Yayın:
Exploring of the ameliorative effects of Nerium (Nerium oleander L.) ethanolic flower extract in streptozotocin induced diabetic rats via biochemical, histological and molecular aspects

Basit Görünüm
dc.contributor.authorBattal, Abdulhamit
dc.contributor.authorDogan, Abdulahad
dc.contributor.authorUyar, Ahmet
dc.contributor.authorDemir, Abdulbaki
dc.contributor.authorKeleş, Ömer Faruk
dc.contributor.authorCelik, Ismail
dc.contributor.authorBaloglu, Mehmet Cengiz
dc.contributor.authorAslan, Ali
dc.date.accessioned2026-01-04T18:28:41Z
dc.date.issued2023-03-10
dc.description.abstractNerium oleander L. is ethnopharmacologically used for diabetes. Our aim was to investigate the ameliorative effects of ethanolic Nerium flower extract (NFE) in STZ-induced diabetic rats.Seven random groups including control group, NFE group (50 mg/kg), diabetic group, glibenclamide group and NFE treated groups (25 mg/kg, 75 mg/kg, and 225 mg/kg) were composed of forty-nine rats. Blood glucose level, glycated hemoglobin (HbA1c), insulin level, liver damage parameters and lipid profile parameters were investigated. Antioxidant defense system enzyme activities and reduced glutathione (GSH) and malondialdehyde (MDA) contents and immunotoxic and neurotoxic parameters were determined in liver tissue. Additionally, the ameliorative effects of NFE were histopathologically examined in liver. mRNA levels of SLC2A2 gene encoding glucose transporter 2 protein were measured by quantitative real time PCR.NFE caused decrease in glucose level and HbA1c and increase in insulin and C-peptide levels. Additionally, NFE improved liver damage biomarkers and lipid profile parameters in serum. Moreover, lipid peroxidation was prevented and antioxidant enzyme activities in liver were regulated by NFE treatment. Furthermore, anti-immunotoxic and anti-neurotoxic effects of NFE were determined in liver tissue of diabetic rats. Histopathogically, significant liver damages were observed in the diabetic rats. Histopathological changes were decreased partially in the 225 mg/kg NFE treated group. SLC2A2 gene expression in liver of diabetic rats significantly reduced compared to healthy rats and NFE treatment (25 mg/kg) caused increase in gene expression.Flower extract of Nerium plant may have an antidiabetic potential due to its high phytochemical content.
dc.description.urihttps://doi.org/10.1007/s11033-023-08332-5
dc.description.urihttps://pubmed.ncbi.nlm.nih.gov/36897524
dc.description.urihttps://avesis.yyu.edu.tr/publication/details/2054e126-ca81-49d5-a50c-d69e7f72dc20/oai
dc.identifier.doi10.1007/s11033-023-08332-5
dc.identifier.eissn1573-4978
dc.identifier.endpage4205
dc.identifier.issn0301-4851
dc.identifier.openairedoi_dedup___::eb8b068ecc90129412c00a5657895500
dc.identifier.orcid0000-0001-6098-3908
dc.identifier.orcid0000-0002-5438-8560
dc.identifier.orcid0000-0003-4345-6756
dc.identifier.orcid0000-0002-6867-4410
dc.identifier.orcid0000-0002-7869-5311
dc.identifier.orcid0000-0003-2199-6348
dc.identifier.orcid0000-0003-2976-7224
dc.identifier.orcid0000-0002-5122-6646
dc.identifier.pubmed36897524
dc.identifier.scopus2-s2.0-85149762790
dc.identifier.startpage4193
dc.identifier.urihttps://hdl.handle.net/20.500.12597/40557
dc.identifier.volume50
dc.identifier.wos000947251400002
dc.language.isoeng
dc.publisherSpringer Science and Business Media LLC
dc.relation.ispartofMolecular Biology Reports
dc.rightsCLOSED
dc.subjectGlycated Hemoglobin
dc.subjectBlood Glucose
dc.subjectPlant Extracts
dc.subjectFlowers
dc.subjectLipids
dc.subjectAntioxidants
dc.subjectStreptozocin
