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Expression of ADAMTS-7 in myocardial dystrophy associated with white muscle disease in lambs

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dc.contributor.authorHi̇ti̇t, Mustafa
dc.contributor.authorYilmaz, Rahşan
dc.contributor.authorPolat Di̇nçer, Peli̇n Fatoş
dc.contributor.authorYumuşak, Ni̇hat
dc.contributor.authorYi̇ği̇n, Akin
dc.date.accessioned2026-01-06T06:04:53Z
dc.date.issued2018-02-13
dc.description.abstractThe aim of the present study was to investigate the role of ADAMTS-7 gene in the pathogenesis of myocardial dystrophy associated with white muscle disease (WMD) in lambs. A total of 217 cardiac tissue samples from lambs with WMD were used in the study. Histopathological sections of the samples were stained with hematoxylin-eosin (HE) and examined using Western-blot, real-time PCR (RT-PCR) and immunohistochemistry for ADAMTS-7 gene expression, and the findings were statistically evaluated. Histopathological examinations revealed fibrosis associated with hyalinization, necrosis and granular calcifications in cardiomyocytes. Western blot and RT-PCR showed a statistically significant upregulation of ADAMTS-7 (p<0.05) (p<0.05). Immunohistochemical analyses showed that immunopositive cell numbers significantly high for ADAMTS-7 (p<0.05). The study has revealed that ADAMTS-7 gene is significantly expressed in myocardial dystrophy associated with WMD in addition to its role in the pathogenesis of this disease.
dc.description.urihttps://doi.org/10.24425/119029
dc.description.urihttps://dx.doi.org/10.24425/119029
dc.description.urihttps://pubmed.ncbi.nlm.nih.gov/29624002
dc.description.urihttps://avesis.deu.edu.tr/publication/details/a4aebe7c-f810-426d-92a3-28a2626e972a/oai
dc.description.urihttps://avesis.deu.edu.tr/publication/details/0e643e43-b13a-494f-9447-2e5a1aad5094/oai
dc.identifier.doi10.24425/119029
dc.identifier.issn1505-1773
dc.identifier.openairedoi_dedup___::ed7d175d0848b5753781a7365f91f858
dc.identifier.orcid0000-0001-5636-061x
dc.identifier.pubmed29624002
dc.identifier.scopus2-s2.0-85184936940
dc.identifier.urihttps://hdl.handle.net/20.500.12597/43889
dc.identifier.wos000432043500014
dc.language.isopol
dc.publisherPolish Academy of Sciences Chancellery
dc.relation.ispartofPolish Journal of Veterinary Sciences
dc.rightsCLOSED
dc.subjectGene Expression Regulation
dc.subjectWhite Muscle Disease
dc.subjectADAMTS7 Protein
dc.subjectAnimals
dc.subjectHumans
dc.subjectGenetic Predisposition to Disease
dc.subjectCardiomyopathies
dc.titleExpression of ADAMTS-7 in myocardial dystrophy associated with white muscle disease in lambs
dc.typeArticle
dspace.entity.typePublication
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