Yayın:
Lanostane-Type Triterpenes and Abietane-Type Diterpene from the Sclerotia of Chaga Medicinal Mushroom, Inonotus obliquus (Agaricomycetes), and Their Biological Activities

Basit Görünüm
dc.contributor.authorAlzand, Kutaiba Ibrahin
dc.contributor.authorÜnal, Sabri
dc.contributor.authorBoufaris, Mansor S Mostafa
dc.date.accessioned2026-01-03T10:25:18Z
dc.date.issued2018-01-01
dc.description.abstractThree new lanostane-type triterpenes (compounds 1-3), 1 new abietane-type diterpene (compound 4), and 10 known compounds (5-14) were isolated from sclerotia of Inonotus obliquus. Their structures were elucidated through a combination of spectrometric techniques, including infrared, 1-dimensional, and 2-dimensional nuclear magnetic resonance and high-resolution electrospray mass spectrometry. In in vitro assays, compounds 2 and 4-12 showed hepatoprotective effects against D-galactosamine-induced damage in WB-F344 cells, with inhibitory effects from 35.4% to 83.8%. Compounds 3, 13, and 14 exhibited selective cytotoxicity against Bel-7402, A-549, or KB cell lines. Compounds 13 and 14 showed inhibitory effects against protein tyrosine kinases, with half-maximal inhibitory concentrations of 23.8 and 7.4 μmol/L, respectively.
dc.description.urihttps://doi.org/10.1615/intjmedmushrooms.2018026007
dc.description.urihttps://pubmed.ncbi.nlm.nih.gov/29953348
dc.description.urihttps://dx.doi.org/10.1615/intjmedmushrooms.2018026007
dc.identifier.doi10.1615/intjmedmushrooms.2018026007
dc.identifier.endpage516
dc.identifier.issn1521-9437
dc.identifier.openairedoi_dedup___::d842d57a2dd7bf4c3a3670d31d2df136
dc.identifier.pubmed29953348
dc.identifier.scopus2-s2.0-85049184268
dc.identifier.startpage507
dc.identifier.urihttps://hdl.handle.net/20.500.12597/36705
dc.identifier.volume20
dc.identifier.wos000436346300001
dc.language.isoeng
dc.publisherBegell House
dc.relation.ispartofInternational Journal of Medicinal Mushrooms
dc.subjectMagnetic Resonance Spectroscopy
dc.subjectMolecular Structure
dc.subjectBasidiomycota
dc.subjectEpithelial Cells
dc.subjectProtein-Tyrosine Kinases
dc.subjectTriterpenes
dc.subjectRats
dc.subjectLiver
dc.subjectA549 Cells
dc.subjectCell Line, Tumor
dc.subjectAbietanes
dc.subjectAnimals
dc.subjectHumans
dc.subject.sdg3. Good health
dc.titleLanostane-Type Triterpenes and Abietane-Type Diterpene from the Sclerotia of Chaga Medicinal Mushroom, Inonotus obliquus (Agaricomycetes), and Their Biological Activities
dc.typeArticle
dspace.entity.typePublication
local.api.response{"authors":[{"fullName":"Kutaiba Ibrahin, Alzand","name":"Kutaiba Ibrahin","surname":"Alzand","rank":1,"pid":null},{"fullName":"Sabri, Ünal","name":"Sabri","surname":"Ünal","rank":2,"pid":null},{"fullName":"Mansor S Mostafa, Boufaris","name":"Mansor S Mostafa","surname":"Boufaris","rank":3,"pid":null}],"openAccessColor":null,"publiclyFunded":false,"type":"publication","language":{"code":"eng","label":"English"},"countries":null,"subjects":[{"subject":{"scheme":"FOS","value":"0106 biological sciences"},"provenance":null},{"subject":{"scheme":"keyword","value":"Magnetic Resonance Spectroscopy"},"provenance":null},{"subject":{"scheme":"keyword","value":"Molecular Structure"},"provenance":null},{"subject":{"scheme":"keyword","value":"Basidiomycota"},"provenance":null},{"subject":{"scheme":"keyword","value":"Epithelial Cells"},"provenance":null},{"subject":{"scheme":"keyword","value":"Protein-Tyrosine Kinases"},"provenance":null},{"subject":{"scheme":"FOS","value":"01 natural sciences"},"provenance":null},{"subject":{"scheme":"keyword","value":"Triterpenes"},"provenance":null},{"subject":{"scheme":"keyword","value":"Rats"},"provenance":null},{"subject":{"scheme":"SDG","value":"3. Good