dc.subjectRats
dc.subjectDiabetes Mellitus, Experimental
dc.subjectLiver
dc.subjectAnimals
dc.subjectHypoglycemic Agents
dc.subjectInsulin
dc.subjectNerium
dc.subject.sdg3. Good health
dc.titleExploring of the ameliorative effects of Nerium (Nerium oleander L.) ethanolic flower extract in streptozotocin induced diabetic rats via biochemical, histological and molecular aspects
dc.typeArticle
dspace.entity.typePublication
local.api.response{"authors":[{"fullName":"Abdulhamit Battal","name":"Abdulhamit","surname":"Battal","rank":1,"pid":{"id":{"scheme":"orcid_pending","value":"0000-0001-6098-3908"},"provenance":null}},{"fullName":"Abdulahad Dogan","name":"Abdulahad","surname":"Dogan","rank":2,"pid":{"id":{"scheme":"orcid","value":"0000-0002-5438-8560"},"provenance":null}},{"fullName":"Ahmet Uyar","name":"Ahmet","surname":"Uyar","rank":3,"pid":{"id":{"scheme":"orcid","value":"0000-0003-4345-6756"},"provenance":null}},{"fullName":"Abdulbaki Demir","name":"Abdulbaki","surname":"Demir","rank":4,"pid":{"id":{"scheme":"orcid","value":"0000-0002-6867-4410"},"provenance":null}},{"fullName":"Ömer Faruk Keleş","name":"Ömer Faruk","surname":"Keleş","rank":5,"pid":{"id":{"scheme":"orcid","value":"0000-0002-7869-5311"},"provenance":null}},{"fullName":"Ismail Celik","name":"Ismail","surname":"Celik","rank":6,"pid":{"id":{"scheme":"orcid","value":"0000-0003-2199-6348"},"provenance":null}},{"fullName":"Mehmet Cengiz Baloglu","name":"Mehmet Cengiz","surname":"Baloglu","rank":7,"pid":{"id":{"scheme":"orcid","value":"0000-0003-2976-7224"},"provenance":null}},{"fullName":"Ali Aslan","name":"Ali","surname":"Aslan","rank":8,"pid":{"id":{"scheme":"orcid","value":"0000-0002-5122-6646"},"provenance":null}}],"openAccessColor":null,"publiclyFunded":false,"type":"publication","language":{"code":"eng","label":"English"},"countries":null,"subjects":[{"subject":{"scheme":"keyword","value":"Glycated Hemoglobin"},"provenance":null},{"subject":{"scheme":"keyword","value":"Blood Glucose"},"provenance":null},{"subject":{"scheme":"keyword","value":"Plant Extracts"},"provenance":null},{"subject":{"scheme":"keyword","value":"Flowers"},"provenance":null},{"subject":{"scheme":"keyword","value":"Lipids"},"provenance":null},{"subject":{"scheme":"keyword","value":"Antioxidants"},"provenance":null},{"subject":{"scheme":"keyword","value":"Streptozocin"},"provenance":null},{"subject":{"scheme":"SDG","value":"3. Good health"},"provenance":null},{"subject":{"scheme":"keyword","value":"Rats"},"provenance":null},{"subject":{"scheme":"keyword","value":"Diabetes Mellitus, Experimental"},"provenance":null},{"subject":{"scheme":"keyword","value":"Liver"},"provenance":null},{"subject":{"scheme":"keyword","value":"Animals"},"provenance":null},{"subject":{"scheme":"keyword","value":"Hypoglycemic Agents"},"provenance":null},{"subject":{"scheme":"keyword","value":"Insulin"},"provenance":null},{"subject":{"scheme":"keyword","value":"Nerium"},"provenance":null}],"mainTitle":"Exploring of the ameliorative effects of Nerium (Nerium oleander L.) ethanolic flower extract in streptozotocin induced diabetic rats via biochemical, histological and molecular aspects","subTitle":null,"descriptions":["Nerium oleander L. is ethnopharmacologically used for diabetes. Our aim was to investigate the ameliorative effects of ethanolic Nerium flower extract (NFE) in STZ-induced diabetic rats.Seven random groups including control group, NFE group (50 mg/kg), diabetic group, glibenclamide group and NFE treated groups (25 mg/kg, 75 mg/kg, and 225 mg/kg) were composed of forty-nine rats. Blood glucose