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Apoptosis is induced by sub-acute exposure to 3-MCPD and glycidol on Wistar Albino rat brain cells

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dc.contributor.authorSevim, Çiğdem
dc.contributor.authorÖzkaraca, Mustafa
dc.contributor.authorKara, Mehtap
dc.contributor.authorUlaş, Nergis
dc.contributor.authorMendil, Ali Sefa
dc.contributor.authorMargina, Denisa
dc.contributor.authorTsatsakis, Aristidis
dc.date.accessioned2026-01-04T15:50:16Z
dc.date.issued2021-10-01
dc.description.abstract3-chloropropane-1,2-diol (3-MCPD) and its toxic metabolite glycidol were classified by the International Agency for Research on Cancer (IARC) as belonging to group 2B and 2A for humans. This study aimed to determine the sub-acute toxicity of these agents. Rats were exposed to 3-MCPD at 0.87 and 10 mg/kg/bw and glycidol (2,4 and 37,5 mg/kg/bw) for 90 days. miR-21 gene expression levels significantly decreased in all group's cerebellar tissues compared with control. Exposure to 10 mg/kg/bw 3-MCPD showed significant increases in PTEN in brain as compared to control group. The Akt gen expressions were significantly decreased in 3-MCPD and glycidol groups when compared to control group brains. Additionally, Caspase 3 and AIF immunopositivity significantly increased in 3-MCPD high dose and glycidol high dose groups in cerebellum granular layers compared to control. The results of the present study conclude that 3-MCPD and glycidol can induce apoptosis in rat brain tissue.
dc.description.urihttps://doi.org/10.1016/j.etap.2021.103735
dc.description.urihttps://pubmed.ncbi.nlm.nih.gov/34461274
dc.description.urihttps://dx.doi.org/10.1016/j.etap.2021.103735
dc.description.urihttps://avesis.atauni.edu.tr/publication/details/209d8594-1a52-4e80-9f72-f13cd857f701/oai
dc.identifier.doi10.1016/j.etap.2021.103735
dc.identifier.issn1382-6689
dc.identifier.openairedoi_dedup___::d9751c28cad952820924aca677346251
dc.identifier.orcid0000-0002-0575-3090
dc.identifier.orcid0000-0001-7764-5593
dc.identifier.orcid0000-0003-2340-6882
dc.identifier.orcid0000-0003-3289-147x
dc.identifier.orcid0000-0003-3824-2462
dc.identifier.pubmed34461274
dc.identifier.scopus2-s2.0-85113855354
dc.identifier.startpage103735
dc.identifier.urihttps://hdl.handle.net/20.500.12597/39093
dc.identifier.volume87
dc.identifier.wos000696705300003
dc.language.isoeng
dc.publisherElsevier BV
dc.relation.ispartofEnvironmental Toxicology and Pharmacology
dc.rightsCLOSED
dc.subjectMale
dc.subjectCaspase 3
dc.subjectPropanols
dc.subjectPTEN Phosphohydrolase
dc.subjectApoptosis Inducing Factor
dc.subjectBrain
dc.subjectalpha-Chlorohydrin
dc.subjectApoptosis
dc.subjectChemosterilants
dc.subjectRats
dc.subjectMicroRNAs
dc.subjectAnimals
dc.subjectEpoxy Compounds
dc.subjectRats, Wistar
dc.subjectProto-Oncogene Proteins c-akt
dc.subject.sdg3. Good health
dc.titleApoptosis is induced by sub-acute exposure to 3-MCPD and glycidol on Wistar Albino rat brain cells
dc.typeArticle
dspace.entity.typePublication
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