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Effects of sub-chronic exposure of male albino rats to some insecticides on mitochondrial dysfunction and oxidative stress in the kidney with molecular docking

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dc.contributor.authorTaha, Mostafa
dc.contributor.authorBadawy, Mohamed
dc.contributor.authorAbdel-razik, Reda
dc.contributor.authorYounis, Hassan
dc.contributor.authorAbo-el-saad, Mahmoud
dc.date.accessioned2026-01-04T16:44:02Z
dc.date.issued2022-04-21
dc.description.abstractThe present study evaluated the adverse effects of three widely used insecticides in the Egyptian environment on mitochondrial bioenergetic and oxidative stress biomarkers in the rat kidney. Chlorpyrifos, cypermethrin, and imidacloprid were orally administrated to male albino rats at 1/50 of the LD50 for 28 days by 5 doses /week. The insecticides caused a significant in vivo decrease in the activities of mitochondrial bioenergetic biomarkers; NADH dehydrogenase, adenosine triphosphatase (ATPase) and mitochondrial oxidative stress biomarkers; superoxide dismutase (SOD), and glutathione S- transferase (GST) while the malondialdehyde (MDA) and protein carbonyl contents (PCC) were significantly increased. Further, chromatography analysis demonstrated that 8-hydroxy-2'-deoxyguanosine (8-OH-2DG) increased considerably in rat urine as a DNA damage biomarker. The kidney deficiency was confirmed by histological examination and in silico simulation analysis (Molecular docking and absorption, distribution, metabolism, excretion, and toxicity (ADMET)). The alterations in the tested parameters were confirmed by the symptoms of histological deformation in kidney tissues, demonstrating the hazardous effects. The laboratory results showed the impact of the tested insecticides in conformity with the in silico simulation analysis (molecular docking and ADMET).
dc.description.urihttps://doi.org/10.37212/jcnos.1080039
dc.description.urihttps://dergipark.org.tr/tr/pub/jcnos/issue/69517/1080039
dc.identifier.doi10.37212/jcnos.1080039
dc.identifier.eissn2149-7222
dc.identifier.openairedoi_dedup___::8c04fbe2acea92c5aedcc674e7abcc92
dc.identifier.orcid0000-0002-9159-454x
dc.identifier.orcid0000-0002-6923-5452
dc.identifier.orcid0000-0002-0003-744x
dc.identifier.orcid0000-0001-8511-7651
dc.identifier.orcid0000-0003-2679-9992
dc.identifier.scopus2-s2.0-85218625260
dc.identifier.urihttps://hdl.handle.net/20.500.12597/39640
dc.identifier.volume13
dc.publisherJournal of Cellular Neuroscience and Oxidative Stress
dc.relation.ispartofJournal of Cellular Neuroscience and Oxidative Stress
dc.rightsOPEN
dc.subjectOxidative stress
dc.subjectRat kidney
dc.subjectMitochondria
dc.subjectInsecticides
dc.subjectHPLC analysis
dc.subjectMolecular docking
dc.subjectToxicology
dc.subjectToksikoloji
dc.subject.sdg3. Good health
dc.titleEffects of sub-chronic exposure of male albino rats to some insecticides on mitochondrial dysfunction and oxidative stress in the kidney with molecular docking
dc.typeArticle
dspace.entity.typePublication
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