health"},"provenance":null},{"subject":{"scheme":"keyword","value":"Liver"},"provenance":null},{"subject":{"scheme":"keyword","value":"A549 Cells"},"provenance":null},{"subject":{"scheme":"keyword","value":"Cell Line, Tumor"},"provenance":null},{"subject":{"scheme":"keyword","value":"Abietanes"},"provenance":null},{"subject":{"scheme":"keyword","value":"Animals"},"provenance":null},{"subject":{"scheme":"keyword","value":"Humans"},"provenance":null}],"mainTitle":"Lanostane-Type Triterpenes and Abietane-Type Diterpene from the Sclerotia of Chaga Medicinal Mushroom, Inonotus obliquus (Agaricomycetes), and Their Biological Activities","subTitle":null,"descriptions":["Three new lanostane-type triterpenes (compounds 1-3), 1 new abietane-type diterpene (compound 4), and 10 known compounds (5-14) were isolated from sclerotia of Inonotus obliquus. Their structures were elucidated through a combination of spectrometric techniques, including infrared, 1-dimensional, and 2-dimensional nuclear magnetic resonance and high-resolution electrospray mass spectrometry. In in vitro assays, compounds 2 and 4-12 showed hepatoprotective effects against D-galactosamine-induced damage in WB-F344 cells, with inhibitory effects from 35.4% to 83.8%. Compounds 3, 13, and 14 exhibited selective cytotoxicity against Bel-7402, A-549, or KB cell lines. Compounds 13 and 14 showed inhibitory effects against protein tyrosine kinases, with half-maximal inhibitory concentrations of 23.8 and 7.4 μmol/L, respectively."],"publicationDate":"2018-01-01","publisher":"Begell House","embargoEndDate":null,"sources":["Crossref"],"formats":null,"contributors":null,"coverages":null,"bestAccessRight":null,"container":{"name":"International Journal of Medicinal Mushrooms","issnPrinted":"1521-9437","issnOnline":null,"issnLinking":null,"ep":"516","iss":null,"sp":"507","vol":"20","edition":null,"conferencePlace":null,"conferenceDate":null},"documentationUrls":null,"codeRepositoryUrl":null,"programmingLanguage":null,"contactPeople":null,"contactGroups":null,"tools":null,"size":null,"version":null,"geoLocations":null,"id":"doi_dedup___::d842d57a2dd7bf4c3a3670d31d2df136","originalIds":["10.1615/intjmedmushrooms.2018026007","50|doiboost____|d842d57a2dd7bf4c3a3670d31d2df136","29953348","2804001334"],"pids":[{"scheme":"doi","value":"10.1615/intjmedmushrooms.2018026007"},{"scheme":"pmid","value":"29953348"}],"dateOfCollection":null,"lastUpdateTimeStamp":null,"indicators":{"citationImpact":{"citationCount":3,"influence":2.6688018e-9,"popularity":2.752351e-9,"impulse":2,"citationClass":"C5","influenceClass":"C5","impulseClass":"C5","popularityClass":"C5"}},"instances":[{"pids":[{"scheme":"doi","value":"10.1615/intjmedmushrooms.2018026007"}],"type":"Article","urls":["https://doi.org/10.1615/intjmedmushrooms.2018026007"],"publicationDate":"2018-01-01","refereed":"peerReviewed"},{"pids":[{"scheme":"pmid","value":"29953348"}],"alternateIdentifiers":[{"scheme":"doi","value":"10.1615/intjmedmushrooms.2018026007"}],"type":"Article","urls":["https://pubmed.ncbi.nlm.nih.gov/29953348"],"publicationDate":"2018-10-16","refereed":"nonPeerReviewed"},{"alternateIdentifiers":[{"scheme":"mag_id","value":"2804001334"},{"scheme":"doi","value":"10.1615/intjmedmushrooms.2018026007"}],"type":"Article","urls":["https://dx.doi.org/10.1615/intjmedmushrooms.2018026007"],"refereed":"nonPeerReviewed"}],"isGreen":false,"isInDiamondJournal":false}
local.import.sourceOpenAire
local.indexed.atWOS
local.indexed.atScopus
local.indexed.atPubMed

Dosyalar

Koleksiyonlar

Publications