level, glycated hemoglobin (HbA1c), insulin level, liver damage parameters and lipid profile parameters were investigated. Antioxidant defense system enzyme activities and reduced glutathione (GSH) and malondialdehyde (MDA) contents and immunotoxic and neurotoxic parameters were determined in liver tissue. Additionally, the ameliorative effects of NFE were histopathologically examined in liver. mRNA levels of SLC2A2 gene encoding glucose transporter 2 protein were measured by quantitative real time PCR.NFE caused decrease in glucose level and HbA1c and increase in insulin and C-peptide levels. Additionally, NFE improved liver damage biomarkers and lipid profile parameters in serum. Moreover, lipid peroxidation was prevented and antioxidant enzyme activities in liver were regulated by NFE treatment. Furthermore, anti-immunotoxic and anti-neurotoxic effects of NFE were determined in liver tissue of diabetic rats. Histopathogically, significant liver damages were observed in the diabetic rats. Histopathological changes were decreased partially in the 225 mg/kg NFE treated group. SLC2A2 gene expression in liver of diabetic rats significantly reduced compared to healthy rats and NFE treatment (25 mg/kg) caused increase in gene expression.Flower extract of Nerium plant may have an antidiabetic potential due to its high phytochemical content."],"publicationDate":"2023-03-10","publisher":"Springer Science and Business Media LLC","embargoEndDate":null,"sources":["Crossref"],"formats":null,"contributors":null,"coverages":null,"bestAccessRight":{"code":"c_14cb","label":"CLOSED","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/"},"container":{"name":"Molecular Biology Reports","issnPrinted":"0301-4851","issnOnline":"1573-4978","issnLinking":null,"ep":"4205","iss":null,"sp":"4193","vol":"50","edition":null,"conferencePlace":null,"conferenceDate":null},"documentationUrls":null,"codeRepositoryUrl":null,"programmingLanguage":null,"contactPeople":null,"contactGroups":null,"tools":null,"size":null,"version":null,"geoLocations":null,"id":"doi_dedup___::eb8b068ecc90129412c00a5657895500","originalIds":["8332","10.1007/s11033-023-08332-5","50|doiboost____|eb8b068ecc90129412c00a5657895500","36897524","50|od_____10157::b5de5b485d7476b66a6beb00437a846e","2054e126-ca81-49d5-a50c-d69e7f72dc20"],"pids":[{"scheme":"doi","value":"10.1007/s11033-023-08332-5"},{"scheme":"pmid","value":"36897524"}],"dateOfCollection":null,"lastUpdateTimeStamp":null,"indicators":{"citationImpact":{"citationCount":2,"influence":2.5629148e-9,"popularity":3.6743715e-9,"impulse":2,"citationClass":"C5","influenceClass":"C5","impulseClass":"C5","popularityClass":"C5"}},"instances":[{"pids":[{"scheme":"doi","value":"10.1007/s11033-023-08332-5"}],"license":"Springer Nature TDM","type":"Article","urls":["https://doi.org/10.1007/s11033-023-08332-5"],"publicationDate":"2023-03-10","refereed":"peerReviewed"},{"pids":[{"scheme":"pmid","value":"36897524"}],"alternateIdentifiers":[{"scheme":"doi","value":"10.1007/s11033-023-08332-5"}],"type":"Article","urls":["https://pubmed.ncbi.nlm.nih.gov/36897524"],"publicationDate":"2023-05-01","refereed":"nonPeerReviewed"},{"alternateIdentifiers":[{"scheme":"doi","value":"10.1007/s11033-023-08332-5"}],"type":"Article","urls":["https://avesis.yyu.edu.tr/publication/details/2054e126-ca81-49d5-a50c-d69e7f72dc20/oai"],"publicationDate":"2023-05-01","refereed":"nonPeerReviewed"}],"isGreen":false,"isInDiamondJournal":false}
local.import.sourceOpenAire
local.indexed.atWOS
local.indexed.atScopus
local.indexed.atPubMed

Dosyalar

Koleksiyonlar

Publications