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Osajin from Maclura pomifera alleviates sepsis-induced liver injury in rats: biochemical, histopathological and immunohistochemical estimation

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dc.contributor.authorAlhilal, Mohammad
dc.contributor.authorErol, Huseyin Serkan
dc.contributor.authorYildirim, Serkan
dc.contributor.authorCakir, Ahmet
dc.contributor.authorKoc, Murat
dc.contributor.authorCelebi, Demet
dc.contributor.authorHalici, Mesut Bunyami
dc.date.accessioned2026-01-04T18:38:31Z
dc.date.issued2023-04-22
dc.description.abstractThis paper aimed to examine the impact of flavonoid osajin (OSJ) on liver damage induced by sepsis. A total of 30 male rats were divided into 5 groups (Sham, sepsis, OSJ 150, OSJ 300 and reference). During sepsis, elevated lipid peroxidation (LPO) level and catalase activity (CAT) and decreased glutathione (GSH) level and superoxide dismutase (SOD) activity were observed in hepatic tissues of sepsis group in comparison with Sham group. A strong interleukin-33 and caspase-3 expressions were detected in hepatic tissues of sepsis group. On the contrary, OSJ administration to OSJ 300 group showed a significant decrease (P < 0.001) in LPO level (176±2.926) and significant increase (P < 0.001) in GSH level (10.586±0.083) and SOD activity (29.152±0.094) in comparison with sepsis group (185.777±1.735, 8.246±0.124, 24.307±0.379 respectively). In addition, the consumption of OSJ reduced expressions of interleukin-33 and caspase-3 and improved histopathological integrity. In conclusions, OSJ has hepatoprotective effect against sepsis-induced liver injury.
dc.description.urihttps://doi.org/10.1080/16583655.2023.2201250
dc.description.urihttps://doaj.org/article/f6ed80b67f304cfe89eb3ae4d424470a
dc.description.urihttps://avesis.aybu.edu.tr/publication/details/7d03289b-68c0-428e-aa9c-0d30bf23a53e/oai
dc.description.urihttps://hdl.handle.net/20.500.12514/3563
dc.description.urihttps://avesis.atauni.edu.tr/publication/details/7d03289b-68c0-428e-aa9c-0d30bf23a53e/oai
dc.identifier.doi10.1080/16583655.2023.2201250
dc.identifier.eissn1658-3655
dc.identifier.openairedoi_dedup___::05723083974ffba8db73758871d7ba9c
dc.identifier.orcid0000-0002-2832-8409
dc.identifier.orcid0000-0002-9121-536x
dc.identifier.orcid0000-0002-7473-2955
dc.identifier.scopus2-s2.0-85153231436
dc.identifier.urihttps://hdl.handle.net/20.500.12597/40668
dc.identifier.volume17
dc.identifier.wos000974619100001
dc.language.isoeng
dc.publisherInforma UK Limited
dc.relation.ispartofJournal of Taibah University for Science
dc.rightsOPEN
dc.subjectsepsis
dc.subjectQ1-390
dc.subjectScience (General)
dc.subjectLiver
dc.subjectLiver
dc.subjectosajin
dc.subjectoxidative stress
dc.subjectsepsis
dc.subjectosajin
dc.subjectoxidative stress
dc.subject.sdg3. Good health
dc.titleOsajin from Maclura pomifera alleviates sepsis-induced liver injury in rats: biochemical, histopathological and immunohistochemical estimation
dc.typeArticle
dspace.entity.typePublication
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