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Exploring Sorbus torminalis Leaves: Unveiling a Promising Natural Resource for Diverse Chemical and Biological Applications

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dc.contributor.authorGunes, Ak
dc.contributor.authorEnis Fuat, Tüfekci
dc.contributor.authorAhmed M, Mustafa
dc.contributor.authorGiovanni, Caprioli
dc.contributor.authorYasemin Celik, Altunoglu
dc.contributor.authorMehmet Cengiz, Baloglu
dc.contributor.authorUgur, Cakılcıoglu
dc.contributor.authorRıdvan, Polat
dc.contributor.authorEkrem, Darendelioglu
dc.contributor.authorGokhan, Zengin
dc.date.accessioned2026-01-06T06:01:28Z
dc.date.issued2024-02-01
dc.description.abstractAbstractSorbus torminalis (L.) Crantz has a rich history of versatile applications spanning the fields of medicine and nutrition. It is noteworthy that the decoction obtained from S. torminalis leaves is a traditional treatment method against both diabetes and stomach disorders. Phytochemical profiling determined by HPLC/MS‐MS. The effects of the extracts on cell viability were investigated using the MTT (3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl tetrazolium bromide) method against MDA‐MB‐231 cell line (human breast adenocarcinoma).The ethanol/water extract contained more concentration of total phenolic (91.41 mg gallic acid (GAE) equivalent /gr) and flavanoid (29.10 mg rutin (RE) equivalent/gr) in the tested extract (p<0.05). Resulting of HPLC analysis, the chemical constituents varied depending on the solvents and chlorogenic acid, hyperoside, isoquercetin, delphindin‐3,5‐diglucoside, procyanidin B2, epicatechin, neochlorogenic acid, 3,5‐dicaffeoylquinic acid were identified in all extracts. Overall, ethanol, n‐hexane and ethyl acetate extracts showed the highest inhibition for the tyrosinase enzyme. The effect of leaf extracts of S. torminalis on antimicrobial, biofilm inhibitory, and anticancer activities was examined. Based on outcomes of our study recognize this plant as a critical source of medically active chemicals for feasible phytopharmaceutical and nutraceutical applications, providing the first scientific insight into the detailed biological and chemical profiles of S. torminalis.
dc.description.urihttps://doi.org/10.1002/cbdv.202301596
dc.description.urihttps://pubmed.ncbi.nlm.nih.gov/38126959
dc.description.urihttps://onlinelibrary.wiley.com/doi/10.1002/cbdv.202301596
dc.description.urihttps://hdl.handle.net/11581/479243
dc.description.urihttps://doi.org/https://doi.org/10.1002/cbdv.202301596
dc.identifier.doi10.1002/cbdv.202301596
dc.identifier.eissn1612-1880
dc.identifier.issn1612-1872
dc.identifier.openairedoi_dedup___::d0b209d49a702853b4d8ca2b60382505
dc.identifier.orcid0000-0001-5051-2694
dc.identifier.orcid0000-0002-5530-877x
dc.identifier.orcid0000-0001-6548-7823
dc.identifier.pubmed38126959
dc.identifier.scopus2-s2.0-85184193441
dc.identifier.urihttps://hdl.handle.net/20.500.12597/43855
dc.identifier.volume21
dc.identifier.wos001158274100001
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofChemistry & Biodiversity
dc.rightsRESTRICTED
dc.subjectFlavonoids
dc.subjectPlant Leaves
dc.subjectEthanol
dc.subjectPlant Extracts
dc.subjectPhytochemicals
dc.subjectHumans
dc.subjectSorbus
dc.subjectAntioxidants
dc.subject.sdg2. Zero hunger
dc.subject.sdg6. Clean water
dc.subject.sdg3. Good health
dc.titleExploring Sorbus torminalis Leaves: Unveiling a Promising Natural Resource for Diverse Chemical and Biological Applications
dc.typeArticle
dspace.entity.typePublication
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It is noteworthy that the decoction obtained from <jats:italic>S. torminalis</jats:italic> leaves is a traditional treatment method against both diabetes and stomach disorders. Phytochemical profiling determined by HPLC/MS‐MS. The effects of the extracts on cell viability were investigated using the MTT (3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl tetrazolium bromide) method against MDA‐MB‐231 cell line (human breast adenocarcinoma).The ethanol/water extract contained more concentration of total phenolic (91.41 mg gallic acid (GAE) equivalent /gr) and flavanoid (29.10 mg rutin (RE) equivalent/gr) in the tested extract (p&lt;0.05). Resulting of HPLC analysis, the chemical constituents varied depending on the solvents and chlorogenic acid, hyperoside, isoquercetin, delphindin‐3,5‐diglucoside, procyanidin B2, epicatechin, neochlorogenic acid, 3,5‐dicaffeoylquinic acid were identified in all extracts. Overall, ethanol, n‐hexane and ethyl acetate extracts showed the highest inhibition for the tyrosinase enzyme. The effect of leaf extracts of <jats:italic>S. torminalis</jats:italic> on antimicrobial, biofilm inhibitory, and anticancer activities was examined. 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