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Immune responses to methanolic extract of black cumin ( Nigella sativa ) in rainbow trout ( Oncorhynchus mykiss )

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dc.contributor.authorCelik Altunoglu, Yasemin
dc.contributor.authorBilen, Soner
dc.contributor.authorUlu, Ferhat
dc.contributor.authorBiswas, Gouranga
dc.date.accessioned2026-01-03T10:08:25Z
dc.date.issued2017-08-01
dc.description.abstractThe immune stimulating effects of the methanolic extract of black cumin (Nigella sativa) in rainbow trout (Oncorhynchus mykiss) was evaluated. Variable concentrations of black cumin methanolic extract [0 (Control), 0.1 and 0.5 g kg-1 of feed] were individually added to the basal diet and rainbow trout was fed for 30 days to assess the innate immune responses and growth performance. Feed conversion ratio significantly decreased in the group fed with 0.5 g kg-1 black cumin extract. Respiratory burst activity was observed to be the highest in the 0.5 g kg-1 black cumin extract fed group. Lysozyme and myeloperoxidase activities were significantly increased in fish of experimental groups compared to control (P < 0.05). TGF-β gene expression increased in black cumin 0.5 g kg-1 treated group. IL-1β and TGF-β gene expressions decreased in black cumin 0.1 g kg-1 administered group. Expression of IL-12 gene diminished in both the experimental groups. There was no significant difference in survival rates between black cumin extract treated fish groups and control (P > 0.05) after challenged with Aeromonas hydrophila. The results indicate that the methanolic extract of black cumin is a stimulator of some innate humoral immune responses, but it is ineffective for cytokine-related gene trancriptions in rainbow trout.
dc.description.urihttps://doi.org/10.1016/j.fsi.2017.06.002
dc.description.urihttps://pubmed.ncbi.nlm.nih.gov/28602677
dc.description.urihttps://dx.doi.org/10.1016/j.fsi.2017.06.002
dc.identifier.doi10.1016/j.fsi.2017.06.002
dc.identifier.endpage109
dc.identifier.issn1050-4648
dc.identifier.openairedoi_dedup___::56a77a4e818038b38d57399e272ac202
dc.identifier.orcid0000-0001-9459-8178
dc.identifier.orcid0000-0002-9407-9084
dc.identifier.pubmed28602677
dc.identifier.scopus2-s2.0-85020296521
dc.identifier.startpage103
dc.identifier.urihttps://hdl.handle.net/20.500.12597/36510
dc.identifier.volume67
dc.identifier.wos000406726300012
dc.language.isoeng
dc.publisherElsevier BV
dc.relation.ispartofFish &amp; Shellfish Immunology
dc.rightsCLOSED
dc.subjectPlant Extracts
dc.subjectAnimal Feed
dc.subjectImmunity, Innate
dc.subjectAeromonas hydrophila
dc.subjectDiet
dc.subjectFish Diseases
dc.subjectOncorhynchus mykiss
dc.subjectDietary Supplements
dc.subjectAnimals
dc.subjectNigella sativa
dc.subjectGram-Negative Bacterial Infections
dc.subject.sdg3. Good health
dc.subject.sdg14. Life underwater
dc.titleImmune responses to methanolic extract of black cumin ( Nigella sativa ) in rainbow trout ( Oncorhynchus mykiss )
dc.typeArticle
dspace.entity.typePublication
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