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Cytotoxic Compounds from Endemic Arnebia purpurea

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dc.contributor.authorHarput, U. Sebnem
dc.contributor.authorDuman, Hayri
dc.contributor.authorBilgili, Bilgehan
dc.contributor.authorGüvenalp, Zühal
dc.contributor.authorSaraçoğlu, İclal
dc.contributor.authorYuzbasioglu, Merve
dc.contributor.authorToth, Gabor
dc.contributor.authorDemirezer, L. Omur
dc.contributor.authorSimon, Andras
dc.contributor.authorKazaz, Cavit
dc.contributor.authorKuruuzum-Uz, Ayse
dc.date.accessioned2026-01-02T23:22:15Z
dc.date.issued2015-04-01
dc.description.abstractPhytochemical studies of the roots and aerial parts of endemic Arnebia purpurea S. Erik & H. Sumbul resulted in the isolation and characterization of four naphthoquinones [isovalerylalkannin (1), α-methyl- n-butanoyl alkannin (2), acetylalkannin (3), and alkannin (4)], a triterpene derivative [3- O-acetyl-oleanolic acid (5)], a steroid [β-sitosterol (6)], three flavonoid glycosides [isorhamnetin-3- O-rutinoside (7), kaempferol-3- O-rutinoside (8), kaempferol 3- O-(5″-acetyl) apiofuranoside 7- O-rhamnopyranoside (9)] and a phenolic acid [rosmarinic acid (10)]. 3- O-Acetyl-oleanolic acid, isorhamnetin-3- O-rutinoside, kaempferol-3- O-rutinoside, and kaempferol 3- O-(5″-acetyl) apiofuranoside 7- O-rhamnopyranoside are reported from an Arnebia species for the first time. Cytotoxic activities on L929 murine fibrosarcoma cell line of the isolated compounds were investigated using MTT assay. Naphthoquinones (1–4) showed intermediate cytotoxic activity in comparison with the standard, doxorubicin.
dc.description.urihttps://doi.org/10.1177/1934578x1501000415
dc.description.urihttps://journals.sagepub.com/doi/pdf/10.1177/1934578X1501000415
dc.description.urihttps://pubmed.ncbi.nlm.nih.gov/25973485
dc.description.urihttps://dx.doi.org/10.1177/1934578x1501000415
dc.description.urihttps://avesis.gazi.edu.tr/publication/details/57a4e543-bd1e-49a6-9dc2-13dd362f2c1e/oai
dc.description.urihttps://avesis.atauni.edu.tr/publication/details/57a4e543-bd1e-49a6-9dc2-13dd362f2c1e/oai
dc.identifier.doi10.1177/1934578x1501000415
dc.identifier.eissn1555-9475
dc.identifier.issn1934-578X
dc.identifier.openairedoi_dedup___::44d2e33598cc5410729a6290cd0ccead
dc.identifier.orcid0000-0003-0555-6262
dc.identifier.orcid0000-0002-7482-0429
dc.identifier.orcid0000-0002-5249-0895
dc.identifier.orcid0000-0003-3373-4759
dc.identifier.scopus2-s2.0-84933523300
dc.identifier.urihttps://hdl.handle.net/20.500.12597/35971
dc.identifier.volume10
dc.language.isoeng
dc.publisherSAGE Publications
dc.relation.ispartofNatural Product Communications
dc.rightsOPEN
dc.subjectFibrosarcoma
dc.subjectPlant Components, Aerial
dc.subjectBoraginaceae
dc.subjectAntineoplastic Agents, Phytogenic
dc.subjectPlant Roots
dc.subjectMice
dc.subjectCell Line, Tumor
dc.subjectAnimals
dc.subjectNaphthoquinones
dc.subject.sdg16. Peace & justice
dc.subject.sdg3. Good health
dc.titleCytotoxic Compounds from Endemic Arnebia purpurea
dc.typeArticle
dspace.entity.typePublication
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Sumbul resulted in the isolation and characterization of four naphthoquinones [isovalerylalkannin (1), α-methyl- n-butanoyl alkannin (2), acetylalkannin (3), and alkannin (4)], a triterpene derivative [3- O-acetyl-oleanolic acid (5)], a steroid [β-sitosterol (6)], three flavonoid glycosides [isorhamnetin-3- O-rutinoside (7), kaempferol-3- O-rutinoside (8), kaempferol 3- O-(5″-acetyl) apiofuranoside 7- O-rhamnopyranoside (9)] and a phenolic acid [rosmarinic acid (10)]. 3- O-Acetyl-oleanolic acid, isorhamnetin-3- O-rutinoside, kaempferol-3- O-rutinoside, and kaempferol 3- O-(5″-acetyl) apiofuranoside 7- O-rhamnopyranoside are reported from an Arnebia species for the first time. Cytotoxic activities on L929 murine fibrosarcoma cell line of the isolated compounds were investigated using MTT assay. 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