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Alterations of Tear Film and Ocular Surface in Children with Type 1 Diabetes Mellitus

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dc.contributor.authorInanc, Merve
dc.contributor.authorKiziltoprak, Hasan
dc.contributor.authorHekimoglu, Rumeysa
dc.contributor.authorTekin, Kemal
dc.contributor.authorOzalkak, Servan
dc.contributor.authorKoc, Mustafa
dc.contributor.authorBayramoglu, Elvan
dc.contributor.authorZirh, Selim
dc.contributor.authorYuruker, Sinan
dc.contributor.authorAycan, Zehra
dc.date.accessioned2026-01-04T12:42:48Z
dc.date.issued2019-02-26
dc.description.abstractPurpose: To investigate whether diabetes mellitus (DM) affects ocular surface of children with well-controlled type 1 DM.Methods: Sixty-five diabetic patients and 55 age-matched controls enrolled to study. Detailed ocular surface assessment including, ocular surface disease index (OSDI) questionnaire, tear film break-up time (TBUT) analysis, Schirmer test, and conjunctival impression cytologic analysis were performed.Results: Schirmer test and TBUT results were significantly lower in DM group than controls (p = 0.001, for all). OSDI scores of all participants were within normal range. Impression cytology analysis showed grade 0 changes in all participants and there was no difference between groups for goblet cell density (p > 0.05). The TBUT results were significantly associated with duration of DM (r = -0.309, p = 0.036).Conclusion: Diabetic children without symptoms, signs, and definite diagnosis of dry eye still had lower TBUT and Schirmer test results than controls; however, impression cytology analysis was similar in both groups.
dc.description.urihttps://doi.org/10.1080/09273948.2019.1571212
dc.description.urihttps://pubmed.ncbi.nlm.nih.gov/30806526
dc.description.urihttps://dx.doi.org/10.1080/09273948.2019.1571212
dc.description.urihttps://hdl.handle.net/20.500.12636/1609
dc.description.urihttps://hdl.handle.net/20.500.12645/11160
dc.identifier.doi10.1080/09273948.2019.1571212
dc.identifier.eissn1744-5078
dc.identifier.endpage369
dc.identifier.issn0927-3948
dc.identifier.openairedoi_dedup___::56d62a14c9656a41da928fe16b9dbde8
dc.identifier.orcid0000-0002-9930-7680
dc.identifier.orcid0000-0001-7100-9107
dc.identifier.orcid0000-0003-4300-7213
dc.identifier.orcid0000-0002-7461-6129
dc.identifier.orcid0000-0002-6732-8823
dc.identifier.orcid0000-0002-7962-6078
dc.identifier.pubmed30806526
dc.identifier.scopus2-s2.0-85062375175
dc.identifier.startpage362
dc.identifier.urihttps://hdl.handle.net/20.500.12597/37236
dc.identifier.volume28
dc.identifier.wos000526443300005
dc.language.isoeng
dc.publisherInforma UK Limited
dc.relation.ispartofOcular Immunology and Inflammation
dc.rightsOPEN
dc.subjectMale
dc.subjectocular surface
dc.subjectAdolescent
dc.subjectimpression cytology
dc.subjectSlit Lamp Microscopy
dc.subjectdry eye
dc.subjectCross-Sectional Studies
dc.subjectDiabetes Mellitus, Type 1
dc.subjectSurveys and Questionnaires
dc.subjectTears
dc.subjectHumans
dc.subjectDry Eye Syndromes
dc.subjectFemale
dc.subjectProspective Studies
dc.subjectChild
dc.subjecttear film
dc.subjectConjunctiva
dc.subjectmellitus
dc.subject.sdg3. Good health
dc.titleAlterations of Tear Film and Ocular Surface in Children with Type 1 Diabetes Mellitus
dc.typeArticle
dspace.entity.typePublication
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