702
dc.identifier.startpage978
dc.identifier.urihttps://hdl.handle.net/20.500.12597/40645
dc.identifier.volume11
dc.identifier.wos000978141300001
dc.language.isoeng
dc.publisherMDPI AG
dc.relation.ispartofMicroorganisms
dc.rightsOPEN
dc.subjectantibacterial activity
dc.subjectQH301-705.5
dc.subject<i>Achillea fraasii</i>
dc.subjectantibacterial activity
dc.subjectantifungal activity
dc.subjectantioxidant activity
dc.subjectantibiofilm activity
dc.subjectGC-MS
dc.subjectantifungal activity
dc.subjectantioxidant activity
dc.subjectantibiofilm activity
dc.subjectGC-MS
dc.subjectBiology (General)
dc.subject<i>Achillea fraasii</i>
dc.subjectArticle
dc.subject.sdg3. Good health
dc.titleBiological Activities and Biochemical Composition of Endemic Achillea fraasii
dc.typeArticle
dspace.entity.typePublication
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